Impact of Sedentary Time on Chronic Kidney Disease (CKD) and Disability Incidence in Community-Dwelling Japanese Older Adults: A 4-Year Prospective Cohort Study.

This study examined the association between the estimated glomerular filtration rate (eGFR) and disability incidence according to sedentary time in community-dwelling older Japanese adults. This prospective cohort study sampled 5104 community-dwelling older adults (≥ 65 years) enrolled in a health promotion study in a general population. The participants (n = 4457, ≥ 65 years) were monitored for inclusion in the long-term care insurance (LTCI) system for 4 years. This study used blood samples to assess eGFR. Cox proportional regression analysis was used to determine predictors of disability. In total, 461 participants (10.3%) became newly certified as needing LTCI services. Cox regression models were adjusted for multiple confounders: eGFR
Source: Journal of Aging and Physical Activity - Category: Geriatrics Tags: J Aging Phys Act Source Type: research

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We report that the bone marrow stromal cell senescence is driven by p16INK4a expression. The p16INK4a-expressing senescent stromal cells then feedback to promote AML blast survival and proliferation via the SASP. Importantly, selective elimination of p16INK4a-positive senescent bone marrow stromal cells in vivo improved the survival of mice with leukemia. Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML induced NOX2-derived superoxide. Finally, using the p16-3MR mouse model we show that by targeting NOX2 we reduced bone marrow stromal cell senescence and consequently reduced A...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Hypertension is the leading cause of death, premature morbidity, and disability-adjusted life years worldwide. Chronic hypertension is a predisposing factor to the development of coronary artery disease (CAD), cerebrovascular disease (CeVD), systemic atherosclerosis, congestive heart failure (CHF), chronic kidney disease (CKD) and dementia (1,2). Despite various regional and global efforts to control hypertension, its prevalence remains high and is estimated to impact more than 1.13 billion people worldwide (3).
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Authors: Ortiz A, Sanchez-Niño MD, Crespo-Barrio M, De-Sequera-Ortiz P, Fernández-Giráldez E, García-Maset R, Macía-Heras M, Pérez-Fontán M, Rodríguez-Portillo M, Salgueira-Lazo M, Sánchez-Álvarez E, Santamaría-Olmo R, Simal-Blanco F, Pino-Pino MD Abstract The Global Burden of Disease (GBD) study measures the health of populations worldwide and by country on an annual basis and aims at helping guide public policy on health issues. The GBD estimates for Spain in 2016 and recent trends in mortality and morbidity from 2006 to 2016 were recent...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
Healthcare resources and reduction of risk factors, including dietary and lifestyle changes, are needed to curb the growing chronic kidney disease burden, a study has found.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Nephrology News Source Type: news
Introduction: Patients with Multiple Myeloma (MM) are living longer due to therapeutic advancements. With improving MM outcomes, supportive care measures focused on optimizing quality of life and minimizing treatment-related toxicities have become more relevant. Patients with MM report high rates of bone pain, skeletal-related events and infections for which bisphosphonates, influenza vaccination, and antiviral prophylaxis have been recommended. The extent to which these supportive care measures are used during routine clinical practice and the factors predicting utilization remain unknown.Methods: We selected older adults...
Source: Blood - Category: Hematology Authors: Tags: 902. Health Services Research-Malignant Diseases: Quality Of Life Studies Source Type: research
ConclusionDialysis of children before KTx was a particularly larger burden for caregivers. The child ’s comorbidities and social adaptation problems might be focused after KTx, we need to evaluate for more long-term QOL of caregivers.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
CONCLUSION: . - Diabetes and hyperglycaemia constitute a huge health burden in China. The substantial increase in diabetes-related burden represents an ongoing challenge, given the rapidly ageing Chinese population. Thus, a targeted control and preventative strategy needs to be developed at risk-factor level to reduce this burden. PMID: 30196138 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Tags: Diabetes Metab Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
A good understanding of disease burden is the first step in formulating a response to it. Analysis of the Global Burden of Disease 2016 dataset shows an 87% rise in the global burden of chronic kidney disease and a doubling of chronic kidney disease deaths between 1990 and 2016. Countries with a lower level of socioeconomic development and poorer access to quality health care experience a higher chronic kidney disease burden. Reductions in global disability-adjusted life-years over time indicate progress, but deviations from this trend in some geographies present a call to action.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
The last quarter century witnessed significant population growth, aging, and major changes in epidemiologic trends, which may have shaped the state of chronic kidney disease (CKD) epidemiology. Here, we used the Global Burden of Disease study data and methodologies to describe the change in burden of CKD from 1990 to 2016 involving incidence, prevalence, death, and disability-adjusted-life-years (DALYs). Globally, the incidence of CKD increased by 89% to 21,328,972 (uncertainty interval 19,100,079 – 23,599,380), prevalence increased by 87% to 275,929,799 (uncertainty interval 252,442,316–300,414,224), death due...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Clinical Investigation Source Type: research
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