ILD in Scleroderma: Response Markers Remain Elusive

(MedPage Today) -- Proxies for active inflammation failed to predict cyclophosphamide effectiveness
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news

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Publication date: Available online 19 October 2019Source: Autoimmunity ReviewsAuthor(s): Jelena Blagojevic, Paul Legendre, Marco Matucci-Cerinic, Luc MouthonAbstractIn systemic sclerosis (SSc), the use of corticosteroids (CS) is controversial due to their association with scleroderma renal crisis (SRC). However, patients with very early and early disease, characterised by main inflammatory component, may benefit from CS therapy.The aim of this review is to discuss pros and cons of CS treatment in SSc, providing current evidence about the use of CS in SSc. Moreover, we discuss also the underlying pathogenetic mechanisms tha...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
No abstract available
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Letters to the Editor Source Type: research
Publication date: Available online 18 October 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Sirajum Munira, Lisa Christopher-StineAbstractMyositis and scleroderma are both rare autoimmune diseases with female predominance and often occur before and during reproductive years. The rarity of diseases explains the low frequency of concurrent disease and pregnancy. Like other autoimmune diseases, myositis and scleroderma may be more active during pregnancy as well. To date, many patients with myositis and scleroderma can have favorable pregnancy outcomes with careful management. This cha...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
Condition:   Systemic Sclerosis Intervention:   Other: stool sampling Sponsor:   Hôpital Européen Marseille Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Scleromyxedema is a rare, mucinous skin disorder of unknown origin, one of a number of conditions that mimic systemic sclerosis. Although cases of scleromyxedema remain rare, a better understanding of its mechanisms of action could have implications for the research and treatment of scleroderma and related autoimmune conditions, says Laura K. Hummers, MD, ScM, co-director... [Read More]
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Conditions Research Reviews intravenous immunoglobulins IVIg mimics Scleromyxedema Source Type: research
New England Journal of Medicine,Volume 381, Issue 16, Page 1595-1597, October 2019.
Source: New England Journal of Medicine - Category: Internal Medicine Source Type: research
ConclusionThis review provides an assessment of the current estimates of disease prevalence and incidence of SSc. The epidemiological burdens of SSc vary among different regions of the world. The epidemiological data need to be interpreted with caution considering the methodological differences in deriving these estimates.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract Inflammatory cell infiltrates are a prominent feature of aberrant vascular remodeling in pulmonary arterial hypertension (PAH), suggesting that immune effector cells contribute to disease progression. Genome-wide blood expression profiling studies have attempted to better define this inflammatory component of PAH pathobiology, but have been hampered by small sample sizes, methodological differences and very little gene-level reproducibility. The current meta-analysis (seven studies; 156 PAH patients/110 healthy controls) was performed to assess the comparability of data across studies and to possibly deri...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - Category: Cytology Authors: Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
This study was designed to identify miRNAs that are differentially expressed in SSc and might be potentially contributing to the disease etiopathogenesis or be used for diagnostic purposes. Thus, we compared the expression pattern of multiple miRNAs in serum of 10 SSc patients to 6 healthy controls using microarray analysis, and RT-qPCR to confirm the obtained results. In addition, bioinformatics analysis was performed to explore miRNAs target genes and the signaling pathways that may be potentially involved in SSc pathogenesis.Our study shows a different expression of 15 miRNAs in SSc patients. We identified that miR-4484...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research
Systemic sclerosis (SSc) is a potentially fatal autoimmune disease that leads to extensive fibrosis of the skin and internal organs. Invariant natural killer T (iNKT) cells are potent immunoregulatory T lympho...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
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