Powdered insulin to prevent type-1 diabetes in children

A new clinical trial will investigate if giving powdered insulin to babies at high risk of developing type-1 diabetes can be a solution to prevent the disease.BBC News
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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James Norton, 33, who plays Sidney Chambers in Grantchester, has type 1 diabetes and has to have a glucose monitor stuck out of sight on his bottom if he is filming a topless scene.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
MONDAY, April 22, 2019 -- For women with type 1 diabetes (T1D), the risk for preterm birth is strongly associated with periconceptional hemoglobin A1c (HbA1c) level, according to a study published online April 22 in the Annals of Internal...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
AbstractPurpose of ReviewThe aims of this review are to summarize recent data on mortality and cardiovascular disease (CVD) in type 1 and type 2 diabetes and to determine the interventions that could have contributed to a reduction in mortality.Recent FindingsRecent studies found a downward trend in mortality and CVD among both diabetics and non-diabetics worldwide over the last few decades. The decline among diabetics is steeper than that among non-diabetics. Despite a parallel trend of decline, an approximately twofold difference in mortality and CVD between the two populations remains.SummaryA greater emphasis on glycem...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print
Source: Journal of Pediatric Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
Background: Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is characterized by fever, cutaneous eruptions, hematological abnormalities, organ disorder, and reactivation of human herpesvirus 6 (HHV-6). In addition, autoimmune diseases such as type 1 diabetes and thyroiditis may develop long-term after resolution of DIHS. Reactivation of HHV-6 has been reported to be involved in clinical condition of DIHS. We found that quite a few patients harbor high levels (> 1000 copies / 106 PBMC) of HHV-6 DNA in PBMC over 4 months after onset of DIHS.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, and Microbiome Source Type: research
We examined contributions of inflammatory molecules lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), stress-activated kinases (c-Jun N-terminal kinase [JNK] and p38), arginase, and reactive oxygen species to coronary arteriolar dysfunction in a porcine model of type 1 diabetes. Coronary arterioles were isolated from streptozocin-induced diabetic pigs and control pigs for vasoreactivity and molecular/biochemical studies.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research
Authors: Ghoneum MH, Gimzewski JK, Ghoneum AD, Agrawal S Abstract The hydroferrate fluid MRN-100, an iron-based compound with potent antioxidant characteristics, was examined to identify its possible anti-inflammatory effects on human dendritic cells (DCs) in vitro. Human monocyte-derived DCs were treated with MRN-100 at two concentrations (50 and 100 μL/mL) for 24 h and then stimulated with or without lipopolysaccharides (LPS). The expression of DC maturation markers was assessed by flow cytometry and the production of cytokines was determined by enzyme-linked immunosorbent assay (ELISA). Function...
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
Condition:   Coronary Artery Calcification Intervention:   Other: Data collection Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we used mice with global genetic deletion of the genes encoding 12-lipoxygenase (arachidonate 12-lipoxygenase, 12S type [Alox12]) or 12/15-lipoxygenase (Alox15) to compare the influence of each gene deletion on β cell function and survival in response to the β cell toxin streptozotocin. Alox12−/− mice exhibited greater impairment in glucose tolerance following streptozotocin exposure than WT mice, whereas Alox15−/− mice were protected against dysglycemia. These changes were accompanied by evidence of islet oxidative stress in Alox12−/− mice and reduced oxidative ...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Lipids Source Type: research
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