Rheumatoid arthritis: goal should be remission or low disease activity, says NICE

Source: BMJ News - Category: General Medicine Source Type: research

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Conclusion: Rheumatology and internal medicine patients, including patients treated with methotrexate without corticosteroids, are at risk of developing chronic HEV infection. Rheumatology and internal medicine patients with abnormal liver tests should be screened for HEV infection.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Authors: Curtis JR, Brahe CH, Østergaard M, Hetland ML, Hambardzumyan K, Saevarsdottir S, Wang X, Flake DD, Sasso EH, Huizinga TW Abstract OBJECTIVE: To compare the multi-biomarker disease activity (MBDA) score with the DAS28-CRP and CRP for predicting risk of radiographic progression in patients with rheumatoid arthritis. METHODS: Published studies of the MBDA score and radiographic progression with ≥100 patients per cohort were evaluated. Rates of radiographic progression over 1 year were determined across the low/moderate/high categories for MBDA score (low/moderate/high: 44), DAS28-CRP (low/modera...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Publication date: Available online 20 February 2019Source: Pharmacological ResearchAuthor(s): Yueyang Zhang, Binhua Zou, Yanhui Tan, Jianbing Su, Yiyuan Wang, Jialan Xu, Lei Tao, Hua Zhou, Liang Liu, Xiaojuan LiAbstractSinomenine (SIN) is an anti-inflammatory and antiarthritic alkaloid derived from Sinomenium acutum, and the product Zhengqing Fengtongning produced from SIN has been marketed in China for treating rheumatoid arthritis (RA). Interestingly, we recently found that SIN could significantly ameliorate bone destruction induced by breast cancer cells in mice. Micro-CT examination showed that bone loss of the trabecu...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
In conclusion, the formulation of QCT- NE gel is an efficient topical treatment strategy for rheumatoid arthritis.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In a study, researchers found extracellular vesicles may contribute to the greater disease severity typically seen in patients with seropositive rheumatoid arthritis (RA). Specifically, in these patients, extracellular vesicles can activate mononuclear phagocytes and induce proinflammatory cytokines in vitro...
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Rheumatoid Arthritis Source Type: research
(MedPage Today) -- Risk for rheumatoid arthritis declined with many years'cessation, but some risk remained
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news
(Brigham and Women's Hospital) Analysis of data from the Nurses' Health Studies demonstrates for first time that behavior change can delay or even prevent the most severe form of rheumatoid arthritis.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Analysis demonstrates for first time that behavior change can delay or prevent most severe form of rheumatoid arthritis
Source: BWH News - Category: Hospital Management Source Type: news
ConclusionsPDP should be considered as a differential diagnosis when a patient presents with hypertrophic osteoarthropathy and acromegalic features.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
AbstractObjectivesEvaluate abatacept retention over 2  years in the AbataCepT In rOutiNe clinical practice (ACTION) study.MethodACTION was an international, observational study of patients with moderate-to-severe rheumatoid arthritis (RA) who initiated intravenous abatacept. Crude abatacept retention rates over 2  years were estimated using Kaplan–Meier analyses in biologic-naive and -failure patients. Clinically relevant risk factors and significant prognostic factors for retention were evaluated using a Cox proportional hazards multivariable model.ResultsOverall, 2350/2364 enrolled patients were evaluable...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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