Synergic Effects of CD40 and CD86 Silencing in Dendritic Cells on the Control of Allergic Diseases

Conclusions: These results indicate, for the first time, that siRNA-induced CD40/CD86-silenced antigen-specific DCs have greater inhibitory effects against allergic responses than those of CD40- or CD86-silenced antigen-specific DCs alone. This study also suggests that the synergic effects of gene silencing in DCs by ≥2 siRNAs are useful for the control of allergic diseases. Thus, owing to the synergistic effects, CD40 and CD86 silencing has the potential to substantially improve the treatment of allergic diseases.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research

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ConclusionIn this series, 4% was the cutoff point for the number of eosinophils in the nasal lavage, for atopy differentiation. Upper airway remodeling accessed by basement membrane thickness showed similar inflammatory cell infiltrate in the nasal lavage, regardless of the presence of atopy.ResumoIntroduçãoA extensão da lesão epitelial na rinite alérgica e não alérgica e sua associação com alterações inflamatórias no lavado nasal, ainda não estão esclarecidas.ObjetivoVerificar a relação entre o processo inflamat...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
AbstractPurpose of ReviewMost children and adolescents with allergic rhinitis (AR) present extra-nasal multimorbid conditions, including conjunctivitis, asthma, atopic dermatitis, rhinosinusitis, or seromucous otitis. Additionally, they may present nasal obstructive disorders, such as septal deformity, turbinate enlargement, and adenoidal hyperplasia, which worsen nasal symptoms, especially nasal obstruction. This is a narrative review on the current state of the concomitant presence of AR and one or more multimorbidities.Recent FindingsThe presence of AR and one or more accompanying multimorbidities is associated to a hig...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
Grains can play havoc with your skin. The prolamin proteins, such as gliadin,  trigger autoimmune skin reactions and turn antibodies against the skin enzymes, their lectins fan the fires of inflammation, their proteins provoke allergies, and their amylopectins send blood sugar and insulin sky-high and provoke the skin-disrupting hormone insulin-like growth factor-1 (IGF). The whole grain package adds up to an impressive collection of skin conditions that can take a variety of forms, from simple red, itchy rashes to scaly, oily raised patches to large vesicles to gangrene. B...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates Source Type: blogs
Grains can play havoc with your skin. The prolamin proteins, such as gliadin,  trigger autoimmune skin reactions and turn antibodies against the skin enzymes, their lectins fan the fires of inflammation, their proteins provoke allergies, and their amylopectins send blood sugar and insulin sky-high and provoke the skin-disrupting hormone insulin-like growth factor-1 (IGF). The whole grain package adds up to an impressive collection of skin conditions that can take a variety of forms, from simple red, itchy rashes to scaly, oily raised patches to large vesicles to gangrene. B...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates Source Type: blogs
Publication date: Available online 20 February 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Moises A. Calderón, Thomas B. Casale, Pascal DemolyAlthough regulatory authorities have recently recommended the use of a combined symptom-medication score as a primary efficacy end point, none has been psychometrically validated. Here, we sought to determine to what extent allergic rhinitis (AR)-related patient-reported outcomes (symptom scores, medication scores, disease control scores, and satisfaction or quality-of-life scales) have been assessed for construct, content, and/or criterio...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
The defect of Tfr cells may contribute to aberrant IgE production in AR patients. The improvement of Tfr cells correlates with the clinical benefits of AIT in AR patients.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
A growing use of complementary alternative medicine (CAM) has been found in Europe as well in Italy for chronic diseases, including the allergic rhinitis. The study aims at investigating the prevalence and the...
Source: Clinical and Molecular Allergy - Category: Allergy & Immunology Authors: Tags: Research Source Type: research
Sensitization to common environmental aeroallergens plays a significant role in the pathogenesis and severity of respiratory allergic disorders, specifically asthma and allergic rhinitis. Understanding sensiti...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Research Source Type: research
CONCLUSIONS: Results clearly overturned our hypothesis about the possibility of using FXF to block over-expression HRH-4 and open new way of treatment in allergy diseases. PMID: 30742585 [PubMed - in process]
Source: Journal of Pharmacy and Pharmaceutical Sciences - Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research
This study aimed to establish a relationship between polysensitization and allergic multimorbidity in children and adults and the allergens involved in multimorbidity.Material and methodA cross-sectional multicentre study enrolled children aged 6 –7 and 13–14 years and adults aged 20–44 years from a Polish national cohort. The diagnosis of allergic diseases was made by a physician. Skin prick tests to 13 allergens and serum IgE levels to 4 allergens were tested.ResultsAmong the 3856 participants, single disease (asthma, allergic rhinitis or atopic dermatitis) was diagnosed in 27.7% subjects and ...
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
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