Does Obstructive Sleep Apnea Influence Blood Pressure and Arterial Stiffness in Response to Antihypertensive Treatment?Novelty and Significance [Obstructive Sleep Apnea]

In this study, we recruited hypertensive patients who underwent treatment with a 30-day regimen of hydrochlorothiazide 25 mg plus enalapril (20 mg BID) or losartan (50 mg BID) and were assessed with a baseline clinical evaluation, polysomnography, 24-hour ambulatory BP monitoring, and carotid-femoral pulse wave velocity. All the examinations except for polysomnography were repeated at 6 and 18 months of follow-up. We studied 94 hypertensive patients (mean age, 55±9 years). The frequency of OSA was 55%. Compared with baseline, we did not observe significant differences between groups in 24-hour BP, daytime systolic and diastolic BPs, or night-time systolic BP at 6 and 18 months. The BP control rate at 24 hours (

Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Fernanda Fatureto–Borges, Raimundo Jenner, Valeria Costa–Hong, Heno F. Lopes, Sandra H. Teixeira, Elias Marum, Dante A.M. Giorgi, Fernanda M. Consolim–Colombo, Luiz A. Bortolotto, Geraldo Lorenzi–Filho, Eduardo M. Krieger, Luciano Tags: Hypertension Original Articles Source Type: research