Adenosine Receptors Influence Hypertension in Dahl Salt-Sensitive RatsNovelty and Significance [Adenosine Receptors]

The influence of adenosine receptors on blood pressure in salt-sensitive hypertension is unknown. Here, we examined the effects of salt diets on arterial blood pressures (radiotelemetry) in female and male Dahl salt-sensitive wild-type versus female and male Dahl salt-sensitive A1, A2A, or A2B receptor knockouts (A1KOs, A2AKOs, and A2BKOs, respectively). At baseline, all rats were on a 0.3% salt diet; then separate groups were switched to either 4% or 8% salt diet for 2 weeks. Compared with wild-types, baseline pressures were not affected by knockout of A1 or A2B receptors; yet, mean, systolic, and diastolic pressures were significantly (P

Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Edwin K. Jackson, Delbert G. Gillespie, Zaichuan Mi, Dongmei Cheng Tags: Animal Models of Human Disease, Basic Science Research, Hemodynamics, Hypertension Original Articles Source Type: research