HUWE1 upregulation has tumor suppressive effect in human prostate cancer cell lines through c-Myc

ConclusionHUWE1 overexpression could functionally suppress CaP development bothin vitro and in vivo, possibly by inverse regulation on c-Myc.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

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In this study, we have shown that NOL8, a binding protein of beta-catenin, enhanced the interaction between beta-catenin and TCF4, and activated beta-catenin/TCF signaling. NOL8 is up-regulated in the prostate cancer, and promoted the growth, migration and colony formation of cancer cells. Knocking down the expression of NOL8 inhibited the growth, migration and colony formation of prostate cancer cells. The molecular mechanism study demonstrated that NOL8 promoted the migration and colony formation of cancer cells by activating beta-catenin/TCF signaling. Taken together, this study demonstrated the oncogenic roles of NOL8 ...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Authors: Zhang S, Cai J, Xie W, Luo H, Yang F Abstract MicroRNA (miR)-202 has been reported to be involved in the regulation of human cancer progression including bladder cancer, non-small cell lung cancer, pancreatic cancer and esophageal squamous cell carcinoma. However, the function of miR-202 in prostate cancer remains largely unknown. The present study demonstrated that miR-202 was downregulated in human prostate cancer tissues and cell lines. And overexpression of miR-202 significantly inhibited the proliferation, migration and invasion of prostate cancer cells, but induced cell apoptosis. Moreover, miR-202 s...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Publication date: Available online 17 August 2018Source: African Journal of UrologyAuthor(s): A.I. Ebeid, A.S. ElshamyAbstractObjectiveThe goal of this study was to get a better understanding the role of Power Doppler (PDUS) and conventional Gray Scale transrectal ultrasound (TRUS) in targeting prostatic biopsy in men with high prostate-specific antigen (PSA).Patients and methodsA prospective comparative study of 100 men, categorized according to PSA level into two groups: Group (A) with a PSA level (4.0–10.0) ng/ml (Gray zone) and Group (B) with PSA>10.0 ng/ml, above Gray zone. Gray Scale scanning was done, f...
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research
BACKGROUND: Whether the diagnosis of prostate cancer is a contributory psychological stress that causes excess risk of suicide among affected men remains controversial. We performed a meta-analysis of previous studies to investigate suicide incidence and a...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
AbstractImmunotherapy is rapidly transforming cancer care across a range of tumor types. Although Sipuleucel-T represented the first successful vaccine for the treatment of established cancer, other immunotherapeutic approaches for prostate cancer such as checkpoint inhibitors have been relatively disappointing to date. However, significant promise is on the horizon as there is a wide array trials evaluating immunotherapy in prostate cancer patients. These include both immune checkpoint inhibitors and antigen-specific approaches including vaccines, antibody-drug conjugates, and antitumor antibodies. Furthermore, a better u...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
Abstract Oxidative stress is a primary cause of vascular endothelial damage. In the prostate, ischemia increases the levels of reactive oxygen species, growth factors and cytokines, and induces the development of angiogenesis, which results in cancer progression. The expression levels of an oxidative stress marker, 8-hydroxyguanosine (8-OHdG), were compared between prostate cancer and non-neoplastic prostate tissues. A prostate tissue microarray composed of 10 cases of prostatic adenocarcinoma and 70 cases of benign prostatic hyperplasia was immunohistochemically stained for 8-OHdG. All cases expressed 8-OHdG. The...
Source: Clinical Prostate Cancer - Category: Cancer & Oncology Authors: Tags: Mol Clin Oncol Source Type: research
Condition:   Prostate Cancer Intervention:   Diagnostic Test: Fluciclovine PET/MRI Sponsor:   New York University School of Medicine Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Veterans who seek care for low-risk prostate cancer receive more imaging that...Read more on AuntMinnie.comRelated Reading: Can AI best quantitative MRI in prostate lesions? Multiparametric MRI aids in prostate cancer follow-up SNMMI: Early prostate cancer therapy extends lives SNMMI: Fluciclovine-PET changes prostate treatment MRI-based risk model improves prostate cancer detection
Source: Headlines - Category: Radiology Source Type: news
Condition:   Prostate Cancer Intervention:   Diagnostic Test: Fluciclovine PET/MRI Sponsor:   New York University School of Medicine Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Authors: Di Stefano C, Grazioli P, Fontanella RA, De Cesaris P, D'Amore A, Regno M, Starace D, Padula F, Fiori ME, Canipari R, Stoppacciaro A, Pesce M, Filippini A, Campese AF, Ziparo E, Riccioli A Abstract In human prostate cancer (PCa), the neuroendocrine cells, expressing the prostate cancer stem cell (CSC) marker CD44, may be resistant to androgen ablation and promote tumor recurrence. During the study of heterogeneity of the highly aggressive neuroendocrine PCa cell lines PC3 and DU-145, we isolated and expanded in vitro a minor subpopulation of very small cells lacking CD44 (CD44neg). Unexpectedly, these sort...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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