Heat-shock transcription factor 1 is critically involved in the ischaemia-induced cardiac hypertrophy via JAK2/STAT3 pathway.

Heat-shock transcription factor 1 is critically involved in the ischaemia-induced cardiac hypertrophy via JAK2/STAT3 pathway. J Cell Mol Med. 2018 Jul 11;: Authors: Yuan L, Qiu L, Ye Y, Wu J, Wang S, Wang X, Zhou N, Zou Y Abstract Cardiac hypertrophy after myocardial infarction (MI) is an independent risk factor for heart failure. Regression of cardiac hypertrophy has emerged as a promising strategy in the treatment of MI patients. Here, we have been suggested that heat-shock transcription factor 1 (HSF1) is a novel repressor of ischaemia-induced cardiac hypertrophy. Ligation of left anterior descending coronary was used to produce MI in HSF1-deficient heterozygote (KO), HSF1 transgenic (TG) mice and their wild-type (WT) littermates, respectively. Neonatal rat cardiomyocytes (NRCMs) were treated by hypoxia to mimic MI in vitro. The HSF1 phosphorylation was significantly reduced in the infarct border zone of mouse left ventricles (LVs) 1 week after MI and in the hypoxia-treated NRCMs. HSF1 KO mice showed more significant maladaptive cardiac hypertrophy and deteriorated cardiac dysfunction 1 week after MI compared to WT MI mice. Deficiency of HSF1 by siRNA transfection notably increased the hypoxia-induced myocardial hypertrophy in NRCMs. Mechanistically, Janus kinase 2 (JAK2) and its effector, signal transducer and activator of transcription 3 (STAT3) were found to be significantly increased in the LV infarct border zone of WT mice after MI as well as the...
Source: J Cell Mol Med - Category: Molecular Biology Authors: Tags: J Cell Mol Med Source Type: research

Related Links:

Abstract Patients with heart failure (HF) syndromes have been categorized as those with reduced ejection fraction (EF) or preserved EF (HFpEF), and ischemia plays a key role in both types. HF remains a major cause of morbidity and mortality worldwide, and with the aging of our population this burden continues to rise, predominantly as a result of hospitalizations for HFpEF. Patients with obstructive coronary artery disease more likely have HF with reduced EF, rather than HFpEF, secondary to acute ischemic injury resulting in myocardial infarction, and large outcomes trials of treatments with neurohumoral inhibitio...
Source: Circulation Research - Category: Cardiology Authors: Tags: Circ Res Source Type: research
In conclusion, in-hospital clinical outcomes were poorer in the RVI group than in the non-RVI group. However, mid-term MACE was not different between the two groups, suggesting the importance of aggressive acute treatment for STEMI patients with RVI. PMID: 31105155 [PubMed - as supplied by publisher]
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
(University of Houston) A University of Houston College of Pharmacy researcher is examining the fight or flight hormones as an avenue to increase heart function following a heart attack, helping alleviate the symptoms of heart failure.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionsAmong patients with T2DM after a recent ACS or AIS, treatment with vildagliptin was not associated with increased risks of CV death, nonfatal MI, nonfatal stroke, and hospitalization for HF.This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Original Article Source Type: research
ABSTRACT Adult mammalian heart repair after myocardial damage is highly inefficient due to the post-mitotic nature of cardiomyocytes. Interestingly, in Traditional Chinese Medicine (TCM), there are reported effective treatments of myocardial infarction and heart failure in adult humans by oral intake of a TCM concoction named Gu Ben Pei Yuan San (GBPYS) which is composed of Panax ginseng, Velvet antler, Gekko gecko linnaeus tail, Human placenta, Trogopterus dung, Panax notoginseng, and Amber. We fed the mice with GBPYS after myocardial damages through everyday self-feeding. We then examined the effect of everyday oral int...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
GPs need better access to diagnostic tests Related items fromOnMedica Test could tackle underdiagnosis of MI in women Hospitals fail women with myocardial infarction Oxygen therapy after heart attack does not prevent heart failure New ‘treadmill test’ can predict mortality Women less likely than men to achieve CHD targets
Source: OnMedica Latest News - Category: UK Health Source Type: news
Study finds unequal treatment for men and women Related items fromOnMedica Heart attack protocol eliminates gender gap in outcome Erectile dysfunction increases cardiovascular risk Meaty diet linked to heart failure risk Ignored cholesterol blamed for heart attacks Shoulder replacement surgery carries higher risk
Source: OnMedica Latest News - Category: UK Health Source Type: news
(Baylor College of Medicine) Two blood proteins help predict more accurately the risk for heart attack, stroke and heart failure hospitalization.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
The improvement achieved in recent years in early myocardial infarction (MI) mortality poses several new clinical challenges, owing to late consequences of myocardial loss and the significant incidence of heart failure (HF) observed thereafter. A still unaddressed residual reperfusion injury (RI) contributes to final infarct size, acute MI mortality and longer-term HF development. Despite many cardioprotective lines of research in the setting of MI, no treatment has significantly altered clinical practice or convincingly improved outcomes either.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
More News: Cardiology | Heart | Heart Attack | Heart Failure | Molecular Biology | Perinatology & Neonatology