Detection of IgM-rheumatoid factor and anti-citrullinated protein antibodies in healthy horses and their comparison

Publication date: Available online 11 July 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): R. Hoikhman, H. Kudlackova, V. Babak, M. Faldyna, P. JahnAbstractRheumatoid factor (RF) is used in human and veterinary medicine in the form of IgM RF traditionally to support the diagnosis of rheumatoid arthritis (RA). In the latest diagnostic criteria, presence of anti - citrullinated protein antibodies (ACPA) was added to the grading system for the diagnosis of RA in humans. A change which is not integrated or routinely used in veterinary medicine. The criteria changed partly because of RF’s diagnostic shortcomings, which include its increased titer detection in humans with non-rheumatoid diseases, inability to predict the disease and increased titers over the limit in the older population. Clinical signs similar to human RA were reported in horses in a condition known as idiopathic polysynovitis. Similarities in the clinical presentation to RA raised a question to the usability of RF and ACPA in horses. In our study, sixty clinically healthy horses, ranging from 3 days to 30 years of age, were evaluated for their serum levels of IgM RF. 55 of these horses were tested for ACPA, using methods of ELISA measuring Anti - CFG (Anti citrullinated fibrinogen antibody). The results of the study demonstrated the existence of an age-dependent increase in the level of IgM RF up to the age of about 9 years and ACPA’s independence of the horse’s age as well as bo...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research

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Publication date: 22–28 September 2018Source: The Lancet, Volume 392, Issue 10152Author(s): Elshad Hasanov, Elmira Vaziri Fard, Abin Puravath, Jason S Johnston, Shareez Peerbhai, Cristhiam M Rojas-Hernandez
Source: The Lancet - Category: General Medicine Source Type: research
Authors: Wang HX, Kang X, Chu S, Li H, Li X, Yin X, Qiu YR, Lai W Abstract Regulatory T cells (Tregs) serve an important role in the pathogenesis of rheumatoid arthritis (RA) by regulating autoimmunity and inflammation. Humans and mice contain inducible T-cell costimulator-positive (ICOS+) Tregs, although their role in RA is unclear. A total of 33 patients with RA and 17 normal control (NC) subjects were examined. The proportion of ICOS+ Tregs in the peripheral blood and intracellular cytokine levels in these cells were assessed using flow cytometry. The percentage of ICOS+ Tregs increased in the cohort of patients...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Jin Y, Chen X, Gao Z, Liu K, Hou Y, Zheng J Abstract The aim of the present study was to investigate the expression levels of interleukin-15 (IL-15) and interleukin-17 (IL-17) in synovial fluid of rheumatoid arthritis (RA) animal model, and to investigate their correlations with RA. A total of 100 Wistar rats were selected, among which 60 rats were used to establish the collagen II-induced arthritis (CIA) model as the model observation group, and the remaining 40 rats were used as blank control group. The levels of IL-15 and IL-17 in synovial fluid were detected via enzyme-linked immunosorbent assay (ELISA...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
We present the results of a long term observational study of RA-1 (Ayurvedic drug) used in the treatment of rheumatoid arthritis (RA).ObjectiveThe objective was to study safety of long term use of RA-1 for treatment of rheumatoid arthritis (RA).Materials and methodsOn completion of a 16 week randomized controlled study, 165 consenting volunteer patients were enrolled into a three year open label phase (OLP) study. Patients were symptomatic with persistent active disease and naïve for disease modifying anti-rheumatic drugs (DMARD). 57 patients were on fixed low dose prednisone. Patients were examined every 10–14 ...
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
ConclusionsUsing an evidence-based approach followed by expert consensus, this initiative should improve the assessment and optimization of adherence in chronic inflammatory rheumatic disorders.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Publication date: Available online 19 September 2018Source: Joint Bone SpineAuthor(s): Minh Vu Chuong Nguyen, Annie Adrait, Athan Baillet, Candice Trocmé, Jacques-Eric Gottenberg, Philippe Gaudin
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Publication date: Available online 19 September 2018Source: Joint Bone SpineAuthor(s): Renaud Felten, Florence Scher, Jean Sibilia, François Chasset, Laurent ArnaudABSTRACTThere have been many advances in the diagnosis and therapeutic management of Systemic Lupus Erythematosus (SLE) over the past decades. Following more than eleven centuries of therapeutic uncertainty, the discovery of the therapeutic properties of glucocorticoids is without any doubt one of the most significant advance in the field of autoimmune diseases. The many progresses made by rapidly growing chemical industry of the 19th century chemistry ha...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
Optetrak Logic CC Stem Extension, 22mm x 160mm The OPTETRAK Logic CC Total Knee System is indicated for use in skeletally mature individuals undergoing primary surgery for total knee replacement due to osteoarthritis, osteonecrosis, rheumatoid arthritis and/or post-traumatic degenerative problems.
Source: Medical Device Recalls - Category: Medical Devices Source Type: alerts
AMSTERDAM—With new therapies coming into the marketplace, researchers are working to tease out the risk of infection for rheumatoid arthritis (RA) patients. Existing data suggest the risk of infections—even fatal ones—is real. But over time, improvements have taken hold, particularly for tuberculosis, according to an infectious disease expert at EULAR: the Annual European Congress of... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Biologics & Biosimilars Conditions Drug Updates Rheumatoid Arthritis Infection Tuberculosis Source Type: research
AMSTERDAM—Early identification and treatment of rheumatoid arthritis (RA) are two of the most pressing concerns in the field, an expert said at EULAR: the Annual European Congress of Rheumatology. He described the latest efforts to identify patients at risk of RA development and insights on quick referral to rheumatologists. Karim Raza, BM, BCh, PhD, Arthritis... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Rheumatoid Arthritis Classification Criteria general practitioners GPs Rheumatoid Factor Tenosynovitis Source Type: research
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