Effect of herbal mixture composed of Alchemilla vulgaris and Mimosa on wound healing process

Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Jawun Choi, Yang-Gyu Park, Min-Sang Yun, Jae-Won SeolAbstractAlchemilla vulgaris and Mimosa tenuiflora (Mimosa) have been used to treat cutaneous wounds as a traditional remedy due to their various biological activities. But, there are only a few studies about the effects of these herbs on wound healing. The purpose of this study is to investigate the wound healing effect of the herbal mixture, consisting of A. vulgaris and Mimosa, in mice and to determine the activity of the extract in vitro. In present study, application of an ointment containing the herbal mixture on the dorsal skin wounds of mice showed that the wound healing process was faster than treatment of Fusidic acid. Histological analysis demonstrated the herbal mixture promoted re-epithelialization, collagen synthesis, and especially the regeneration of skin appendages such as hair follicles. Immunohistochemical analysis revealed the herbal mixture improved angiogenesis and the stabilization of blood vessels, as well as accelerated the formation of granulation tissue. In addition, we demonstrated that herbal mixture enhanced the migration of HaCaT, fibroblasts, and HUVECs on a two-dimensional wound, and promoted the proliferation of macrophages and lymphatic vessels. Our results demonstrated that herbal mixture can promote the migration of keratinocytes, fibroblasts, and endothelial cells, and the proliferation of macrop...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 14 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Saritha Valsalam, Agastian Paul, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Abdul-Kareem Mohammed Ghilan, K. Kaviyarasu, Balasubramani Ravindran, Soon Woong Chang, S. ArokiyarajAbstractEco-friendly biosynthesis of nanoparticles from medicinal plants as reducing agent has gained importance due to its potential therapeutic uses. In the present study Silver nanoparticles (AgNPs) were eco-friendly synthesized using the leaf extracts of the medicinal plant Tropaeolum majus. The obtained AgNPs were chara...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
ConclusionsResults suggest that the novel exposure approach may decrease social distress, but not necessarily influence speech fluency. These findings underscore the importance of the assessment and treatment of SAD among adults who stutter and suggest that the integration of care between clinical psychologists and speech-language pathologists may prove beneficial for this population.
Source: Journal of Fluency Disorders - Category: Speech-Language Pathology Source Type: research
Public Health Genomics
Source: Public Health Genomics - Category: Genetics & Stem Cells Source Type: research
Publication date: March 2019Source: Safety Science, Volume 113Author(s): Tao Yang, Peng Chen, Bo Li, Baisheng Nie, Chuanjie Zhu, Qiusheng YeAbstractThe mechanism of gas adsorption and desorption is very important for mine safety. Meanwhile, the gas adsorption or desorption process may lead to temperature or heat variation. In order to reveal this phenomenon, the relationship between gas adsorption (and desorption) and temperature of three different coal samples was experimentally investigated under different temperatures, coal ranks and equilibrium pressures. It’s found that gas adsorption quantity, gas adsorption ra...
Source: Safety Science - Category: Occupational Health Source Type: research
Publication date: March 2019Source: Safety Science, Volume 113Author(s): Markus Brachner, Fredrik Berg Stien, Lars Magnus HvattumAbstractWhile accidents in the petroleum industry are commonly connected to oil spill disasters, helicopter accidents are, in terms of incidence rates, a more grave concern in Norway. In this paper we present a range of mathematical programming models and a workflow that support decision makers in planning an emergency response system. For the models that are difficult to solve directly, we introduce a tailor-made solution method. With respect to the optimization objectives and constraints, we pa...
Source: Safety Science - Category: Occupational Health Source Type: research
Conclusions: Walking speed can be used to accurately screen for frailty in CKD populations. If it is not practical to perform a physical assessment to screen for frailty, the Clinical Frailty Scale is a useful alternative.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research
Hereditary forms of distal renal tubular acidosis (dRTA) are rare and mainly caused by mutations in ATP6V1B1, ATP6V0A4 and SLC4A1. About 20 mutations in SLC4A1 gene have been found that are related to either autosomal dominant (AD) or autosomal recessive dRTA. AD dRTA often manifest as constitutional and can easily be delayed in diagnosis and treatment. A 30-year-old male patient has a history of paroxysmal paralysis for 7 years, presenting with mild hypokalemia, alkalization of urine, normal blood PH value and increased urinary calcium. Patient ’s father has similar presentations but never came to the hospital. We f...
Source: Nephron - Category: Urology & Nephrology Source Type: research
Mutations in theCTNS gene encoding the lysosomal membrane cystine transporter cystinosin are the cause of cystinosis, an autosomal recessive lysosomal storage disease. More than 140CTNS mutations have been reported worldwide. Recent studies have discovered that cystinosin exerts other key cellular functions beyond cystine transport such as regulation of oxidative state, lysosomal dynamics and autophagy. Here, we review the different mutations described in theCTNS gene and the geographical distribution of incidence. In addition, the characteristics of the various mutations in relation to the functions of cystinosin needs to...
Source: Nephron - Category: Urology & Nephrology Source Type: research
Context: Human kidney organoids are complex structures resembling nephron arrays, which can be derived in a variety of ways. Whether all of these differentiation protocols produce qualitatively similar organoid cell types is not yet clear.Subject of Review: A comparative analysis of 2 organoid differentiation protocols is recently reported inCell Stem Cell [Wu et al.: Cell Stem Cell 2018;pii:S1934-5909(18)30491-0], using single cell RNA sequencing (scRNA-seq) as an analytical tool. This demonstrates that the 2 protocols have much in common, and that neither produces kidney cells in a pure or comprehensive manner. Ureteric ...
Source: Nephron - Category: Urology & Nephrology Source Type: research
Publication date: Available online 13 December 2018Source: Actas Urológicas Españolas (English Edition)Author(s): A. Alcántara Montero
Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
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