A Useful marker in the assessment of remission and activation of disease in patients with rheumatoid arthritis: Serum human neutrophil peptides 1-3.

CONCLUSION: In the present study, patients with an active disease had significantly higher serum HNP 1-3 levels compared to patients in remission. In this respect, serum HNP 1-3 can be a useful marker in the assessment of disease activity and remission in patients with RA. PMID: 29991120 [PubMed - as supplied by publisher]
Source: Journal of Back and Musculoskeletal Rehabilitation - Category: Orthopaedics Tags: J Back Musculoskelet Rehabil Source Type: research

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Publication date: Available online 19 November 2018Source: Brain, Behavior, and ImmunityAuthor(s): Sarah A. Woller, Cody Ocheltree, Stephanie Y. Wong, Anthony Bui, Yuya Fujita, Gilson Gonçalves dos Santos, Tony L. Yaksh, Maripat CorrAbstractIn rheumatoid arthritis, joint pain can persist despite resolution of swelling. Similarly, in the murine K/BxN serum transfer model, a persistent tactile allodynia is observed after the resolution of joint inflammation (post-inflammatory pain) in male mice. Here, we found female wild type (WT) mice show inflammatory, but reduced post-inflammatory tactile allodynia. The transition...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractAimDiscrepancies exist between international treatment guidelines and current Australian Pharmaceutical Benefits Scheme (PBS) criteria for funding biologic disease ‐modifying antirheumatic drug (bDMARD) prescribing in psoriatic arthritis (PsA). We aimed to determine the prevalence of minimal disease activity (MDA) achievement and differences in inflammatory marker levels between PsA patients who have and have not met the Australian PBS criteria for bDMARDs.MethodConsecutive participants diagnosed with PsA were assessed for MDA components and serum inflammatory markers. For those on bDMARDs, joint counts and infla...
Source: APLAR Journal of Rheumatology - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractObjectivesTo study clinical and patient reported outcomes for the Virtual Monitoring Clinic (VMC), a remote nurse ‐led telemonitoring service for monitoring Rheumatoid Arthritis (RA) patients treated with disease‐modifying antirheumatic drugs (DMARDs).MethodsPatients with stable RA enrolled in the VMC were followed up prospectively. The primary outcomes evaluated at 1 ‐year follow‐up were: Disease Activity Score‐28 (DAS28), Routine Assessment of Patient Index Data 3 (RAPID3), and patient satisfaction assessed using an 11‐point Likert scale.ResultsOf the 251 patients enrolled, 186 completed 1 ‐year of ...
Source: APLAR Journal of Rheumatology - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
This article reviews the new developments in RA research and discusses the latest insights into epidemiology, risk factors, predisease states, and outcomes.
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Authors: Ciechanowicz P, Rakowska A, Sikora M, Rudnicka L Abstract The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway is a ubiquitous intracellular signaling network. Selective JAK-inhibitors have anti-inflammatory properties and have been approved in many countries for the treatment of rheumatoid arthritis (tofacitinib, baricitinib) and myelofibrosis or polycythemia vera (ruxolitinib). The aim of the publication was to summarize and critically analyze the efficacy and safety of JAK-inhibitors in skin diseases, such as psoriasis, alopecia areata, atopic dermatitis and vitilig...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Publication date: Available online 16 November 2018Source: Journal of the Saudi Heart AssociationAuthor(s): Mohamed Naseem, Sameh Samir, Ibtsam Khairat Ibrahim, Lamiaa Khedr, Abeer Abd Elmonem ShahbaAbstractObjectivesDisease activity has been considered as an independent cardiovascular risk factor in patients with rheumatoid arthritis (RA). We aimed to evaluate the effect of RA disease activity on left ventricular (LV) and right ventricular (RV) functions by speckle tracking echocardiography (STE).MethodsA total of 120 RA patients without evidence of cardiovascular disease and 40 healthy control individuals were included i...
Source: Journal of the Saudi Heart Association - Category: Cardiology Source Type: research
We describe a case of MTX-LPD of the stomach. After treatment with methotrexate for rheumatoid arthritis, the patient developed left cervical lymphadenopathy and an ulcerative lesion in the stomach, which was presumed to be a mucosa-associated lymphoid tissue (MALT) lymphoma. However, we suspected MTX-LPD, based on the clinical course and the positivity of in situ hybridization for the detection of the Epstein-Barr encoding region. After the cessation of MTX, the left cervical lymphadenopathy and the gastric lesion disappeared. This is first report of gastric MTX-LPD that was presumed to be MALT lymphoma. PMID: 3042943...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Ishii K, Hatori K, Takeichi O, Makino K, Himi K, Komiya H, Ogiso B Abstract It has been reported that Forkhead box transcription factor class O3a (Foxo3a) is expressed in rheumatoid arthritis, a chronic inflammatory condition accompanied by bone resorption, and plays a role in its pathology. However, it has remained unclear whether Foxo3a is involved in the pathogenesis of periapical granulomas. The present study was performed to compare the expression of Foxo3a in periapical granulomas and healthy gingival tissues. Samples were obtained surgically from patients, and subjected to hematoxylin-eosin staining...
Source: Journal of oral science - Category: Dentistry Tags: J Oral Sci Source Type: research
This study presents a case series study of a new technique for ligament balancing wherein the collateral ligament is detached from its origin and rotated (twisted) around its longitudinal axis to tighten the ligament before the origin is reattached to its original position. The surgical technique for collateral ligament tightening during TKR was performed on 6 patients with a deformed knee caused by osteoarthritis and rheumatoid arthritis. The range of motion, knee society score, and laxity of the patients’ knee joint, after 7 months to 13 years of follow-up, were evaluated. The technique was successful, achieving go...
Source: Techniques in Orthopaedics - Category: Orthopaedics Tags: Special Technical Articles Source Type: research
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