Renin-Angiotensin-Aldosterone Profiles in Pregnant Women With Chronic HypertensionNovelty and Significance [Preeclampsia, Pregnancy, and Hypertension]

Pregnant women with chronic hypertension are at risk for increased blood pressure and superimposed preeclampsia (SPE) in late pregnancy. Alterations in the renin-aldosterone system are a feature of normal pregnancy; however, their role in chronic hypertension with and without SPE is less clear. We performed a prospective, longitudinal trial of 108 women with chronic hypertension and measured plasma renin activity (PRA), 24-hour urine sodium, urine potassium, and urine aldosterone (Ualdo) at 12, 20, 28, and 36 weeks and postpartum. SPE developed in 34% of pregnancies. PRA was lower in women who developed SPE at weeks 28 (5.99 versus 6.22 ng/mL per hour; P
Source: Hypertension - Category: Cardiology Authors: Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Physiology, Hypertension, Preeclampsia Original Articles Source Type: research