Efficacy of Autologous Platelet Concentrates as Adjuvant Therapy to Surgical Excision in the Treatment of Keloid Scars Refractory to Conventional Treatments: A Pilot Prospective Study

Background After conventional treatments, keloid scars show varying degrees of recurrence. The aim of this study was to assess the efficacy and safety of platelet-rich plasma in the treatment of postoperative keloid scars refractory to conventional treatments. Methods This pilot prospective study was conducted in 17 patients with keloid scars who did not respond to 4 injections of cortisone or radiotherapy after extralesional resection of keloid. Platelet-rich plasma was injected intraoperatively and then 3 times with a 1-month interval. The primary end point was the complete remission of keloid scars 2 years posttreatment. Scar pruritus severity was scored before and after treatment. The study protocol was approved by the ethics committee and authorized by the French National Agency. This trial was registered at ClinicalTrials.gov, identifier NCT02922972. Results Nine keloid scars (53%) were completely resolved at 2 years, and 5 (29%) completely relapsed after treatment. Pruritus severity score was significantly lower at 2 years compared with baseline (1.33 ± 0.97 before treatment and 0.40 ± 0.63 at 2 years, P
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research

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Skin is a versatile organ endowed with intrinsic functions and physiological interactions with other organs and systems. This organ participates in the interface with the external environment, in social interactions, and interpersonal relationships [1]. Skin wound healing is a vital event for the body to restore the cutaneous integrity. This process consists of several mechanisms and complex signaling cascades, which in harmony and synchronism result in an adequate scar [2]. Perturbations of the balance between synthesis and degradation of collagen, essentially resulting in tissue accumulation, generate fibroproliferative ...
Source: Burns : Journal of the International Society for Burn Injuries - Category: Cosmetic Surgery Authors: Source Type: research
The aim of this study was to assess gene expression of neurotrophins and their receptors in keloids. Skin samples of normal skin and keloids were obtained from patients in the control (n = 12) and keloid (n = 12) groups, respectively. Ribonucleic acid was extracted from the skin specimens, purified, evaluated by spectrophotometry, and used to synthesize complementary DNA. Real-time quantitative polymerase chain reaction analysis of 84 human neurotrophin genes and their receptors was performed. Twelve genes, including heat shock 27-kDa protein 1, gastrin-releasing peptide receptor, corticotropin-releasing hormone receptor 2...
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to evaluate the efficacy of early intervention in wound healing on scar formation across multiple scar types and progressions. The types of scars consist of hypertrophic, atrophic, keloid, and contracture scars. The sources of scarring include inflammatory diseases (e.g., acne), surgery, burn, and trauma.Recent FindingsMinimal published research has been done regarding laser treatment in wound healing. Some studies have found promise in minor treatment of surgical wounds but few have sufficient clinical relevance. Recently, further studies have been conducted including...
Source: Current Dermatology Reports - Category: Dermatology Source Type: research
Conclusion: We indicate in the first time that it may be mediated by Sirt1 for resveratrol activating the Shh signaling to enhance viability of NIH3T3 cells, and Sirt1 may be a regulator for upstream of the Shh signaling pathway.This study provides a basis for further investigating effects and mechanism of resveratrol during the formation of fibrous scar after brain or spinal cord injury.Cell Physiol Biochem 2018;50:1346 –1360
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Conclusion5-FU + TAC is safe, easy to administer and effective treatment for problematic scars and has the lower rate of recurrence on larger follow up.
Source: Burns - Category: Dermatology Source Type: research
ConclusionExcision and intralesional 5-FU/TAC is an effective treatment for keloids on the ears.
Source: Burns - Category: Dermatology Source Type: research
Conclusions The possibility of numerous pedicles makes it possible for PPPFs to offset most areas of wall chest defects. Furthermore, this surgical technique is reliable and reproducible, with lower donor site morbidity than that in the case of muscular flaps, which are classically used in this location.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Review Papers Source Type: research
Both the psychological and psychosocial effects of burn scarring have been researched over the last 20years, particularly in the USA. Indeed, there is a swathe of more recent literature that attempts to address these considerations. Research has shown that patients with hypertrophic and keloid scars suffer impairment to quality of life (QoL) similar to that of patients with chronic skin disease, where QoL is influenced by both experienced and internalised stigmatisation, in addition to physical symptoms and restricted mobility [1].
Source: Burns : Journal of the International Society for Burn Injuries - Category: Cosmetic Surgery Authors: Source Type: research
Recent researches have indicated that S100A4 participates in tissue fibrosis, whereas calcimycin inhibits this process as a novel S100A4 transcription inhibitor. However, the relationship and mechanisms between calcimycin and S100A4 in keloid fibroblasts (KFs) remain unknown. The present research was aimed to evaluate the effect of calcimycin on S100A4 expression and pathogenesis in KFs. Keloid fibroblasts were cultured and exposed to different concentrations of calcimycin in the absence or presence of transforming growth factor β1 (TGF-β1). The results showed that the expression of S100A4 was significantly incre...
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Burn Surgery and Research Source Type: research
ConclusionOur results did not support verapamil’s capability in treatment of keloid nor hypertrophic scars.
Source: Burns - Category: Dermatology Source Type: research
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