Synergic Effects of CD40 and CD86 Silencing in Dendritic Cells on the Control of Allergic Diseases

Conclusions: These results indicate, for the first time, that siRNA-induced CD40/CD86-silenced antigen-specific DCs have greater inhibitory effects against allergic responses than those of CD40- or CD86-silenced antigen-specific DCs alone. This study also suggests that the synergic effects of gene silencing in DCs by ≥2 siRNAs are useful for the control of allergic diseases. Thus, owing to the synergistic effects, CD40 and CD86 silencing has the potential to substantially improve the treatment of allergic diseases.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research

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ConclusionsIn persistent AR despite consistent ICS use, nasal symptoms may be the dominant drivers of AR-associated decreased general health-related QOL in contrast to persistent AR on no medication, when extranasal symptoms of AR are most significant. Longitudinal study is needed to investigate whether these results are predictive of responsiveness to ICS.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
Conclusions: Since the AR accuracy of the questionnaire is about 60%, it should be considered that the questionnaire based survey overestimates the true prevalence of AR in Korean children.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Conclusions: Allergy risk factors, especially those predisposing to allergic rhinitis, include not only genetic factors but also the mode of delivery: vaginal delivery or Cesarean section. PMID: 30008644 [PubMed]
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
Conclusion: For patients with Japanese cedar pollen-induced allergic rhinitis, the fluctuation of daily pollen dispersal had a minimal effect on the severity of symptoms during the late period. SLIT was remarkably effective in alleviating symptoms during this period but not in the early period.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: This study confirmed a high prevalence of pollen allergy among German athletes. The majority of allergic rhinitis athletes were undertreated and the reason could be their reservations about allergy treatments. Pollen allergy tremendously reduced sports performance of athletes during the pollen season. This impact can be lessened with proper treatment such as immunotherapy. Better understanding of available treatment modalities should be provided to patients and physicians to improve sports performance of athletes suffering from pollen allergy. PMID: 30009588 [PubMed - as supplied by publisher]
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
AbstractPurpose of reviewPeptide immunotherapy with synthetic peptide immuno-regulatory epitopes (SPIREs) is a safer alternative to conventional allergen immunotherapy (AIT) owing to the reduced risk of IgE-mediated adverse reactions and shorter treatment schedules. Over the last 5  years, significant advances have been made in evaluating SPIREs for the treatment of allergic rhinitis. This review includes a summary of recent phase II and III clinical trials evaluating the efficacy of SPIREs and a brief discussion on their mechanism of action.Recent findingsTo date, SPIREs have been developed for cat, house dust mite (...
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research
Researchers have discovered new risk genes for hay fever in the largest genetic study on this type of allergy.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
(University of Copenhagen The Faculty of Health and Medical Sciences) In a large international study involving almost 900,000 participants, researchers from the University of Copenhagen and COPSAC have found new risk genes for hay fever. It is the largest genetic study so far on this type of allergy, which affects millions of people around the world.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Recent advances have led to a better understanding of the pathophysiology, diagnosis, and treatment of local allergic rhinitis. Find out what there is to know.Current Opinion in Allergy and Clinical Immunology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Allergy & Clinical Immunology Journal Article Source Type: news
The objectives of this article are to review the available literature regarding the geographic distribution of nettle, allergen(s) involved, cross-reactivity, role in allergic rhinitis, immunotherapy efficacy, and provide a clinical perspective on the evaluation and treatment of nettle sensitized patients.Recent findingsStinging nettle (Urtica dioica) is a bi-annual pollinator with worldwide distribution and wide use in homeopathy. Limited data suggest that nettle pollen allergens may be considered clinically relevant and that nettle pollen allergy may be underestimated. More recent allergomic analysis of nettle pollen has...
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research
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