Role of oxidative stress in pathology of chronic prostatitis/chronic pelvic pain syndrome and male infertility and antioxidants function in ameliorating oxidative stress

Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Awais Ullah Ihsan, Farhan Ullahp Khan, Puregmaa Khongorzul, Khalil Ali Ahmad, Muhammad Naveed, Sufia Yasmeen, Yanfang Cao, Abdoh Taleb, Richinandan Maiti, Fahad Akhter, Xiaoqian Liao, Xue Li, Yijie Cheng, Hidayat Ullah Khan, Khurshid Alam, Xiaohui ZhouAbstractOxidative stress (OS) is a result of the imbalance between reactive oxygen species (ROS) and antioxidants in the body that can cause tissue damage. Oxidative stress has a significant involvement in the pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and male infertility. CP/CPPS is a major risk factor for male infertility due to generation of excessive ROS that damage sperm DNA, lipids, and proteins, resulting in compromised vitality and decreased sperm motility. Here we present a comprehensive review of oxidative stress relevance in CP/CPPS and male infertility, and embody the protective effects of antioxidants against ROS. An online literature was searched using the following keywords/terms: oxidative stress, ROS, Oxidative stress and chronic prostatitis, oxidative stress and male infertility and antioxidants. Original and review articles, clinical trials, and case reports of human and animal studies published till 2017 were searched using the PubMed and MEDLINE.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research