Impact of Sedentary Time on Chronic Kidney Disease (CKD) and Disability Incidence in Community-Dwelling Japanese Older Adults: A 4-Year Prospective Cohort Study.

This study examined the association between the estimated glomerular filtration rate (eGFR) and disability incidence according to sedentary time in community-dwelling older Japanese adults. This prospective cohort study sampled 5104 community-dwelling older adults (≥ 65 years) enrolled in a health promotion study in a general population. The participants (n = 4457, ≥ 65 years) were monitored for inclusion in the long-term care insurance (LTCI) system for 4 years. This study used blood samples to assess eGFR. Cox proportional regression analysis was used to determine predictors of disability. In total, 461 participants (10.3%) became newly certified as needing LTCI services. Cox regression models were adjusted for multiple confounders: eGFR < 45 mL/min/1.73 m2 (hazard ratio [HR] = 1.741; 95% confidence interval [CI] [1.193-2.539]) and eGFR < 45 mL/min/1.73 m2 with high sedentary time (≥ 8 hours) (HR = 4.367; 95% CI [2.021-9.438]) remained significantly associated with disability incidence. Our findings suggest that in the case of CKD, the disability incidence rate may be affected by sedentary time. PMID: 29989467 [PubMed - as supplied by publisher]
Source: Journal of Aging and Physical Activity - Category: Geriatrics Tags: J Aging Phys Act Source Type: research