Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged endothelial activation [Gene Regulation]
In conclusion, lysophospholipids such as LPC and LPI induce innate immune cell transdifferentiation in HAECs. The concept of prolonged endothelial activation, discovered here, is relevant for designing new strategies for managing cardiovascular diseases.
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Xinyuan Li, Luqiao Wang, Pu Fang, Yu Sun, Xiaohua Jiang, Hong Wang, Xiao-Feng Yang Tags: RNA Source Type: research
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