Evaluation of the effect of andrographolide and methotrexate combined therapy in complete Freundʼs adjuvant induced arthritis with reduced hepatotoxicity

ConclusionsA combined therapy of AD and methotrexate significantly alleviated MTX-induced hepatocellular injury and strengthened the anti-arthritic effect. Further clinical studies should be done to further verify the possibility of combined its clinical usage.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

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Introduction: Sacro-iliac joint septic arthritis is an infrequent disease entity representing 1 –2% of septic arthritis. Here, we report a case of a 29-year-old female with sacro-iliitis secondary to MRSA bacteraemia that followed an uneventful C-Section.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Movies Case Reports 2 – PPH, Puerperium and Neurology Source Type: research
Introduction: There is a need for effective and safe treatment during pregnancy in women with chronic inflammatory diseases (rheumatoid arthritis/axial spondyloarthritis/psoriatic arthritis/Crohn's disease). Adequate disease control is crucial to reduce the risk of adverse pregnancy outcomes. Anti-TNFs are effective therapies, but because most cross the placenta they are often stopped during pregnancy. Certolizumab pegol (CZP), due to its Fc-free molecular structure, is not expected to undergo placental transfer compared to other anti-TNFs.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Basic Science 6 – Teratology genetics and outcomes Source Type: research
This study adds additional information to the growing body of literature about adults with RA who practice yoga.
Source: Holistic Nursing Practice - Category: Nursing Tags: FEATURES Source Type: research
Katina Schinnerling, Carlos Rosas, Lilian Soto, Ranjeny Thomas, Juan Carlos Aguill ón
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This study evaluated the arthritogenic effect of lipopolysaccharide (LPS) in a mouse model of periodontal disease. Periodontitis was induced in wild-type CD1 mice by nine LPS injections (10 or 50  ng) into the maxillary mucosa. Untreated mice or injected with LPS at the tail were used as controls. Two weeks after final inoculation, mice were sacrificed to collect blood, maxilla, and paw samples. Development and progression of periodontitis and arthritis were monitored using clinical assessm ent, micro-computed tomography (micro-CT), ultrasound (US), and histological analysis. CXCL1, IL-1β, IL-6, TNF-α, and ...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
(MedPage Today) -- Trial data indicates it helps with some symptoms, for others not so much
Source: MedPage Today Dermatology - Category: Dermatology Source Type: news
ConclusionsIntraarticular injections of 13 nm or 50 nm AuNPs showed an antioxidant action significantly raising catalase activity without causing negative effects on hematological indices. Prophylactic treatment with 50 nm more than with 13 nm AuNPs suppressed joint swelling, synovial angiogenesis and cartilage erosion in the initial stage of arthritis.
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
Conditions:   Rheumatoid Arthritis;   Inflammatory Arthritis Intervention:   Sponsors:   Arthritis Northwest PLLC;   Bristol-Myers Squibb;   Discus Analytics LLC Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The cell phone blares out reveille. Your eyes open reluctantly and you realize it’s morning, having only gone to bed four hours earlier because of a late-night party. You creak out of bed to ready yourself for work, arthritic joints hurting much more than usual. A painful day lies ahead even after taking ibuprofen. Does this sound familiar? If it does, you are not alone. Nearly 70% of Americans report getting insufficient sleep on a regular basis, and approximately 20% of Americans suffer from chronic pain. Recently, the intersection between these two conditions has become more apparent. The association between sleep...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Fatigue Pain Management Sleep Source Type: blogs
A GAME-CHANGING daily pill to treat the most common form of arthritis could soon be available for millions of Britons. Scientists are testing the drug, known as APPA, on humans after finding that it significantly relieves osteoarthritis pain in animals.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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