HUWE1 upregulation has tumor suppressive effect in human prostate cancer cell lines through c-Myc
ConclusionHUWE1 overexpression could functionally suppress CaP development bothin vitro and in vivo, possibly by inverse regulation on c-Myc.
ConclusionsThe EAU Prostate Cancer Centre Consensus Meeting defined the criteria for the identification of the EPCCE in the fields of clinics, research, and education. The inclusion of a quality control approach represents the novelty that supports the excellence of these centres.Patient summaryA task force of experts defined the criteria for the identification of European Prostate Cancer Centres of Excellence, in order to certify the high-quality centres for prostate cancer management.
Publication date: Available online 22 February 2019Source: European UrologyAuthor(s): John R. Prensner, Felix Y. Feng
ConclusionsThese results provide evidence that the enzalutamide/radiotherapy combination could maximize therapeutic responses in patients with enzalutamide-sensitive prostate cancer.
ConclusionsThe volume of the bladder wall decreased during IMRT. The range of subtraction of the volume of the bladder wall was extensive. Thus, the estimation of the bladder wall may be useful to reduce the inter-fraction variation.
The objective of this compound is to decrease the rate of rectal toxicity related to radiation therapy, by creating a gap between the prostate and rectum. Secondary benefits include decreased urinary complications and improved sexual quality of life. The hydrogel spacer maintains space for approximately 3 months, and is absorbed in about 6 months.
To evaluate the efficacy and clinical impact of 3 Tesla in-bore trans-rectal magnetic resonance-guided biopsy (3T MRGB) for prostate cancer (PCa) detection based on PIRADSv2 in patients with either suspected prostate cancer or under active surveillance.
We describe our experience using MRI fused CBCT guidance for prostate biopsy. There are no published reports on the use of CBCT guidance in prostate biopsies. We hypothesize this technique will have an adequate safety profile while accurately detecting prostate cancer.
To retrospectively evaluate PAE for palliation of symptoms in prostate cancer (PCa) patients who are non-surgical candidates.
Theranostic drugs under development for prostate cancer (PCa) must be tested in a large animal model prior to human clinical trials. We developed an orthotopic PCa model in dogs to target the gastrin-releasing peptide receptor (GRPR). Prostate cancer in men markedly overexpresses GRPR compared to normal or hyperplastic prostate.
Transrectal focal laser ablation (FLA) of prostate cancer in the MRI environment carries with it the risk of thermal damage to the rectal wall resulting in rectourethral fistula (RUF) formation with painful and/or prolonged cystoprostatitis. RUF ’s are treated surgically with temporary colonic diversion (colostomy) and flap interposition between the rectum and urethra which leaves the patient lifestyle limitations and often urinary incontinence. An alternative treatment for small RUF’s is a conservative medical course including weeks of urinary catheterization.