Efficacy of Autologous Platelet Concentrates as Adjuvant Therapy to Surgical Excision in the Treatment of Keloid Scars Refractory to Conventional Treatments: A Pilot Prospective Study

Background After conventional treatments, keloid scars show varying degrees of recurrence. The aim of this study was to assess the efficacy and safety of platelet-rich plasma in the treatment of postoperative keloid scars refractory to conventional treatments. Methods This pilot prospective study was conducted in 17 patients with keloid scars who did not respond to 4 injections of cortisone or radiotherapy after extralesional resection of keloid. Platelet-rich plasma was injected intraoperatively and then 3 times with a 1-month interval. The primary end point was the complete remission of keloid scars 2 years posttreatment. Scar pruritus severity was scored before and after treatment. The study protocol was approved by the ethics committee and authorized by the French National Agency. This trial was registered at ClinicalTrials.gov, identifier NCT02922972. Results Nine keloid scars (53%) were completely resolved at 2 years, and 5 (29%) completely relapsed after treatment. Pruritus severity score was significantly lower at 2 years compared with baseline (1.33 ± 0.97 before treatment and 0.40 ± 0.63 at 2 years, P
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research

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Recent researches have indicated that S100A4 participates in tissue fibrosis, whereas calcimycin inhibits this process as a novel S100A4 transcription inhibitor. However, the relationship and mechanisms between calcimycin and S100A4 in keloid fibroblasts (KFs) remain unknown. The present research was aimed to evaluate the effect of calcimycin on S100A4 expression and pathogenesis in KFs. Keloid fibroblasts were cultured and exposed to different concentrations of calcimycin in the absence or presence of transforming growth factor β1 (TGF-β1). The results showed that the expression of S100A4 was significantly incre...
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research
ConclusionOur results did not support verapamil’s capability in treatment of keloid nor hypertrophic scars.
Source: Burns - Category: Dermatology Source Type: research
Centella asiatica (Centellicum®) facilitates the regular healing of surgical scars in subjects at high risk of keloids. Minerva Chir. 2018 Apr;73(2):151-156 Authors: Cotellese R, Hu S, Belcaro G, Ledda A, Feragalli B, Dugall M, Hosoi M, Ippolito E Abstract BACKGROUND: Formation of scars after surgical incisions requires the proper appositions of elements contributing to the scarring process. The structural rebuilding of damaged tissues is essential in producing a linear scar. The excess of blood, foreign particles, exuberant sutures, necrotic tissue, possible infective agents, as well as the ongoin...
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
Ear keloid is a challenging problem [1]. Despite the availability of different treatment options still there is a significant number of treatment failures and variable final outcome [1 –3]. Surgical excision has found a good place among its treatment options, but alone it results in 45–100% recurrence rates [2].
Source: Burns : Journal of the International Society for Burn Injuries - Category: Cosmetic Surgery Authors: Source Type: research
Publication date: Available online 28 October 2017 Source:Burns Author(s): Peter D. Drummond, Linda F. Dawson, Fiona M. Wood, Mark W. Fear Stimulation of α1-adrenoceptors evokes inflammatory cytokine production, boosts neurogenic inflammation and pain, and influences cellular migration and proliferation. Hence, these receptors may play a role both in normal and abnormal wound healing. To investigate this, the distribution of α1-adrenoceptors in skin biopsies of burn scars (N=17), keloid scars (N=12) and unscarred skin (N=17) was assessed using immunohistochemistry. Staining intensity was greater on vascular sm...
Source: Burns - Category: Dermatology Source Type: research
Abstract: Epithelial-mesenchymal transition (EMT) plays a critical role in fibrotic keloid formation, which is characterized by excessive collagen and extracellular matrix synthesis and deposition. Growing evidence suggests that the serine/threonine kinase homeodomain-interacting protein kinase 2 (HIPK2) acts upstream of several major fibrosis signaling pathways; however, the role of HIPK2 in the keloid fibrogenesis remains unknown. In the current study, we investigated the roles of HIPK2 in the pathogenesis of keloids. Primary normal skin and keloid keratinocytes were cultured and pretreated with transforming growth facto...
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research
Our extensive clinical experience with burn scar reconstruction and our studies on the mechanisms underlying burn scar development have led us to realize that achieving full release of post-burn contractures is essential for obtaining good functional and aesthetic outcomes. In particular, we have accumulated considerable evidence suggesting that common post-burn sequelae that cause contractures such as hypertrophic scars and keloids are caused by mechanical tension on the edges of the wound/scar.
Source: Burns : Journal of the International Society for Burn Injuries - Category: Cosmetic Surgery Authors: Source Type: research
A reciprocal relationship between α1-adrenoceptors (α1-AR) and cytokines may shape inflammation and wound healing. Activation of particular α1-AR subtypes boosts the migration and proliferation of fibroblasts in wounds [1–4], and triggers an increase in pro-inflammatory cytokine production in a range of cells [5–8]. Conversel y, in human THP-1 monocytes, interleukin-1β and tumour necrosis factor-α induce the expression of messenger RNA for the α1A-AR [9].
Source: Burns : Journal of the International Society for Burn Injuries - Category: Cosmetic Surgery Authors: Source Type: research
Our extensive clinical experience with burn scar reconstruction and our studies on the mechanisms underlying burn scar development have led us to realize that achieving full release of post-burn contractures is essential for obtaining good functional and aesthetic outcomes. In particular, we have accumulated considerable evidence suggesting that common post-burn sequelae that cause contractures such as hypertrophic scars and keloids are caused by mechanical tension on the edges of the wound/scar.
Source: Burns : Journal of the International Society for Burn Injuries - Category: Cosmetic Surgery Authors: Source Type: research
A reciprocal relationship between α1-adrenoceptors (α1-AR) and cytokines may shape inflammation and wound healing. Activation of particular α1-AR subtypes boosts the migration and proliferation of fibroblasts in wounds [1–4], and triggers an increase in pro-inflammatory cytokine production in a range of cells [5–8]. Conversel y, in human THP-1 monocytes, interleukin-1β and tumour necrosis factor-α induce the expression of messenger RNA for the α1A-AR [9].
Source: Burns : Journal of the International Society for Burn Injuries - Category: Cosmetic Surgery Authors: Source Type: research
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