Drug Combination Boosts Older Adults' Immunity in Early Trial Drug Combination Boosts Older Adults' Immunity in Early Trial

A phase 2a randomized, placebo-controlled clinical trial showed that a combination of drugs decreases the incidence of infections, including influenza and pneumonia, in older adults.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Family Medicine/Primary Care News Source Type: news

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AbstractPurposeTo compare the frequency and the severity of influenza and respiratory syncytial viruses (RSV) infections among children
Source: Infection - Category: Infectious Diseases Source Type: research
Authors: Kaufman MB Abstract Arikayce (amikacin liposome inhalation suspension) for Mycobacterium avium complex lung disease; Xofluza (baloxavir marboxil) for acute uncomplicated influenza; and Nuzyra (omadacycline) for community-acquired bacterial pneumonia and/or acute bacterial skin and skin structure infections. PMID: 30766008 [PubMed]
Source: P and T - Category: Drugs & Pharmacology Tags: P T Source Type: research
Abstract CDC collects, compiles, and analyzes data on influenza activity and viruses in the United States. During September 30, 2018-February 2, 2019,* influenza activity† in the United States was low during October and November, increased in late December, and remained elevated through early February. As of February 2, 2019, this has been a low-severity influenza season (1), with a lower percentage of outpatient visits for influenza-like illness (ILI), lower rates of hospitalization, and fewer deaths attributed to pneumonia and influenza, compared with recent seasons. Influenza-associated hospitalization r...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
The 2018-2019 flu season has been a relatively mild one — and a pretty effective flu shot is part of the reason why. Mid-season estimates suggest that the flu shot has reduced the risk of illness by around 47% in vaccinated people, according to a report from the Centers for Disease Control and Prevention (CDC) released Thursday. During the severe 2017-2018 flu season, vaccine efficacy was estimated at just 36%. The difference is partly because the dominant influenza virus last year, H3N2, is known to cause more serious illnesses and to be less responsive to vaccination than other strains. This year, H1N1 — whic...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime public health Source Type: news
Conclusion.Integrating pharmacists into the care of older adults with cancer is feasible with encouraging preliminary efficacy for enhancing medication management and improving vaccination rates.Implications for Practice.Results of this study showed the feasibility, acceptability, and preliminary efficacy of an intervention integrating pharmacists into the care of older adults with cancer. Notably, patients assigned to the intervention had fewer discrepant medications and were more likely to acquire vaccinations for pneumonia and influenza. Importantly, this work represents the first randomized controlled trial involving t...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Symptom Management and Supportive Care, Health Outcomes and Economics of Cancer Care, Geriatric Oncology Source Type: research
Abstract BACKGROUND: Observational studies of the relative effectiveness of influenza vaccines are essential for public health decision making. Their estimates, however, are subject to bias due to unmeasured confounders. Instrumental variable (IV) methods can control for observed and unobserved confounders. METHODS: We used linked electronic medical record databases in the Veterans Health Administration (VHA) as well as Medicare administrative files to examine the relative vaccine effectiveness (rVE) of high-dose influenza vaccine (HD) versus standard-dose influenza vaccines (SD) in preventing hospitalization...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Purpose: The current World Health Organization (WHO) severe acute respiratory illness (SARI) case definition for global influenza surveillance includes hospitalized individuals with fever and cough, with onset within 10 days. In the South Africa pneumonia surveillance programme, we enrol individuals irrespective of symptom duration; however, the characteristics of influenza patients with chronic symptoms have not been described.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 08.006 Source Type: research
Respiratory viral infections due to community-acquired respiratory viruses (CARVs) including respiratory syncytial virus (RSV), influenza, parainfluenza virus (PIV) and human metapneumovirus (hMPV) are detected in up to 40% of allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients, in whom they may cause severe disease such as bronchiolitis and pneumonia that can be fatal. Given the lack of approved antiviral agents for these CARVs and our data demonstrating that adoptively transferred ex vivo-expanded virus-specific T cells (VSTs) can be clinically beneficial for the treatment of both latent [Epstein-Barr vi...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 544 Source Type: research
AbstractPurposeSevere community-acquired pneumonia (SCAP) is still associated with substantial morbidity and mortality. In this point-of-view review paper, a group of experts discuss the main controversies in SCAP: the role of severity scores to guide patient settings of care and empiric antibiotic therapy; the emergence of pathogens outside the core microorganisms of CAP; viral SCAP; the best empirical treatment; septic shock as the most lethal complication; and the need for new antibiotics.MethodsFor all topics, the authors describe current controversies and evidence and provide recommendations and suggestions for future...
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research
Leili Jia, Jiangyun Zhao, Chaojie Yang, Yuan Liang, Pengwei Long, Xiao Liu, Shaofu Qiu, Ligui Wang, Jing Xie, Hao Li, Hongbo Liu, Weiguang Guo, Shan Wang, Peng Li, Binghua Zhu, Rongzhang Hao, Hui Ma, Yong Jiang, Hongbin Song
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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