Researchers Probe Autism's Origins in the Brain

Researchers are looking for clues to autism in the structure of the brain, specifically the cerebellum.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Franco De Crescenzo, Valentina Postorino, Martina Siracusano, Assia Riccioni, Marco Armando, Paolo Curatolo, Luigi Mazzone
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
AbstractNeuroligins (NLs) are postsynaptic cell-adhesion proteins that play important roles in synapse formation and the excitatory-inhibitory balance. They have been associated with autism in both human genetic and animal model studies, and affect synaptic connections and synaptic plasticity in several brain regions. Yet current research mainly focuses on pyramidal neurons, while the function of NLs in interneurons remains to be understood. To explore the functional difference among NLs in the subtype-specific synapse formation of both pyramidal neurons and interneurons, we performed viral-mediated shRNA knockdown of NLs ...
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research
Autistic kids that suffer from phobias have a particularly hard time overcoming their fears. Traditional therapies don’t work well, so researchers at Newcastle University in England have been testing an immersive virtual reality system that is ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Pediatrics Psychiatry Source Type: blogs
Conditions:   Autism Spectrum Disorder;   Developmental Delay Interventions:   Other: Telemedicine - Screening Tool for Autism in Toddlers (STAT);   Other: Telemedicine - Autism Spectrum Disorder - Pediatrics (ASD-PEDS) Sponsors:   Vanderbilt University Medical Center;   National Institute of Mental Health (NIMH) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: 19 February 2019Source: Cell Reports, Volume 26, Issue 8Author(s): Elizabeth C. Davenport, Blanka R. Szulc, James Drew, James Taylor, Toby Morgan, Nathalie F. Higgs, Guillermo López-Doménech, Josef T. KittlerSummaryAltered excitatory/inhibitory (E/I) balance is implicated in neuropsychiatric and neurodevelopmental disorders, but the underlying genetic etiology remains poorly understood. Copy number variations in CYFIP1 are associated with autism, schizophrenia, and intellectual disability, but its role in regulating synaptic inhibition or E/I balance remains unclear. We show that CYFIP1, and...
Source: Cell Reports - Category: Cytology Source Type: research
Immersive virtual reality is playing a key role in the provision of NHS services to help treat anxieties and phobias.
Source: mobihealthnews - Category: Information Technology Source Type: news
Asperger's Children: The Origins of Autism in Nazi Vienna By Edith Sheffer. W.W. Norton and Company. 2018. 320 pp. £18.99 (hb). ISBN 9780393609646. Br J Psychiatry. 2019 Mar;214(3):176 Authors: Rubinsztein JS PMID: 30774062 [PubMed - in process]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
Authors: Gyawali S, Patra BN Abstract Autism Spectrum Disorder is a neurodevelopmental disorder characterized by persistent deficits in social communication, social interaction and restricted, repetitive patterns of behavior, interests or activities. The concept of autism has changed since its inception, from childhood schizophrenia to neuro-variation. These changes in concept have been accompanied by changes in the diagnostic threshold through which the 'case' of autism is identified. The occurrence of multiple changes in its diagnostic criteria over last 80 odd years opens up the possibility of challenges being p...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
ABSTRACTAutism spectrum disorder (ASD) is a complex neurodevelopmental disorder with impairments in social communication, restricted, repetitive and stereotyped behaviors. Both genetic and environmental factors are known to contribute toward pathophysiology of Autism. Environmental influences on gene expression can be mediated by methylation patterns which are established and maintained by DNA methyltransferases. Several studies in the past have investigated the role of global methylations in Autism. The present study is aimed to investigate the role of genetic variations in the DNA methyltransferase which might be critica...
Source: IUBMB Life - Category: Research Authors: Tags: Research Communication Source Type: research
ConclusionsThe evidence for equine ‐assisted interventions for adults and children across a range of conditions and presentations is equivocal. The current evidence base is marred by multiple methodological weaknesses and thus, therapeutic interventions that include a horse cannot be asserted as best practice at this time. Rigorous research is indicated to determine the utility of equine‐assisted interventions.
Source: Australian Journal of Psychology - Category: Psychiatry & Psychology Authors: Tags: SPECIAL ISSUE Source Type: research
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