Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies

In conclusion, while we found no evidence for mCALR derived neoepitope presentation in the context of the HLA class I alleles studied, our data suggests that the recurrent pR465H mutation in FBXW7 may encode an HLA-A*11:01 presented neoepitope, and warrants further investigation as a target for T cell based immunotherapy of cancer.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research