Impact of Sedentary Time on Chronic Kidney Disease (CKD) and Disability Incidence in Community-Dwelling Japanese Older Adults: A 4-Year Prospective Cohort Study.

This study examined the association between the estimated glomerular filtration rate (eGFR) and disability incidence according to sedentary time in community-dwelling older Japanese adults. This prospective cohort study sampled 5104 community-dwelling older adults (≥ 65 years) enrolled in a health promotion study in a general population. The participants (n = 4457, ≥ 65 years) were monitored for inclusion in the long-term care insurance (LTCI) system for 4 years. This study used blood samples to assess eGFR. Cox proportional regression analysis was used to determine predictors of disability. In total, 461 participants (10.3%) became newly certified as needing LTCI services. Cox regression models were adjusted for multiple confounders: eGFR
Source: Journal of Aging and Physical Activity - Category: Geriatrics Tags: J Aging Phys Act Source Type: research

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ConclusionDialysis of children before KTx was a particularly larger burden for caregivers. The child ’s comorbidities and social adaptation problems might be focused after KTx, we need to evaluate for more long-term QOL of caregivers.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
We report a case of four years old boy admitted with acute respiratory failure. Physical examination revealed: irritability, purple subcutaneous hard nodules, tachypnea, dry spasmodic cough, respiratory rate 45/min, heart rate 110/min, blood pressure 100/60 mmHg, with normal heart sounds, no murmurs, hepatomegaly with hepato-jugular reflux. He was diagnosed at 2 years old with stage 5 chronic kidney disease due to untreated posterior urethral valve, and subsequently started peritoneal dialysis. He developed severe renal osteodystrophy, refractory to standard phosphate binders. Diagnoses: Pathology examination revealed t...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Abstract Acute kidney injury (AKI) is pervasive, affecting a significant proportion of critically ill and noncritically ill children. Recent data demonstrate a clear independent association of escalating AKI severity with not only mortality, but also with longer-term disability and chronic kidney disease in children. The paradigm has shifted-patients are no longer dying with AKI, but rather from AKI. In this review, AKI is described in the paradigms of "past," "present," and "future" to stimulate a reassessment of our understanding of this organ dysfunction syndrome. Current treatment...
Source: Pediatric Annals - Category: Pediatrics Authors: Tags: Pediatr Ann Source Type: research
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The Centers for Medicare and Medicaid Services (CMS) has posted the calendar year (CY) 2019 Advance Notice and Call Letter explaining proposed methodological and payment changes for Medicare Advantage (MA) plans, as well as key policies under Part D. The proposal includes opioid prescribing limits in Medicare Part D and changes to MA utilization of encounter data. It also expands MA supplemental benefits and reducing payments to Employer Group Waiver Plans. Net Payment Impact For MA plans, CMS estimates a +1.84 percent net increase on average relative to CY 2018 because of Adv...
Source: Policy and Medicine - Category: American Health Authors: Source Type: blogs
In older people with chronic kidney disease (CKD) and comorbidities, the risk of death or disability may overshadow the risk of kidney failure. To help refine this we did a retrospective population-based cohort study to evaluate the relative likelihood of adverse outcomes as functions of age and comorbidity burden among 47,228 adults with severe non –dialysis dependent CKD. We identified comorbidities using 29 validated algorithms applied to administrative data and assessed death, end-stage renal disease (ESRD), cardiovascular disease (CVD) events, and long-term care.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Clinical Investigation Source Type: research
CONCLUSIONS: This study indicates that uremic sarcopenia and dynapenia are prevalent in PD patients in Tehran, Iran. These conditions may contribute to physical disability, decreased the quality of life, increased morbidity, and a high mortality rate. Therefore, prevention and treatment of uremic sarcopenia and dynapenia are necessary for Iranian PD patients. PMID: 29421778 [PubMed - in process]
Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
I greatly appreciate the study by Silverstein et  al. on the effect of diabetes for the change of quality of life after decompression spinal surgery [1]. The authors used the EuroQol 5-Dimensions (EQ-5D), the Pain Disability Questionnaire (PDQ), and the Patient Health Questionnaire 9 (PHQ-9). Multiple regression analysis and logistic regression a nalysis were applied to assess the effect of diabetes on subsequent change in quality of life. Chronic kidney disease and diabetes were identified as significant independent predictors for diminished improvement in EQ-5D, and diabetes was also a significant independent predic...
Source: The Spine Journal - Category: Orthopaedics Authors: Source Type: research
From estimates of the Institute of Health Metrics and Evaluation,1 chronic kidney disease (CKD) was among the top 10 contributors to age-standardized disability-adjusted life years in Central Latin America in 2015, and in the preceding 15 years its ranking rose from 18th to fifth place. CKD-attributable disability-adjusted life years are higher among men than women, although rates in women are increasing more rapidly. Over the past 20 years, many community reports2 have described an excess of cases of CKD in this region, specifically a form of chronic interstitial nephritis (termed CKD of nontraditional causes or CKDnT).
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrologists Sans Fronti ères Source Type: research
Older patients with depression may be at greater risk of death following a procedure to replace a damaged aortic valve of the heart, reports astudy published today inJAMA Cardiology.“The clinical implications of our findings support active screening for depression before and after aortic valve procedures to identify patients who may benefit from further psychiatric evaluation for the diagnosis and treatment of a depressive disorder,” wrote Jonathan Afilalo, M.D., M.Sc., of Jewish General Hospital, Montreal, and colleagues.The study included patients who were at least 70 years of age with symptomatic aortic sten...
Source: Psychiatr News - Category: Psychiatry Tags: aortic stenosis aortic valve replacement cerebrovascular disease COPD depression diabetes Geriatric Depression Scale Short Form hypertension Jonathan Afilalo kidney disease Source Type: research
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