Tributyltin and Vascular Dysfunction: The Role of Oxidative Stress
Karoline de Sousa Ronconi, Ivanita Stefanon, Rogerio F. Ribeiro Junior
In this study, we have systematically reviewed the relationships between KS and the cardiovascular system and the management of cardiovascular complication. In summary, patients with KS display increased cardiovascular risk profile, characterized by increased prevalence of metabolic alterations including dyslipidemia, diabetes mellitus (DM), and abnormalities in biomarkers of cardiovascular disease. KS subjects are characterized by subclinical abnormalities in endothelial function and in left ventricular (LV) systolic and diastolic function, which - when associated with chronotropic incompetence - may negatively influence ...
Authors: Bereket A PMID: 30786706 [PubMed - in process]
Conclusions: In patients with cirrhosis, those with concurrent elevation of HVPG and LS had the highest long-term mortality rates. However, when either HVPG or LS alone was elevated, mortality did not increase significantly. PMID: 30791681 [PubMed - as supplied by publisher]
Publication date: Available online 22 February 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Lale Nazari, Maryam MehrabiAbstractThe current study examines a thermotolerant alkaliphilic serine protease from newly isolated Bacillus sp. DEM07, which was purified with a 20% total protein yield and 14.28 fold purification. The molecular weight of the enzyme was estimated to be 27.5 kDa. The Km and Vmax values of the purified enzyme were found to be 0.06 mg/ml and 1.25 μmol/min, respectively. The enzyme maintained activity and stability over the 30–55 °C temperature range exhibiting its o...
Authors: Qureshi AA, Friedman AJ Abstract Since the first reported cases in 2007, idiopathic mast cell activation syndrome has been increasingly recognized. Understanding of the cutaneous manifestations of this condition is imperative for dermatologists given the substantial clinical heterogeneity in its presentation and high estimated prevalence. A review of PubMed® and SCOPUS® databases was performed in order to investigate the most common dermatologic manifestations of idiopathic mast cell activation syndrome. Evidence to date suggests that flushing, pruritus, and clotting dysfunction or bleeding disorde...
Conclusion: Topical minoxidil is efficacious for the treatment of hair loss due to male and female androgenic alopecia, alopecia areata, with case-by-case application for traction alopecia, hair transplantation, and congenital hair disorders. Combination therapies using minoxidil with systemic, topical, and injectable therapies demonstrate increased effectiveness over monotherapies. J Drugs Dermatol. 2019;18(2):155-160. PMID: 30794366 [PubMed - as supplied by publisher]
Authors: Frost ML, Hrynewycz K, Hanke CW Abstract Tumor thickness has been a key tool for prognosis of melanoma. However, with the advent of gene expression profile (GEP) assays for melanoma and the discovery of multiple melanoma subtypes, it is time to reassess how we view tumor thickness as a prognostic indicator.Herein we present ten questions for consideration by the shrewd practitioner when considering prognostic factors of melanoma. J Drugs Dermatol. 2019;18(2):148-151. PMID: 30794365 [PubMed - as supplied by publisher]
Authors: Draelos ZD, Gunt H, Levy SB Abstract Background: Rosacea is characterized by irritation associated with erythema, telangiectasias and papules/pustules. Whole formula nature-based sensitive skin products are formulated to maintain skin barrier and appropriate hydration that can lead to soothing benefits. Objective: To evaluate the efficacy and tolerability of a regimen consisting of a cleanser containing natural oils, beeswax, and witch hazel and day and night creams containing natural oils, glycerin, and botanical anti-inflammatories (NR); and a synthetic dermatologist-recommended regimen of cetyl alcohol...
Conclusion: The histologic findings of BCCs treated with vismodegib correlate with clinical response. J Drugs Dermatol. 2019;18(2):136-138. PMID: 30794363 [PubMed - as supplied by publisher]
Conclusions: Superficial radiation therapy is an effective option for eliminating BCC and SCC on lower extremities of patients who opt for nonsurgical treatment. Using SRT for BCC and SCC in elderly patients resulted in a 97.4% cure rate. J Drugs Dermatol. 2019;18(2):130-134. PMID: 30794362 [PubMed - as supplied by publisher]
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