Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons

Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Zhengzhao Li, Guang Zeng, Xiaowen Zheng, Wenbo Wang, Yun Ling, Huamin Tang, Jianfeng ZhangAbstractTraumatic brain injury (TBI) refers to external force-induced brain damage, characterized with necrosis and cell loss in cerebral cortex. Interestingly, a plant-extract named formononetin (FN) is found to possess promising pharmacological activities, including cellular neuroprotection. Thus, we propose that FN may exert biological protection against TBI and discuss the underlying mechanism. In the current study, a rat TBI model was established via Feeney's classical method, followed by different concentrations of FN treatment. Nissl-special and DAPI-labeled stains were utilized to assess the proliferation of cortical neurons nearing lesioned tissue. The contents of interleukin-6 (IL6), tumor necrosis factor (TNF-α), and interleukin-10 (IL10) in serum and the cortical neurons were determined by ELISA. Further, intracephalic IL10 expression levels were detected through immunoassay and RT-PCR. Interestingly, the results exhibited within the FN-treated TBI rat model indicated elevated cortical proliferation. The levels of IL10 in serum and the cortical neurons were increased following FN treatments, while TNF-α and IL6 levels in the blood were decreased. In addition, both mRNA and protein expression levels of IL10 in the FN-treated TBI rat model were up-regulated in a dose-depende...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

Related Links:

Authors: Shibata N, Matsumoto K, Kitamura S, Sakashita A, Kizawa Y, Hirata KI Abstract A 67-year-old woman was admitted to our hospital due to an acute onset of consciousness disturbance, aphasia and left hemiplegia. Computed tomography revealed multiple systemic infarctions, including brain, kidney and spleen. Transesophageal echocardiography revealed vegetations attached to the mitral valve leaflets, which was suspected to be the embolic source. Repeated blood cultures were negative, and advanced lung cancer was incidentally revealed by computed tomography. She was then diagnosed with nonbacterial thrombotic endo...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
▒ E Abstract Kaymak-Cihan M, Erdi┼č E, Bozkurt S, Ünver-Kor─čal─▒ E. Pediatric primary anaplastic ganglioglioma with malignant neuronal component. Turk J Pediatr 2018; 60: 102-106. Gangliogliomas (GGs) represent approximately 0.4%-1.0% of all brain tumors. Anaplastic gangliogliomas (AGGs) form 5-10% of all GGs. They are a mixed neuronal-glial tumor of central nervous system and composed by two cell lines; neuronal (ganglionic) and glial cells. Anaplastic component of AGGs is usually glial cells. Malignant neuronal component is a rare condition. Here we report an 8-year-old male patient who was diagnosed with ...
Source: The Turkish Journal of Pediatrics - Category: Pediatrics Authors: Tags: Turk J Pediatr Source Type: research
This study also provides further functional and biochemical evidence of the mechanisms of CICI. Using novel object recognition (NOR), we demonstrated the Dox administration resulted in memory deficits, an effect that was rescued by MESNA. Using hydrogen magnetic resonance imaging spectroscopy (H1-MRS) techniques, we demonstrated that Dox administration led to a dramatic decrease in choline-containing compounds assessed by (Cho)/creatine ratios in the hippocampus in mice. To better elucidate a potential mechanism for this MRS observation, we tested the activities of the phospholipase enzymes known to act on phosphatidylchol...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conditions:   Glioblastoma;   Glioblastoma Multiforme;   GBM;   Brain Cancer Intervention:   Procedure: Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB) Sponsor:   Northwell Health Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Brain Diseases;   Brain Cancer Interventions:   Device: Wiersma Head Stabilizer;   Device: AlignRT system Sponsor:   University of Chicago Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Glioblastoma;   Glioblastoma Multiforme;   GBM;   Brain Cancer Intervention:   Procedure: Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB) Sponsor:   Northwell Health Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Brain Diseases;   Brain Cancer Interventions:   Device: Wiersma Head Stabilizer;   Device: AlignRT system Sponsor:   University of Chicago Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In the next 5-7 years, the bioprinting market is estimated to expand by 15.7 percent, and it is anticipated to grow over $4.70 billion by 2025, according to the latest study of BIS Research. While the growth statistics indicate a turbulent landscape, it is worth familiarizing with the main players. Here, we collected the best bioprinting companies currently on the market. The future of bioprinting: tissues not organs The idea of lab-grown organs might mean the end of testing drugs on animals or humans, the solution for organ shortages and an ending of the desperate state of organ donations worldwide. If the creators of the...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: 3D Printing in Medicine Biotechnology Business Future of Medicine 3d printed bioprinting company Healthcare Innovation market regenerative skin Source Type: blogs
Melanoma is a type of cancer that affects the skin cells. If it has progressed to stage 4, this means it has spread beyond the skin to other organs, such as the liver, brain, or lungs. In this article, learn about survival rates, traditional treatments, and new treatment methods, such as targeted therapy drugs.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news
(Georgetown University Medical Center) A valuable cache of brain cancer biomedical data, one of only two such large collections in the country, has been made freely available worldwide by researchers at Georgetown Lombardi Comprehensive Cancer Center.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
More News: Brain | Brain Cancers | Drugs & Pharmacology | Neurology | Study