Rho GTPases are involved in S1P-enhanced glomerular endothelial cells activation with anti-myeloperoxidase antibody positive IgG.

In this study, we demonstrated that Rho guanosine triphosphatases (GTPases) signalling pathways, RhoA and Rac1 in particular, were implicated in MPO-ANCA-positive IgG-mediated GEnCs activation enhanced by pathophysiological concentration of S1P in AAV. These results provide mechanistic insights into vascular barrier dysfunction in AAV, which may facilitate the development of effective therapies.
PMID: 29993181 [PubMed - as supplied by publisher]

Source: J Cell Mol Med - July 11, 2018 Category: Molecular Biology Authors: Sun XJ, Chen M, Zhao MH Tags: J Cell Mol Med Source Type: research