Drug Combination Boosts Older Adults' Immunity in Early Trial Drug Combination Boosts Older Adults' Immunity in Early Trial

A phase 2a randomized, placebo-controlled clinical trial showed that a combination of drugs decreases the incidence of infections, including influenza and pneumonia, in older adults.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Family Medicine/Primary Care News Source Type: news

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A pilot protocol developed at Memorial Sloan Kettering Cancer Center resulted in exponential increases in both influenza and pneumococcal vaccinations in the outpatient setting.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
This study examined the relationship between resident race and immunization status in long-term care facilities (LTCFs). Race was captured at the resident and the facility racial composition level.DesignThirty-six long-term care facilities varying in racial composition and size were selected for site visits.SettingLTCFs were urban and rural, CMS certified, and non-hospital administered.MeasurementsChart abstraction was used to determine race, immunization, and refusal status for the 2010 –2011 flu season (influenza 1), the 2011–2012 flu season (influenza 2), and the pneumococcal pneumonia vaccine for all reside...
Source: Journal of Racial and Ethnic Health Disparities - Category: International Medicine & Public Health Source Type: research
Abstract We used deep sequencing of the 16S rRNA gene from sputum to identify Haemophilus influenza in a patient with community-acquired pneumonia. This method may be more effective than conventional diagnostic tests in pneumonia patients because of its speed and sensitivity. PMID: 29989532 [PubMed - as supplied by publisher]
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Tags: Emerg Infect Dis Source Type: research
We report a case of a 13-year-old female who presented to the Emergency Department with altered mental status and respiratory distress following a treatment course for influenza. She was diagnosed with multifocal pneumonia and developed fulminant respiratory failure requiring ECLS. The causative organism was later found to be Methicillin-Resistant Staphylococcus Aureus (MRSA). She was maintained on ECLS for 49 days and developed secondary complications of lung necrosis, an intrathoracic hematoma, and multiple bronchopleural fistulae. She was managed non-operatively for these complications until she stabilized enough to be ...
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
We present a case of refractory acute hypoxemic respiratory failure due to influenza B pneumonia with concomitant large intra-atrial shunt (IAS) and severe pulmonary regurgitation in a patient with Saethre-Chotzen syndrome with prior pulmonary homograft placement. Our patient's hypoxemia improved with inhaled nitric oxide as an adjunct to mechanical ventilation without requiring extracorporeal membrane oxygenation, and eventually a percutaneous closure with a 30 mm CardioSeal patent foramen ovale closure device was accomplished. However, his peri-procedural hospital course was complicated by occluder device migration, whic...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
We report a case of acute disseminated encephalomyelitis (ADEM) secondary to Mycoplasma pneumoniae infection that failed to improve with methylprednisolone and intravenous immunoglobulin (IVIG); who responded with plasmapheresis. A 21- year- old female with an unremarkable medical history, initially presented to an outside hospital with fever and an influenza-like illness and was subsequently intubated for worsening sensorium. Brain magnetic resonance imaging was suggestive of ADEM or vasculitis for which she received five days of pulse steroids and IVIG. She showed no signs of improvement and was transferred to our hospit...
Source: IDCases - Category: Infectious Diseases Source Type: research
ConclusionEarly detection and referral, and early antiviral treatment with a strict control of nosocomial spread is essential in patients with cirrhosis during epidemic influenza.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
Publication date: May 2018Source: Journal of Pharmacological Sciences, Volume 137, Issue 1Author(s): Hui Li, Xin Chen, Shu-Jun ZhouAbstractDauricine, isolated from Menispermum dauricum, has been widely used for treatment of various diseases, including cardiac ischemia and inflammation-related diseases. However, little is known regarding to the effect of dauricine on severe pneumonia. Therefore, the aim was to investigate the effect of dauricine on severe pneumonia and its mechanism during progress. Herein, H5N1 and Streptococcus pneumoniae (D39) were conducted to induce severe pneumonia in both BEAS-2B cells and mice. In&n...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
The objective of this study was to test the relevance of such a model for the discovery and validation of antiviral drugs. Fully differentiated 3D nasal epithelium cultures were inoculated with picornaviruses, a coronavirus and influenza A viruses in the absence or in the presence of reference antiviral drugs. Results showed that, rupintrivir efficiently inhibits the replication of respiratory picornaviruses in a dose dependent manner and prevents the impairment of the mucociliary clearance. Similarly, oseltamivir reduced the replication of influenza A viruses in a dose dependent manner and prevented the impairment of the ...
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 8 June 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): I-Chia Su, Kai-Ling Lee, Hsin-Yi Liu, Han-Chuan Chuang, Li-Yuan Chen, Yuarn-Jang LeeAbstractCoinfection with Pseudomonas aeruginosa in patients with influenza is rare. Herein, we report a 39-year-old female patient who presented with severe community-acquired pneumonia due to coinfection with influenza A(H1N1)pdm09 and P. aeruginosa, which progressed to multifocal pneumonia with a fatal outcome.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
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