Fentanyl-related deaths double in six months; US government takes some action

A new report by the US Centers for Disease Control and Prevention found that the number of overdose deaths involving the potent narcotic fentanyl and variations of the drug nearly doubled between the last half of 2016 and the first half of 2017.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 24 May 2019Source: Life SciencesAuthor(s): Feng-Ling Yu, Jun-Wen Wu, He ZhuAbstractAimAcetaminophen (APAP) overdose is the most frequent cause of drug-induced liver damage. Magnolia officinalis is a traditional hepatoprotective Chinese medicine and Honokiol (HO) is the major active constituent. The present study was to investigate the effect of HO on APAP-induced hepatotoxicity and related mechanisms.Main methodsFour groups of mice were subjected to treatment as vehicle, APAP, APAP + HO and APAP + HO + NRF2 inhibitor. The morphological and biochemical assessments were used to ...
Source: Life Sciences - Category: Biology Source Type: research
Gail Box vividly remembers the day in May 2011 when she first learned her 22-year-old son Austin, a University of Oklahoma linebacker, was abusing opioid painkillers: It was the day he died of an overdose.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
In this report, we characterize the case of a 23-year-old male regular drug user who died a few hours after NEH and ADB-FUBINACA consumption. His medical history showed arrhythmia in childhood, and some seizures. Autopsy found he had a BMI of 42.9, a hypertrophic and dilated heart, severe atherosclerosis of the valves, coronaries and the arteries, and edema of the internal organs. Histology confirmed those findings. Postmortem blood levels of NEH were 285 ng/ml, along with 0.08 ng/ml ADB-FUBINACA and five ADB-FUBINACA metabolites. Based on the blood concentrations measured in suspected drug users (≤83.9 ng/ml) we ...
Source: Journal of Forensic and Legal Medicine - Category: Forensic Medicine Source Type: research
IMPORTANCE: The rate of youth suicide has increased over the past 15 years in the United States as has the rate of death due to opioid overdose in adults of parental age. OBJECTIVE: To explore the possible connection between parental use of prescri...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Neuropsychopharmacology, Published online: 24 May 2019; doi:10.1038/s41386-019-0418-4Utility of fentanyl vaccines: unique challenges posed by preventing opioid overdose and treating opioid use disorder
Source: Neuropsychopharmacology - Category: Neurology Authors: Source Type: research
Between 2010 and 2016, veteran deaths from opioid overdoses spiked 65 percent.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
THURSDAY, May 23, 2019 -- Patients at high risk of opioid overdose rarely receive prescriptions for naloxone, despite many interactions with the health care system, according to a study published online May 3 in JAMA Network Open. Sarah Follman,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Authors: Paice JA Abstract Advances in cancer treatment have led to a growing number of survivors. At least 40% of those survivors live with chronic pain and need pain control medication. This coincides with an epidemic of opioid misuse and overdose deaths, resulting in restrictive practices that can impact patients who experience severe pain. Oncologists and other healthcare professionals who treat patients with cancer need to balance considerations of opioid misuse with effective pain control and become better educated about risk factors and management of opioids in cancer survivors. PMID: 31117028 [PubMed - in process]
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
We report the case of a 21-year-old male with a history of mental illness that presented with selective mutism, disorganized speech, thought process and behavior, and auditory hallucinations who accidentally received 624 mg Paliperidone Palmitate intramuscularly with no reported side effects after 2 weeks of monitoring and observation. Paliperidone is a D2, 5HT2A receptor antagonist with additional antagonist activity at α-1 and α-2, H-1 receptor sites, and four metabolic pathways identified for its metabolism. Studies have reported adverse effects such as acute dystonia, acute renal failure, and cardiov...
Source: Case Reports in Psychiatry - Category: Psychiatry Tags: Case Rep Psychiatry Source Type: research
This article will explain the reasons behind the low percentages of citizens being trained and utilized to address critical emergencies in their community, as well as detail a revised first-aid program that was developed based on these findings and current leading threats to modern society. The ACT (i.e., Antidote, CPR/AED, Tourniquet) program provides an evidence-based approach that effectively and efficiently empowers a greater portion of the public to save a life. In an effort to improve cardiac resuscitation results and address multiple other emergency response needs, South County Fire Deputy Chief Shaughn Maxwell, EMT...
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: Trauma Exclusive Articles Source Type: news
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