TIS21 /BTG2 inhibits breast cancer growth and progression by differential regulation of mTORc1 and mTORc2 –AKT1–NFAT1–PHLPP2 signaling axis

ConclusionsTIS21/BTG2 significantly lost in the infiltrating ductal carcinoma, but it can inhibit cancer growth via the TIS21/BTG2–tsc1/2 –mTORc1–p70S6K axis and downregulate cancer progression via the TIS21/BTG2–mTORc2–AKT1–NFAT1–PHLPP2 pathway.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research