Under New Guidelines, More Kids Have Hypertension

New hypertension guidelines issued by the American Academy of Pediatrics in 2017 lowered the threshold for a diagnosis of high blood pressure in those under 19 years of age, and that means 795,000 more children are now classified as having the condition than before.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Publication date: April 2019Source: Redox Biology, Volume 22Author(s): Daniel S. de Jesus, Evan DeVallance, Yao Li, Micol Falabella, Danielle Guimaraes, Sruti Shiva, Brett A. Kaufman, Mark T. Gladwin, Patrick J. PaganoAbstractPulmonary arterial hypertension (PAH) is a complex degenerative disorder marked by aberrant vascular remodeling associated with hyperproliferation and migration of endothelial cells (ECs). Previous reports implicated bone morphogenetic protein antagonist Gremlin 1 in this process; however, little is known of the molecular mechanisms involved. The current study was designed to test whether redox signal...
Source: Redox Biology - Category: Biology Source Type: research
Authors: Shi S, Li S, Li W, Xu H Abstract Corn silk, a traditional Chinese medicine, has been found to exert an antihypertensive effect in clinical practice and trials. However, systematic review of current evidence on this topic was not available. Thus, this study aims to assess safety and efficacy of corn silk tea (CST) in improving clinical outcomes in patients with hypertension. A systematic literature search was conducted through popular electronic databases up to October 2018. Randomized controlled trials (RCTs) comparing CST plus conventional antihypertensive drugs with conventional antihypertensive drugs al...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Abstract The stroke-prone spontaneously hypertensive rat (SHRSP) suffers from severe hypertension and hypertensive organ damage such as cerebral stroke and kidney injury under salt-loading. By a quantitative trait locus (QTL) analysis between SHRSP and SHR (the stroke-resistant parental strain of SHRSP), two major QTLs for stroke susceptibility were identified on chromosomes 1 and 18 of SHRSP, which were confirmed in congenic strains constructed between SHRSP and SHR. As the progression of renal dysfunction was suggested to be one of the key factors inducing stroke in SHRSP, we examined effects of the stroke-relat...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
The objective of this study was to evaluate machine-learning algorithms for accurately predicting short-term outcomes after ORIF for ankle fractures. The Nationwide Inpatient Sample and Nationwide Readmissions Database were queried for adult patients ≥18 years old who underwent ORIF of an ankle fracture during 2013 or 2014. Morbidity and mortality, length of stay>3 days, and 30-day all-cause readmission were the outcomes of interest. Two machine-learning models were created to identify patient and hospital characteristics associated with the 3 outcomes. The machine learning models were evaluated using confusion matri...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
Publication date: Available online 22 February 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): María M. Adeva-Andany, Julia Martínez-Rodríguez, Manuel González-Lucán, Carlos Fernández-Fernández, Elvira Castro-QuintelaAbstractDiabetes is a common metabolic disorder associated to elevated cardiovascular morbidity and mortality that is not explained by hyperglycemia or traditional cardiovascular risk factors such as smoking or hypercholesterolemia. Intensive glycemic control with insulin that achieves near-normal glycemia does not reduce s...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 23 February 2019Source: International Journal of PharmaceuticsAuthor(s): Marwah Aljohani, Pól MacFhionnghaile, Patrick McArdle, Andrea ErxlebenAbstractThe antidiabetic drug gliclazide (GLZ) has a slow absorption rate and a low bioavailability due to its poor solubility. GLZ is often prescribed along with an antihypertensive, as many diabetic patients have coexistent hypertension. Cocrystallization and coamorphization are attractive strategies to enhance dissolution rates and to reduce the number of medications a patient has to take. In this work the formation of cocrystals and coam...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
ConclusionXMJ had satisfactory hypotensive action on the SHR in this study. Its mechanism may be associated with inhibiting RAAS activity and improving RAAS function, inhibiting hypertensive-induced vascular diastolic dysfunction, and improving vascular endothelial function.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
HIGH BLOOD pressure affects more than a quarter of adults in the UK, but many don ’t know they have it. The condition can lead to heart attacks and strokes if left untreated so it’s essential to get your blood pressure checked. If you experience any of these symptoms of severe hypertension, see a GP immediately.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusions: The developed web DB system contributed to improve the health condition of the health program participants by providing necessary information to the health professionals at the right time. This case report could be a reference for other researcher to develop web databases for their own context, especially in developing countries. PMID: 30788180 [PubMed]
Source: Healthcare Informatics Research - Category: Information Technology Tags: Healthc Inform Res Source Type: research
Pediatric hypertension (HTN) is commonly due to secondary causes such as renal parenchymal disease or renal artery stenosis (RAS). But, the impact of accessory renal arteries on the renin-angiotensin-aldosterone feedback system and potential for causing HTN is not known. First proposed by Glodny et al in 2001, parenchyma supplied by ‘accessory’ vessels may have lower blood pressure (BP) than the dominant renal parenchyma triggering renin secretion. The purpose of this study is to evaluate the safety and efficacy of accessory renal artery embolization (ARAE) in children presenting with suspected renal artery HTN.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Scientific Session 5: You ’ve Got To Be Kid-ing Me (Pediatric IR) Source Type: research
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