Suppression of Endothelial-to-Mesenchymal Transition by SIRT (Sirtuin) 3 Alleviated the Development of Hypertensive Renal InjuryNovelty and Significance [Kidney]

In conclusion, these results established the SIRT3-Foxo3a-catalase pathway as a critical factor in the maintenance of endothelial homeostasis and point to an important role of EndoMT in the vascular pathology of renal fibrosis, which may provide a new therapeutic target to impede the progression of hypertensive renal injury.

Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Jing-rong Lin, Yan-jun Zheng, Ze-bei Zhang, Wei-li Shen, Xiao-dong Li, Tong Wei, Cheng-chao Ruan, Xiao-hui Chen, Ding-liang Zhu, Ping-jin Gao Tags: Endothelium/Vascular Type/Nitric Oxide, Oxidant Stress, Vascular Biology, Hypertension Original Articles Source Type: research