Childhood trauma and emotion regulation: The moderator role of BDNF Val66Met
Publication date: Available online 11 July 2018Source: Neuroscience LettersAuthor(s): Mirela I. Bîlc, Romana Vulturar, Adina Chiș, Mădălina Buciuman, Daria Nuţu, Ioana Bunea, Aurora Szentágotai-Tătar, Andrei C. MiuAbstractEmotion regulation difficulties have been involved in multiple forms of psychopathology and may represent an important focus for current efforts to understand the biological mechanisms underlying transdiagnostic symptoms. The present study investigated a gene-environment interaction (G × E) in reappraisal, a form of emotion regulation that has been extensively linked to psychopathology. In light of recent meta-analytic evidence of its consistent role in depression and anxiety disorders, this study focused on the Val66Met (rs6265) single-nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene and examined its moderator role in the relation between childhood trauma and reappraisal. A sample of N = 266 participants were genotyped for BDNF Val66Met, filled in a self-report measure of childhood trauma, and underwent a cognitive task designed to assess reappraisal ability. The results indicated that, as expected, BDNF Val66Met was a significant moderator in the relation between childhood trauma and reappraisal. There was a negative relation between the number of childhood traumatic events and reappraisal ability in BDNF Met carriers, but not Val homozygotes. This finding suggests that BDNF Va...
Swatee Surve's video game tackles anxiety and depression with the help of Socks the fox.
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Authors: Verdolini N, Menculini G, Perugi G, Murru A, Samalin L, Angst J, Azorin JM, Bowden CL, Mosolov S, Young AH, Barbuti M, Popovic D, Vieta E, Pacchiarotti I, BRIDGE-II-MIX Study Group Abstract OBJECTIVE: This post hoc analysis of the BRIDGE-II-MIX study is aimed at evaluating affective lability (AL) as a possible clinical feature of mixed depression and assessing the relationship with atypical depressive features, particularly mood reactivity (MR). METHODS: In the BRIDGE-II-MIX multicenter, cross-sectional study, 2,811 individuals suffering from a major depressive episode (MDE; DSM-IV-TR criteria), in the...
Conclusion: Improvement of OAB symptoms helps relieve anxiety, but not depression.Urol Int
We’ve all experienced it – that feeling of smug happiness at another person’s misfortune. From someone slipping on a banana peel to a jerk receiving a dose of instant karma, there’s something satisfying about this strange emotion. Why is that? Are we living in an “Age of Schadenfreude”? Should we feel guilty about feeling it? And for crying out loud, how do we say it in English? Listen in to find out! Subscribe to Our Show! And Remember to Review Us! About Our Guest Dr. Tiffany Watt Smith is a cultural historian and author of The Book of Hu...
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ConclusionsThe findings reaffirm the importance of using active control groups and considering the capacities of facilitators in evaluating the effects of mindfulness-based interventions. Testing mindfulness-based interventions in low-resource, non-Western school settings require deeper contextual adaptation and facilitator preparation.
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