Time course of panic disorder and posttraumatic stress disorder onsets

AbstractPurposePosttraumatic stress disorder (PTSD) often co-occurs with panic disorder (PD), with some etiological models positing a causal role of panic reactivity in PTSD onset; however, data addressing the temporal ordering of these conditions are lacking. The aim of this study was to examine the bi-directional associations between PD and PTSD in a nationally representative, epidemiologic sample of trauma-exposed adults.MethodsParticipants were community-dwelling adults (62.6% women;Mage = 48.9, SD 16.3) with lifetime DSM-IV PTSD criterion A trauma exposure drawn from the 2001/2 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) and re-interviewed in 2004/5 (N = 12,467). Cox discrete-time proportional hazards models with time-varying covariates were used to investigate the bi-directional associations between lifetime PD and PTSD, accounting for demographic characteristics, trauma load, and lifetime history of major depression, generalized anxiety dis order, and social anxiety disorder.ResultsPD was significantly associated with subsequent onset of PTSD (HR 1.210, 95%CI  = 1.207–1.214,p 
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research

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In this study, epigenome-wide patterns of methylation were measured in schizophrenia suicide attempters (n = 54) and in schizophrenia non suicide attempters (n = 69) using DNA extracted from white blood cells. Analyses focused on identifying differentially methylated CpG sites and gene regions between attempters and non-attempters. We identified the CpG site cg19647197 within the CCDC53 gene, which is characterized by hypomethylation of WBC in schizophrenia attempters compared to non-attempters. Our results suggest that there is variation in DNA methylation associated with suicide attempt that may offer novel highl...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
ConclusionsThere was no evidence that neither short-term nor long-term exposure to meteorological parameters or air pollen counts were associated with self-reported peripartum depressive symptoms in Uppsala, Sweden.
Source: European Psychiatry - Category: Psychiatry Source Type: research
Abstract The purpose of this review is to summarize current knowledge about the gut microbiota in neuropsychiatric disorders. It is estimated that the human gut is colonized by up to 1018 microorganisms, mostly anaerobic bacteria. The gut microbiome is responsible for multiple functions, e.g. tightness of the intestine barrier, digestion and absorption. The correlation between gut dysbiosis and development of psychiatric, autoimmune and allergic diseases as well as bidirectional communication between brain and gut microflora have been shown. Recent findings suggest that specific bacteria can be involved in the dev...
Source: Acta Neurobiologiae Experimentalis - Category: Neurology Authors: Tags: Acta Neurobiol Exp (Wars) Source Type: research
Publication date: Available online 19 July 2018Source: NeuronAuthor(s): Xiang Nie, Shiho Kitaoka, Kohei Tanaka, Eri Segi-Nishida, Yuki Imoto, Atsubumi Ogawa, Fumitake Nakano, Ayaka Tomohiro, Kazuki Nakayama, Masayuki Taniguchi, Yuko Mimori-Kiyosue, Akira Kakizuka, Shuh Narumiya, Tomoyuki FuruyashikiSummaryRepeated environmental stress has been proposed to induce neural inflammation together with depression and anxiety. Innate immune receptors, such as Toll-like receptors (TLRs), are activated by exogenous or endogenous ligands to evoke inflammation. Here we show that the loss of TLR2 and TLR4 (TLR2/4) abolished repeated so...
Source: Neuron - Category: Neuroscience Source Type: research
This study aimed to evaluate the effects of lorcaserin on body weight, cardiovascular risk factors, and safety in obese patients in Taiwan.MethodsIn this double-blind, randomised controlled trial, 171 obese adults were assigned to receive lorcaserin at a dose of 10 mg, or placebo, twice a day for 24 weeks. Diet and exercise counselling were given to all patients through the treatment period. Primary outcomes were proportion of patients achieving at least 5% and 10% reduction in body weight and mean change in body weight. Safety and tolerability endpoints such as Beck Depression Inventory-II, blood biochemistry, v...
Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
ConclusionAlthough SRMH is a useful tool for estimation of mental health needs of populations, poor SRMH may not have universal meanings across ethnically diverse populations. Ethnic groups differ in how their poor SRMH reflects psychiatric conditions and the role of demographic and socioeconomic factors in explaining such links. These ethnic differences may be a source of measurement bias in cross-ethnic health comparisons.
Source: Journal of Racial and Ethnic Health Disparities - Category: International Medicine & Public Health Source Type: research
Conclusion The SCIP is reliable and valid diagnostic interview, is compatible with experimental psychopathology and personalized psychiatry research, and is in line with the NIMH RDoC framework. The SCIP Instruction Manual is also available for download by visiting http://innovationscns.com/wp-content/uploads/SCIP_Instruction_Manual_2015.pdf. Acknowledgment Dr. Aboraya had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses. References 1.     Stone M. Healing the Mind: A History of Psychiatry from Antiquity to the Present. In: ...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools Current Issue Evaluations Psychiatry Reliability of Diagnoses Review Scales Trial Methodology descriptive psychopathology diagnostic criteria dimensional scores Psychiatric interview SCIP Standard for Clinicians Source Type: research
Conclusion The SCIP is reliable and valid diagnostic interview, is compatible with experimental psychopathology and personalized psychiatry research, and is in line with the NIMH RDoC framework. The SCIP Instruction Manual is also available for download by visiting http://innovationscns.com/wp-content/uploads/SCIP_Instruction_Manual_2015.pdf. Acknowledgment Dr. Aboraya had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses. References 1.     Stone M. Healing the Mind: A History of Psychiatry from Antiquity to the Present. In: ...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools Current Issue Evaluations Psychiatry Reliability of Diagnoses Review Scales Trial Methodology descriptive psychopathology diagnostic criteria dimensional scores Psychiatric interview SCIP Standard for Clinicians Source Type: research
Conclusions Expanding access to mental health services for youth might have a net positive societal value by helping to prevent some of these adverse educational outcomes.
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
Conclusions: The findings highlight the need for gambling treatment services to undertake routine screening and assessment of psychiatric co-morbidity and provide treatment approaches that adequately manage these co-morbid disorders. Further research is required to explore the reasons for the variability observed in the prevalence estimates.
Source: Australian and New Zealand Journal of Psychiatry - Category: Psychiatry Authors: Tags: Review Source Type: research
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