The impact of risk minimization measures on compliance and prescribing practices of flupirtine in Germany.

CONCLUSIONS: These findings demonstrate that while physicians restricted flupirtine prescriptions to short-term use in the target population of acute pain, not all labeling elements were followed to the same extent in routine practice. PMID: 29992843 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research

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CONCLUSIONS: Insomnia is prevalent and associated with substantial population-level burden in self-assessed health. The co-occurrence of insomnia with common medical conditions is differentially related to pain and to a lesser extent to stressful life events and mental disorders. PMID: 30256547 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Publication date: Available online 5 March 2018 Source:The Lancet Author(s): Stephen A Harrison, Mary E Rinella, Manal F Abdelmalek, James F Trotter, Angelo H Paredes, Hays L Arnold, Marcelo Kugelmas, Mustafa R Bashir, Mark J Jaros, Lei Ling, Stephen J Rossi, Alex M DePaoli, Rohit Loomba Background Non-alcoholic steatohepatitis is a chronic liver disease characterised by the presence of hepatic steatosis, inflammation, and hepatocellular injury, for which no Food and Drug Administration (FDA)-approved treatment exists. FGF19 is a hormone that regulates bile acid synthesis and glucose homoeostasis. We aimed to assess the s...
Source: The Lancet - Category: General Medicine Source Type: research
Follow me on Twitter @RobShmerling Ever wonder what other people are wondering about? I know I do. So, here are the top 10 health searches in Google for 2017. And just so you don’t have to look each one up, I’ve provided a brief answer. You’re welcome. 1.  What causes hiccups? I was surprised this one made it to the top 10 list of health searches. Maybe this search is common because hiccups are as mysterious as they are universal. I’ve written about hiccups before, but let’s just say the cause in any individual person is rarely known or knowable. Then again, the reason hiccups stop is als...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Source Type: blogs
32  year old male presented with abdominal pain of one week duration. He was diagnosed with alcohol related necrotizing pancreatitis 10 weeks ago. Computed tomography (CT) of abdomen revealed a large, walled off necrosis (WON) compressing the stomach. The WON was divided into two parts by a thin sept um (Fig. 1A; arrows), as demonstrated on endoscopic ultrasound (EUS) also (Fig. 1B; arrows). Under EUS guidance the WON was punctured using a 19 G needle and thereafter the needle was pushed further inwards, piercing the dividing septum of WON also.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research
Non-alcoholic fatty liver disease (NAFLD) is a major public health problem afflicting approximately one billion individuals worldwide. Liver biopsy is considered the gold standard for assessment of liver disease severity in patients with NAFLD. However, it is invasive, has high inter-observer variability, and is associated with adverse effects, including pain, infection and, albeit rarely, death. It is also impractical because of the large number of individuals who have NAFLD. Therefore, tools to non-invasively assess disease severity in NAFLD are urgently needed.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Review Source Type: research
ConclusionLeaks from subvesical bile ducts are rare complications in LT recipients, but should be recognized as a  source of intra-abdominal infection.
Source: European Surgery - Category: Surgery Source Type: research
In a new study of the leading causes of death in the U.S., researchers say that opioids have contributed to a shortening of life expectancy. Scientists from the Centers for Disease Control and Prevention report in JAMA that while life expectancy in the U.S. increased overall from 2000 to 2015, that improvement was blunted by deaths from opioid overdoses. (According to other recent research, deaths from opioid overdoses nearly doubled in the U.S. from 2009 to 2015.) The life expectancy for people born in 2015 increased by two years compared to people born in 2000, from 76 years to 78. Much of that gain was due to decreases ...
Source: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized are opioids painkillers drug addiction Drugs leading causes of death opioid addiction opioid epidemic opioid overdose opioid overdoses opioid pain killers what are opioids what is the leading cause of death Source Type: news
The objective of our study was to identify clinical differences between morbidly obese women and men seeking LRYGB. Data from 83,059 patients in the Surgical Review Corporation's Bariatric Outcomes Longitudinal Database who were about to undergo LRYGB was analyzed in two groups: women (n = 65,325) and men (n = 17,734). Statistics were evaluated with analysis of variance and the χ2 equation. Cardiopulmonary comorbidities affected more men than women (P ≤ 0.0002) except for female asthma (P
Source: The American Surgeon - Category: Surgery Authors: Tags: Am Surg Source Type: research
In this study, the effects of R. oldhamii leaf extract on inhibiting the free fatty acid (FFA)-induced accumulation of fat in HepG2 cells and on improving fatty liver syndrome in mice with high fat diet (HFD)-induced NAFLD were investigated. For the in vitro assay, HepG2 cells were treated with FFAs (oleate/palmitate = 2:1) with or without treatment with R. oldhamii leaf ethyl acetate (EtOAc) fraction to observe lipid accumulation using Nile red and oil red O stains. For the in vivo assay, C57BL/6 mice were randomly assigned to three groups (n = 5), including the normal diet group, the HFD group and the HFD+EtOAc group. Af...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
CONCLUSION Future studies comparing the effect of various bariatric procedures, including MGB, are necessary to help clinicians decide the optimal procedure for patients with this liver condition.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
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