The impact of risk minimization measures on compliance and prescribing practices of flupirtine in Germany.

CONCLUSIONS: These findings demonstrate that while physicians restricted flupirtine prescriptions to short-term use in the target population of acute pain, not all labeling elements were followed to the same extent in routine practice. PMID: 29992843 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research

Related Links:

Authors: Elmakki EE Abstract Hepatocellular carcinoma is the most frequent type of liver malignancy. Most cases of hepatocellular carcinoma are secondary to either viral hepatitis (hepatitis B, C) or alcoholic cirrhosis. Liver cirrhosis due to any other causes is considered as a risk factor for development of hepatocellular carcinoma; however, hepatocellular carcinoma in a young patient with no cirrhosis or fibrosis is a relatively rare condition. The present case report describes a young 24-years-old male patient who presented with a two-month history of fever, right upper quadrant abdominal pain, and weight loss ...
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
ConclusionPMVT after CRC surgery is likely an early postoperative event in most patients. The incidence of clinically significant PMVT in patients with CRC may be lower than previously reported. CT was reliable in the diagnosis and follow-up of these patients. Most patients with PMVT can be managed conservatively without serious long-term morbidity.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
A 52-year-old male with history of excessive alcohol use was evaluated for abdominal pain and hematochezia. Colonoscopy was only significant for a single diverticulum in the transverse colon and esophagogastroduodenoscopy was negative. Deep anterograde and spiral retrograde endoscopies also did not reveal any abnormality. Intra-operative enteroscopy showed few non-bleeding small angioectasias in the jejunum and ileum that were ligated. Despite these interventions, the patient presented again with hematochezia and epigastric pain.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research
Alcohol is embedded in our society, and it is difficult to be in a public space without seeing a reference to alcohol or being offered a drink. Alcohol is broken down in the liver by an enzyme called alcohol dehydrogenase. People with a variant in this enzyme have issues with metabolizing alcohol and can develop total body flushing or reddening of the skin. Alcohol consumption has been associated with pregnancy defects, liver disease, pancreatitis, high blood pressure, coronary artery disease, stroke, cancer, addiction issues, and physical injury (trauma to self/others with acute intoxication). The health benefits of alcoh...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alcohol Headache Health Source Type: blogs
​BY ARJUN BHARADWAJ; MARGARET GAVOR, MBChB, MPH; &KHALID MALIK, MDA 65-year-old man presented to the emergency department complaining of sudden-onset left-sided abdominal pain followed by a “seizure.” His abdominal pain started a few hours prior to presentation, was sharp in nature, and radiated to his back and umbilicus. The pain waxed and waned, worsened when he walked or sat up, and at its worst was a 10/10. He took a laxative and two antacids, but received no relief.Each “seizure” episode lasted about 30 seconds and occurred every five minutes. He said he felt drained after each event but ...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
CONCLUSIONS: Insomnia is prevalent and associated with substantial population-level burden in self-assessed health. The co-occurrence of insomnia with common medical conditions is differentially related to pain and to a lesser extent to stressful life events and mental disorders. PMID: 30256547 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Publication date: Available online 5 March 2018 Source:The Lancet Author(s): Stephen A Harrison, Mary E Rinella, Manal F Abdelmalek, James F Trotter, Angelo H Paredes, Hays L Arnold, Marcelo Kugelmas, Mustafa R Bashir, Mark J Jaros, Lei Ling, Stephen J Rossi, Alex M DePaoli, Rohit Loomba Background Non-alcoholic steatohepatitis is a chronic liver disease characterised by the presence of hepatic steatosis, inflammation, and hepatocellular injury, for which no Food and Drug Administration (FDA)-approved treatment exists. FGF19 is a hormone that regulates bile acid synthesis and glucose homoeostasis. We aimed to assess the s...
Source: The Lancet - Category: General Medicine Source Type: research
A 48-year-old woman with no past medical history presented to the primary care clinic with right-sided abdominal pain, fatigue, and a 20-lb weight loss over 3 months. She described a short period of heavy alcohol use (a bottle of wine per day for 3 years), although she had been abstinent for 1 year before presentation. She has 2 daughters with Alagille syndrome. She had no other risk factors for liver disease. Initial evaluation revealed abnormal liver biochemical tests (alanine aminotransferase: 130 U/L, aspartate aminotransferase: 107 U/L, alkaline phosphatase: 622 U/L, total bilirubin: 0.9 mg/dL).
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research
Follow me on Twitter @RobShmerling Ever wonder what other people are wondering about? I know I do. So, here are the top 10 health searches in Google for 2017. And just so you don’t have to look each one up, I’ve provided a brief answer. You’re welcome. 1.  What causes hiccups? I was surprised this one made it to the top 10 list of health searches. Maybe this search is common because hiccups are as mysterious as they are universal. I’ve written about hiccups before, but let’s just say the cause in any individual person is rarely known or knowable. Then again, the reason hiccups stop is als...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Source Type: blogs
32  year old male presented with abdominal pain of one week duration. He was diagnosed with alcohol related necrotizing pancreatitis 10 weeks ago. Computed tomography (CT) of abdomen revealed a large, walled off necrosis (WON) compressing the stomach. The WON was divided into two parts by a thin sept um (Fig. 1A; arrows), as demonstrated on endoscopic ultrasound (EUS) also (Fig. 1B; arrows). Under EUS guidance the WON was punctured using a 19 G needle and thereafter the needle was pushed further inwards, piercing the dividing septum of WON also.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research
More News: Alcoholism | Databases & Libraries | Germany Health | Liver | Liver Disease | Pain | Research | Study | Substance Abuse | Urology & Nephrology