Medical News Today: What is pregabalin?
Pregabalin oral capsule is used to treat neuropathic pain and fibromyalgia. It ’s also used with other seizure drugs to treat partial onset seizures. Pregabalin oral capsule is only available as the brand-name drug Lyrica. It's not available as a generic drug. Learn about side effects, warnings, dosage, and more.
This study investigated the relation of fibromyalgia severity on the acute pain response following isometric and dynamic muscle contractions. Thirty-four participants with fibromyalgia (52.5 ±11.9yr.; BMI:31.1±6.1; 32 women) completed a quiet rest and two randomized exercise sessions (isometric or dynamic) of the elbow flexors matched for intensity, duration, and duty-cycle. The quiet rest session included assessment of fibromyalgia severity (Fibromyalgia Symptom Scale [FS]), conditio ned pain modulation (CPM), and mechanical temporal summation (TS).
The first scientific reference of fibromyalgia as a medical disorder occurred in 1981. Since then, pain management experts have continuously debated diagnosis criteria, potential pathologies, and viable treatment options due to the complex nature of the disease. For both patient and clinician, the efficacy of current pharmacologic treatments can be frustrating. The clinical benefit of medications is often modest at best. In fact, the 2016 European League Against Rheumatism (EULAR) guideline for managing fibromyalgia could only endorse a 'weak for' recommendation for medication management based on currently available evidence.
Cognitive problems in fibromyalgia (FM), or “fibrofog,” are highly prevalent but not well-characterized. Research shows that deficits in cognitive performance in FM only emerge in the context of a stimulating testing environment, suggesting a potentially important role for distraction in the experience of both subjective (perceived) and o bjective (performed) fibrofog. Unexplored to date is the role of real-world distractions in fibrofog in everyday life. To address limitations in our understanding of fibrofog in daily life, we conducted a study of ambulatory subjective and objective cognitive function in a sam...
Most people with fibromyalgia (FM) report “fibrofog”, or cognitive dysfunction. To better characterize fibrofog in daily life, we conducted an ambulatory study of subjective and objective cognitive function in real-world settings in persons with FM and sex-, age-, and education-matched healthy controls (HC) to test whether: 1) people wi th FM demonstrate poorer cognitive function on ambulatory measures; 2) people with FM demonstrate a different diurnal pattern of cognitive function; and 3) subjective cognitive function corresponds more highly with objective cognitive measures in HC compared to FM.
Treating chronic low back pain (CLBP) with spine-focused interventions is common, potentially dangerous, and often ineffective. We posit that CLBP in older adults is a geriatric syndrome – a final common pathway for the expression of multiple contributors. We have published evidence and expert consensus-based algorithms to guide evaluation and treatment of key biopsychosocial CLBP contributors in older adults – hip osteoarthritis, myofascial pain, fibromyalgia, sacroiliac joint syndrome, lumbar spinal stenosis, leg length inequality, lateral hip/thigh pain, anxiety, depression, insomnia, and maladaptive coping....
Approximately 18% of patients undergoing lower extremity joint arthroplasty fail to significantly improve following arthroplasty. We previously demonstrated that higher levels of fibromyalgia (FM) symptoms ( “FMness”) prior to surgery are associated with less postoperative improvement. Sleep disturbances, which are a core symptom domain in FM, are present in greater than 90% of chronic pain patients. Here, we consider the impact of self-reported sleep disturbances on knee arthroplasty outcomes six m onths after surgery (n=74, 54% female), and on psychophysical pain sensitivity in a subset of these patients preoperatively (n=43).
The objectives of this study were to describe physical and psychosocial outcomes of youth diagnosed with JFM in early adulthood ( ∼ 8-years after initial assessment), examine longitudinal trajectories of pain and depressive symptoms from adolescence to young adulthood, and examine the impact of pain and depressive symptoms on physical functioning over time.
The objective of this study was to identify potential biomarkers in individuals with FM, and to correlate these putative biomarkers with FM-symptoms using a targeted metabolomics approach. The current study was a secondary analysis from baseline data taken in the Fibromyalgia Activity Study with TENS (FAST). We analyzed plasma samples and baseline patient-reported outcomes for resting pain and fatigue from 59 women with FM (mean ±SD; age=49.69±11.54, BMI=35.23±10.91) matched with 38 healthy controls (HC) (age=51.0±11.46, BMI=32.33±8.66).
Fibromyalgia (FM) is a vexing pain condition that primarily impacts women with a history of trauma. Women veterans experience posttraumatic stress disorder in their lifetime almost twice as often as their civilian counterparts (13.4% vs. 8.0%). Due to their high rates of trauma exposure, women veterans are at an increased risk of developing FM, with rates higher than those in the civilian population (5.1% vs. 2.0%). The present pilot study seeks to identify preferences for care for women veterans with FM at the Boston VA Healthcare System (VABHS) through qualitative interviews with patients and health care providers.
The purpose of this study was to determine the relation between the acute change in experimental and self-reported pain after isometric and dynamic submaximal resistance exercise in people with fibromyalgia. Thirty-four participants (52.5 ±11.9 yr, BMI:31.1±6.1; 32 women) with fibromyalgia completed one familiarization session and two randomized exercise sessions (isometric or dynamic) of the right elbow flexors matched for time, intensity, and duty cycle. Experimental pain was quantified via pressure pain thresholds (PPTs) at the right biceps brachii and quadriceps muscles and mechanical temporal summation (...