Study on the efficacy and mechanism of triptolide on treating TNF transgenic mice with rheumatoid arthritis

Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Shengli Wang, Shuguang Zuo, Zhigang Liu, Xinying Ji, Zhenqiang Yao, Xinchun WangAbstractObjectiveTo discuss the curative effect and security of triptolide (TPL) on TNF transgenic (TNF-Tg) mice with rheumatoid arthritis (RA), and to explore the mechanism primarily.Method40 TNF-Tg RA mice were randomlydivided into five groups averagely: the control group, low-dose group (3.3 μg/kg/d TPL), middle-dose group (10 μg/kg/d TPL), high-dose group (33 μg/kg/d TPL) and MTX group (0.1 mg/kg/d MTX). Mice were administrated five days a week for six weeks. The arthritis deformation index, arthritis detumescencepercentage and the level of inflammatory factor in each group were recorded during theadministration. After administration, body weight, liver and renal function indexes, the apoptosis rates of osteoclast precursors (OCP), T and B lymphocytes in the peripheral blood and the number of osteoclast (OC) were detected and compared. μCT scanning and HE staining methods were taken to observethebone histomorphometry and bony erosion.ResultAfter administration, the arthritis deformation indexes were lower and arthritis detumescence percentageswere higher in TPL groups thanthe control group (P 
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research

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ConclusionCAA-ri should be considered among the differential diagnoses for causes of unprovoked seizure onset in elderly individuals, when associated with petechial hemorrhages on T2*-GRE and SWI sequences on MRI.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: July 2018Source: Biocatalysis and Agricultural Biotechnology, Volume 15Author(s): S. Srividya, G. Sridevi, B. Santhosh Kumar, T.P. SastryAbstractAllogenous grafts with excellent biocompatibility and immuno-compatibility play a major role in most of the biomedical applications. In this regard, the present study focuses on fabricating a novel bone graft material containing biopolymers and phytochemicals which can replace the use of autogenous graft with high biocompatibility and osteogenecity. Based on this, a bone graft material was synthesized using biphasic calcium phosphate (BCP), casein (CA), hen egg y...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
CONCLUSION: Early changes in MBDA score were associated with clinical remission based on DAS28-CRP at 6 months. In anti-CCP-positive patients, a non-high baseline MBDA score (≤ 44) had a clinical value by predicting very low risk of radiographic progression at 12 months. PMID: 29985080 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Tags: Scand J Rheumatol Source Type: research
Abstract OBJECTIVE: To discuss the curative effect and security of triptolide (TPL) on TNF transgenic (TNF-Tg) mice with rheumatoid arthritis (RA), and to explore the mechanism primarily. METHOD: 40 TNF-Tg RA mice were randomlydivided into five groups averagely: the control group, low-dose group (3.3 μg/kg/d TPL), middle-dose group (10 μg/kg/d TPL), high-dose group (33 μg/kg/d TPL) and MTX group (0.1 mg/kg/d MTX). Mice were administrated five days a week for six weeks. The arthritis deformation index, arthritis detumescencepercentage and the level of inflammatory factor in each group were rec...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
ConclusionCAA-ri should be considered among the differential diagnoses for causes of unprovoked seizure onset in elderly individuals, when associated with petechial hemorrhages on T2*-GRE and SWI sequences on MRI.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: July 2018Source: Biocatalysis and Agricultural Biotechnology, Volume 15Author(s): S. Srividya, G. Sridevi, B. Santhosh Kumar, T.P. SastryAbstractAllogenous grafts with excellent biocompatibility and immuno-compatibility play a major role in most of the biomedical applications. In this regard, the present study focuses on fabricating a novel bone graft material containing biopolymers and phytochemicals which can replace the use of autogenous graft with high biocompatibility and osteogenecity. Based on this, a bone graft material was synthesized using biphasic calcium phosphate (BCP), casein (CA), hen egg y...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Abstract OBJECTIVES: The aim of the study was to determine the prevalence of widespread pain (WP) in women with early rheumatoid arthritis (RA) and to compare physical function, activity limitations, health-related quality of life, mental distress, and disease activity between women with WP and non-widespread pain (NWP). METHOD: This cross-sectional study included 102 women with early RA. Participants were provided with self-reported questionnaires quantifying activity limitations, physical activity, pain intensity, health-related quality of life, and fatigue. Hand-grip force, muscle function test of the lowe...
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Tags: Scand J Rheumatol Source Type: research
Abstract OBJECTIVE: To prospectively investigate the effect of tocilizumab (TCZ) on the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), as a predictor of congestive heart failure (CHF) in patients with active rheumatoid arthritis (RA). METHOD: Seventy patients with RA (median age 59 years, 86% female) free of cardiovascular disease were treated with TCZ and followed for 24 weeks. The NT-proBNP levels were measured at baseline and week 24. Thirty healthy controls were included for comparison of normal NT-proBNP levels with those of RA patients. RESULTS: The NT-proBNP level was si...
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Tags: Scand J Rheumatol Source Type: research
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impa...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 24 May 2018 Source:Biocatalysis and Agricultural Biotechnology Author(s): S. Srividya, G. Sridevi, B. Santhosh Kumar, T.P. Sastry Allogenous grafts with excellent biocompatibility and immuno-compatibility play a major role in most of the biomedical applications. In this regard, the present study focuses on fabricating a novel bone graft material containing biopolymers and phytochemicals which can replace the use of autogenous graft with high biocompatibility and osteogenecity. Based on this, a bone graft material was synthesized using biphasic calcium phosphate (BCP), casein (CA), hen eg...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
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