Researchers Probe Autism's Origins in the Brain

Researchers are looking for clues to autism in the structure of the brain, specifically the cerebellum.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 10 November 2018Source: Pharmacological ResearchAuthor(s): Valentina R. Garbarino, Taylor A. Santos, Anastassia R. Nelson, Wynne Q. Zhang, Corey M. Smolik, Martin A. Javors, Lynette C. Daws, Georgianna G. GouldAbstractPoorly managed gestational diabetes can lead to severe complications for mother and child including fetal overgrowth, neonatal hypoglycemia and increased autism risk. Use of metformin to control it is relatively new and promising. Yet safety concerns regarding gestational metformin use remain, as its long-term effects in offspring are unclear. In light of beneficial findings...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 10 November 2018Source: NeuroscienceAuthor(s): Abbey J. Herringshaw, Sandhya L. Kumar, Kaitlyn Noel Rody, Rajesh K. KanaAbstractThe Weak Central Coherence account of autism spectrum disorders posits that individuals with ASD utilize a detail-oriented information processing bias. While this local bias is helpful in visual search tasks, ASD individuals falter in social cognition tasks where coherence is advantageous. The present study examined the neural correlates of Weak Central Coherence in ASD during visual and social processing. Fifteen ASD and sixteen typically developing children/ado...
Source: Neuroscience - Category: Neuroscience Source Type: research
ConclusionFolate transporter deficiency has a wide range of presenting symptoms. Presentation with slowly progressive atypical symptoms, stable white matter changes in brain MRI that does not fit a specific diagnosis, should raise a high suspicion of FOLR1 mutation, even in absence of seizures. Since folate transporter deficiency is a treatable neurodegenerative disorder, early diagnosis and supplementation with folinic acid is vital.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 9 November 2018Source: Pharmacology Biochemistry and BehaviorAuthor(s): Haruki Kawase, Yukio Ago, Megumi Naito, Momoko Higuchi, Yuta Hara, Shigeru Hasebe, Shinji Tsukada, Atsushi Kasai, Takanobu Nakazawa, Tadashi Mishina, Hiroyuki Kouji, Kazuhiro Takuma, Hitoshi HashimotoAbstractGrowing evidence suggests pivotal roles for epigenetic mechanisms in both animal models of and individuals with autism spectrum disorders (ASD). Neuron-restrictive silencer factor (NRSF) binds to neuron-restrictive silencing elements in neuronal genes and recruits co-repressors, such as mSin3, to epigenetically in...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
Parents of 5- to 12-year-old children (half had been diagnosed with autism spectrum disorder [ASD] and half were typically developing) provided reports of the most significant marital conflict of the day and ratings of child behaviors problems on a daily b...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Individuals with autism spectrum disorder (ASD) are at heightened risk of psychiatric comorbidities across the lifespan, including elevated rates of internalizing, externalizing, and self-injurious behaviors. Identification of medical comorbidities that co...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
This article is protected by copyright. All rights reserved. PMID: 30414172 [PubMed - as supplied by publisher]
Source: Clinical Genetics - Category: Genetics & Stem Cells Authors: Tags: Clin Genet Source Type: research
DiscussionIt is important to develop a more granular understanding of patients at risk of requiring involuntary treatment and to determine how best to treat them effectively with minimal use of involuntary measures.
Source: International Journal of Eating Disorders - Category: Eating Disorders & Weight Management Authors: Tags: ORIGINAL ARTICLE Source Type: research
In a new paper published today, US and German scientists say they have evidence that zinc levels may be one of the defining environmental factors that sew the seeds of the behavioral disorder.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
A link between zinc deficiency and the development of autism has been confirmed in a study of brain cells' connections from rats' hippocampal neurons.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
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