Effect of cumulative intravenous voriconazole dose on renal function in hematological patients.

Effect of cumulative intravenous voriconazole dose on renal function in hematological patients.
Antimicrob Agents Chemother. 2018 Jul 09;:
Authors: Yasu T, Konuma T, Kuroda S, Takahashi S, Tojo A
Abstract
The intravenous voriconazole (VRC) is formulated by the incorporation of sulfobutylether-β-cyclodextrin (SBECD), which may accumulate to adversely affect renal function. However, the effect of long-term use of intravenous VRC on renal function is unclear. Our retrospective data confirmed that worsening of renal function was significantly associated with cumulative dose of intravenous VRC (≥ 400mg/kg), suggesting that a higher cumulative dose of intravenous VRC was a risk factor for renal dysfunction.
PMID: 29987145 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - July 9, 2018 Category: Microbiology Authors: Yasu T, Konuma T, Kuroda S, Takahashi S, Tojo A Tags: Antimicrob Agents Chemother Source Type: research