Study on the efficacy and mechanism of triptolide on treating TNF transgenic mice with rheumatoid arthritis

Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Shengli Wang, Shuguang Zuo, Zhigang Liu, Xinying Ji, Zhenqiang Yao, Xinchun WangAbstractObjectiveTo discuss the curative effect and security of triptolide (TPL) on TNF transgenic (TNF-Tg) mice with rheumatoid arthritis (RA), and to explore the mechanism primarily.Method40 TNF-Tg RA mice were randomlydivided into five groups averagely: the control group, low-dose group (3.3 μg/kg/d TPL), middle-dose group (10 μg/kg/d TPL), high-dose group (33 μg/kg/d TPL) and MTX group (0.1 mg/kg/d MTX). Mice were administrated five days a week for six weeks. The arthritis deformation index, arthritis detumescencepercentage and the level of inflammatory factor in each group were recorded during theadministration. After administration, body weight, liver and renal function indexes, the apoptosis rates of osteoclast precursors (OCP), T and B lymphocytes in the peripheral blood and the number of osteoclast (OC) were detected and compared. μCT scanning and HE staining methods were taken to observethebone histomorphometry and bony erosion.ResultAfter administration, the arthritis deformation indexes were lower and arthritis detumescence percentageswere higher in TPL groups thanthe control group (P 
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

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ConclusionCT offers a combined opportunistic screening for osteoporosis by assessing both vertebral fractures and bone density on routine CT-scans. This approach may be particularly interesting for RA patients with a high osteoporosis risk.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
We report a rare case of cervical lymphadenitis and pulmonary disease caused byMycobacterium paraffinicum. With over 150 species, non ‐tuberculous mycobacteria are increasingly recognized to be important human pathogens that pose diagnostic and management challenges. We report a rare case of cervical lymphadenitis and pulmonary disease caused byMycobacterium paraffinicum in a 64 ‐year‐old man who presented with three‐month history of increasing right‐sided painless neck lump. His medical history included rheumatoid arthritis, which was managed with leflunomide and methotrexate. Computed tomography scans of his ne...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
AbstractOver the last decades, ultrasound (US) has undergone a dramatic evolution in the field of inflammatory joint diseases. Rheumatoid arthritis (RA) is probably the pathology that has most benefited from this development, both in terms of early diagnosis and monitoring of disease activity. The RA-induced morpho-structural changes can be effectively detected and measured by US, and US findings represent an additional advantage over clinical and laboratory evaluation, showing the face of the disease (i.e., proliferative synovitis) and revealing its aggressive behavior (i.e., presence of bone erosions not detectable by co...
Source: La Radiologia Medica - Category: Radiology Source Type: research
ConclusionOur findings indicate that T cells that recognize citrullinated aggrecan are present in patients with RA and correlate with antibodies that target this same antigen. Consequently, aggrecan ‐specific T cells and antibodies are potentially relevant markers that could be used to monitor patients with RA or at‐risk subjects.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
CONCLUSION: As no difference in outcome was found between the compared doses, the lower 20 mg THA dose should be preferred in IAGC treatment for knee synovitis in chronic polyarthritis. This may also reduce pharmaceutical costs and metabolic side effects. EudraCT number: 2014-000993-20, Clinical identifier: NCT02437461. PMID: 30843453 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Tags: Scand J Rheumatol Source Type: research
CONCLUSIONS: Patients with JIA, PsA, RA, and AxSpA share similar patterns of healthcare resource utilization, with substantial comorbidity costs and a minority being high utilizers. Innovations in meeting these patients' needs are warranted. PMID: 30836033 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Tags: Scand J Rheumatol Source Type: research
ConclusionSubclinical myocardial inflammation is frequent in patients with RA, is associated with RA disease activity, and may decrease with RA therapy. Future longitudinal studies will be required to assess whether reduction in myocardial inflammation will reduce heart failure risk in RA.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
Journaling can transform not only my physical health, but also emotional and spiritual health. I didn’t always love my body. In fact, for years, I hardly thought about it at all. My body was a machine that I worked relentlessly and neglected constantly. It was simply a tool that my brain used to get where it needed to go. I paid no mind to aching muscles, searing headaches and other signs of stress and exhaustion. I ignored my body’s needs until a major health challenge forced me to stop and recognize the obvious: my body isn’t a machine at all. It’s an integral part of me that requires love, care a...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Exercise & Fitness Health-related Mindfulness Personal Publishers Self-Esteem Self-Help Spirituality & Health body Body Image body love Emotional Health habits Journaling journaling prompts Physical Health Spiritual Health Source Type: blogs
This study assessed the correlation of positron emission tomography (PET) ‐derived parameters in 68 joints with disease activity and compared the reliability of joint counts between PET/computed tomography (CT) and clinical assessment in rheumatoid arthritis (RA).MethodsWe enrolled 91 patients with active RA who underwent fluorine ‐18‐fluorodeoxyglucose PET/CT and disease activity evaluation at the same time. This two‐step study involved a development (n=69) and validation (n=22) group. PET‐derived parameters were compared with clinical disease activity. Subsequently, we developed a disease activity score (DAS) u...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
Cochrane is made up of  13,000 members and over 50,000 supporters come from more than 130 countries, worldwide. Our volunteers and contributors are researchers, health professionals, patients, carers, people passionate about improving health outcomes for everyone, everywhere.Cochrane is an incredible community of people who all play their part in improving health and healthcare globally. We believe that by putting trusted evidence at the heart of health decisions we can achieve a world of improved health for all.  Many  of our contributors are young people working with Cochrane ...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
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