Evaluation of the effect of andrographolide and methotrexate combined therapy in complete Freundʼs adjuvant induced arthritis with reduced hepatotoxicity

ConclusionsA combined therapy of AD and methotrexate significantly alleviated MTX-induced hepatocellular injury and strengthened the anti-arthritic effect. Further clinical studies should be done to further verify the possibility of combined its clinical usage.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

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We examined the osteoarthritic distal femora of an individual from Ancient North China, ca. 475-221 BCE. The standard signs of osteoarthritis, marginal lipping and extensive eburnation, were observed in the patellofemoral compartment of the knee joint. In addition however were bilateral pressure-caused fossae on the extra-articular anterior surfaces of the distal femora 10 mm proximal to the large osteophytes at the apex of the patellar surfaces. Anatomy and possible pathogenesis of knee arthritis are explored in order to come to a tentative aetiology of the extra-articular lesions. These lesions are suggested to be...
Source: International Journal of Paleopathology - Category: Pathology Source Type: research
Publication date: 22–28 September 2018Source: The Lancet, Volume 392, Issue 10152Author(s): Elshad Hasanov, Elmira Vaziri Fard, Abin Puravath, Jason S Johnston, Shareez Peerbhai, Cristhiam M Rojas-Hernandez
Source: The Lancet - Category: General Medicine Source Type: research
Roche announced today that the European Committee for Medicinal Products for Human Use (CHMP) has adopted a positive opinion for the subcutaneous (SC) formulation of RoActemra ® (tocilizumab) for the treatment of active systemic juvenile idiopathic arthritis (sJIA) in patients one year of age and older.
Source: Roche Investor Update - Category: Pharmaceuticals Source Type: news
Authors: Wang HX, Kang X, Chu S, Li H, Li X, Yin X, Qiu YR, Lai W Abstract Regulatory T cells (Tregs) serve an important role in the pathogenesis of rheumatoid arthritis (RA) by regulating autoimmunity and inflammation. Humans and mice contain inducible T-cell costimulator-positive (ICOS+) Tregs, although their role in RA is unclear. A total of 33 patients with RA and 17 normal control (NC) subjects were examined. The proportion of ICOS+ Tregs in the peripheral blood and intracellular cytokine levels in these cells were assessed using flow cytometry. The percentage of ICOS+ Tregs increased in the cohort of patients...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Jin Y, Chen X, Gao Z, Liu K, Hou Y, Zheng J Abstract The aim of the present study was to investigate the expression levels of interleukin-15 (IL-15) and interleukin-17 (IL-17) in synovial fluid of rheumatoid arthritis (RA) animal model, and to investigate their correlations with RA. A total of 100 Wistar rats were selected, among which 60 rats were used to establish the collagen II-induced arthritis (CIA) model as the model observation group, and the remaining 40 rats were used as blank control group. The levels of IL-15 and IL-17 in synovial fluid were detected via enzyme-linked immunosorbent assay (ELISA...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Radi G, Campanati A, Diotallevi F, Molinelli E, Offidani A Abstract BACKGROUND: Apremilast is a "small molecule", an oral phosphodiesterase 4 inhibitor indicated for the twice- daily treatment of adults with psoriasis (PsO) and psoriatic arthritis (PsA). Data concerning clinical experience in real world setting with Apremilast for psoriasis are still exiguous, and aim of this report is to provide our experience in the use of Apremilast in out-patient setting. METHODS: Ten caucasian individuals (6 male, 4 females; mean age 69,3; range 53-81 years) affected by moderate to severe plaque psoriasi...
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
We present the results of a long term observational study of RA-1 (Ayurvedic drug) used in the treatment of rheumatoid arthritis (RA).ObjectiveThe objective was to study safety of long term use of RA-1 for treatment of rheumatoid arthritis (RA).Materials and methodsOn completion of a 16 week randomized controlled study, 165 consenting volunteer patients were enrolled into a three year open label phase (OLP) study. Patients were symptomatic with persistent active disease and naïve for disease modifying anti-rheumatic drugs (DMARD). 57 patients were on fixed low dose prednisone. Patients were examined every 10–14 ...
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
ConclusionsUsing an evidence-based approach followed by expert consensus, this initiative should improve the assessment and optimization of adherence in chronic inflammatory rheumatic disorders.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Publication date: Available online 19 September 2018Source: Joint Bone SpineAuthor(s): Minh Vu Chuong Nguyen, Annie Adrait, Athan Baillet, Candice Trocmé, Jacques-Eric Gottenberg, Philippe Gaudin
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Publication date: Available online 19 September 2018Source: Joint Bone SpineAuthor(s): Renaud Felten, Florence Scher, Jean Sibilia, François Chasset, Laurent ArnaudABSTRACTThere have been many advances in the diagnosis and therapeutic management of Systemic Lupus Erythematosus (SLE) over the past decades. Following more than eleven centuries of therapeutic uncertainty, the discovery of the therapeutic properties of glucocorticoids is without any doubt one of the most significant advance in the field of autoimmune diseases. The many progresses made by rapidly growing chemical industry of the 19th century chemistry ha...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
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