Efficacy of Autologous Platelet Concentrates as Adjuvant Therapy to Surgical Excision in the Treatment of Keloid Scars Refractory to Conventional Treatments: A Pilot Prospective Study

Background After conventional treatments, keloid scars show varying degrees of recurrence. The aim of this study was to assess the efficacy and safety of platelet-rich plasma in the treatment of postoperative keloid scars refractory to conventional treatments. Methods This pilot prospective study was conducted in 17 patients with keloid scars who did not respond to 4 injections of cortisone or radiotherapy after extralesional resection of keloid. Platelet-rich plasma was injected intraoperatively and then 3 times with a 1-month interval. The primary end point was the complete remission of keloid scars 2 years posttreatment. Scar pruritus severity was scored before and after treatment. The study protocol was approved by the ethics committee and authorized by the French National Agency. This trial was registered at ClinicalTrials.gov, identifier NCT02922972. Results Nine keloid scars (53%) were completely resolved at 2 years, and 5 (29%) completely relapsed after treatment. Pruritus severity score was significantly lower at 2 years compared with baseline (1.33 ± 0.97 before treatment and 0.40 ± 0.63 at 2 years, P
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research

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AbstractKeloids can be recalcitrant, and a well-planned treatment strategy is essential. Multiple ear piercings have recently become popular, particularly among younger age groups. Management of keloids that develop after piercing of the ear cartilage may be particularly problematic. Helical rim keloids are difficult to excise because of the complex, three-dimensional, cartilaginous structure of the helix and its thin and tightly adherent covering layer of skin. The chondrocutaneous advancement flap introduced by Antia and Buch may be a useful reconstructive option for a helical rim keloid after marginal loss of a segment ...
Source: Aesthetic Plastic Surgery - Category: Cosmetic Surgery Source Type: research
Conclusion: Topical administration of oxandrolone using hyaluronic acid as a biomaterial led to better healing and prevented hypertrophic scar formation.
Source: Plastic and Reconstructive Surgery - Category: Cosmetic Surgery Tags: Experimental Source Type: research
Publication date: Available online 14 January 2019Source: BurnsAuthor(s): Farrukh Aslam Khalid, Muhammad Younas Mehrose, Muhammad Saleem, Muhammad Amin, Abdul Malik Mujahid, Saif Ur Rehman, Sania AhmAd, Moazzam Nazeer Tarar
Source: Burns - Category: Dermatology Source Type: research
Burn scars are usually characterised by a combination of hypertrophic and keloid scars that are often very challenging to treat. They are a consequence of abnormal collagen deposition by fibroblasts exhibiting a hypersensitive response to growth factors.1 These scars can have a profound effect on patients both functionally and psychologically due to their poor cosmesis and debilitating symptoms.2 Currently there is no reliable or satisfactory treatment available to address the long-term sequelae of burns, however, more recently the use of laser-based treatments has been attributed to a paradigm shift in the management of burn scarring.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Tags: Correspondence and Communications Source Type: research
Burn scars are usually characterised by a combination of hypertrophic and keloid scars that are often very challenging to treat. They are a consequence of abnormal collagen deposition by fibroblasts exhibiting a hypersensitive response to growth factors.1 These scars can have a profound effect on patients both functionally and psychologically due to their poor cosmesis and debilitating symptoms.2 Currently there is no reliable or satisfactory treatment available to address the long-term sequelae of burns, however, more recently the use of laser-based treatments has been attributed to a paradigm shift in the management of burn scarring.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Tags: Correspondence and Communications Source Type: research
The aim of this study was to compare the quality of postburn facial scars before and after injection of unfiltered nanofat. The study was performed in the Plastic Surgery Department of Mayo Hospital, Lahore, Pakistan, from January 2015 to December 2016. Forty-eight patients with postburn facial scars were included; age range was 4 to 32 years with Fitzpatrick skin types between 3 and 4. Patients with hypertrophic scars, contractures, or keloids were excluded. Scars were assessed by a senior plastic surgeon and the patient on the POSAS (Patient Observer Scar Assessment Scale). Fat was harvested from the abdomen and/or thigh...
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research
The objective is to evaluate the impact of keloid on body image.Methods61 patients with keloid in socially exposed regions of the body were included. The participants were submitted to clinical evaluation, composed of anamnesis and physical examination, and answered two questionnaires: the Body Dysmorphic Symptoms Scale (BDSS) questionnaire and the Rosenberg Self-Esteem Scale – Unifesp/EPM.ResultsForty percent of the patients had negative aspects of body image (BDSS score ≥ 6). The scores of these patients on the Rosenberg Scale reached an average of 10.5 (p 
Source: Burns - Category: Dermatology Source Type: research
The aim of this study was to assess gene expression of neurotrophins and their receptors in keloids. Skin samples of normal skin and keloids were obtained from patients in the control (n = 12) and keloid (n = 12) groups, respectively. Ribonucleic acid was extracted from the skin specimens, purified, evaluated by spectrophotometry, and used to synthesize complementary DNA. Real-time quantitative polymerase chain reaction analysis of 84 human neurotrophin genes and their receptors was performed. Twelve genes, including heat shock 27-kDa protein 1, gastrin-releasing peptide receptor, corticotropin-releasing hormone receptor 2...
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to evaluate the efficacy of early intervention in wound healing on scar formation across multiple scar types and progressions. The types of scars consist of hypertrophic, atrophic, keloid, and contracture scars. The sources of scarring include inflammatory diseases (e.g., acne), surgery, burn, and trauma.Recent FindingsMinimal published research has been done regarding laser treatment in wound healing. Some studies have found promise in minor treatment of surgical wounds but few have sufficient clinical relevance. Recently, further studies have been conducted including...
Source: Current Dermatology Reports - Category: Dermatology Source Type: research
Conclusion: We indicate in the first time that it may be mediated by Sirt1 for resveratrol activating the Shh signaling to enhance viability of NIH3T3 cells, and Sirt1 may be a regulator for upstream of the Shh signaling pathway.This study provides a basis for further investigating effects and mechanism of resveratrol during the formation of fibrous scar after brain or spinal cord injury.Cell Physiol Biochem 2018;50:1346 –1360
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
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