Report: Dog Illness Can Spread to Humans

A strain of bacterium carried by dogs -- Brucella canis -- could be widespread in humans, according to a report from Texas A&M University.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Conclusion: According to the findings of the present research, the microbially synthesized Ag-Cu nanoalloy demonstrated antibacterial effects on the majority of the bacteria studied even at 0.01 μg/μL. However, complementary investigations should be conducted into the safety of this nanoalloy for in vivo or systemic use. PMID: 30112155 [PubMed]
Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
THURSDAY, Aug. 16, 2018 -- Brucella canis is an under-recognized infection in dogs that poses a threat to human health, according to a report published in the August issue of the U.S. Centers for Disease Control and Prevention's Emerging Infectious...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
In this study, we aimed to evaluate the diagnostic value of hematological inflammatory markers in Brucella epididymo-orchitis (BEO), and to investigate the utility of these markers for differential diagnosis from non-Brucella epididymo-orchitis (non-BEO). Materials and Methods: We retrospectively reviewed the records of 22 BEO and 50 non-BEO patients. Hematological parameters were recorded and compared between the two groups. The main diagnostic criteria for BEO were positive clinical findings (i.e., testicular pain, tenderness and scrotal swelling), a positive Rose Bengal test result, standard tube agglutination (STA) tit...
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
Arnaud Machelart, Georges Potemberg, Laurye Van Maele, Aurore Demars, Maxime Lagneaux, Carl De Trez, Catherine Sabatel, Fabrice Bureau, Sofie De Prins, Pauline Percier, Olivier Denis, Fabienne Jurion, Marta Romano, Jean-Marie Vanderwinden, Jean-Jacques Letesson, Eric Muraille
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Abstract Brucellosis is a worldwide zoonosis caused by Brucella species and represents a serious threat to both human and animal health. Omp25 is an important immunogenic and protective antigen in Brucella species; however, the functional mechanism of Omp25 in macrophages has not yet been elucidated. Here, we constructed a Brucella melitensis omp25 deletion mutant (M5-90-Δ omp25) and performed microRNA (miRNA) profiling of infected RAW264.7 cells. Eight differentially expressed miRNAs ( mmu-miR-146a-5p, mmu-miR-155-5p, mmu-miR-3473a, mmu-miR-149-3p, mmu-miR-671-5p, mmu-miR-1224-5p, mmu-miR-1895, and mmu-miR-...
Source: Innate Immunity - Category: Allergy & Immunology Authors: Tags: Innate Immun Source Type: research
This study was conducted to determine the clinical manifestations, antibiotic susceptibility pattern, treatment and outcome of culture confirmed brucellosis. Adult patients with culture confirmed brucellosis who presented to a large teaching hospital in South India between 2009 and 2015 were included. A diagnosis of brucellosis was confirmed on automated culture. Clinical profile, laboratory parameters, drug susceptibility, treatment and outcome were documented by reviewing the medical records. The cohort comprised of 22 patients with mean ± SD age of 42 ± 13 years. Twenty one (95.5%) was male. Thirteen (59&#...
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
Abstract Brucella melitensis is the causative pathogen of the zoonotic disease brucellosis in China. This work focused on analyses of genetic features represented by nucleotide, synonymous codon and amino acid usages at gene levels of B. melitensis strain QY1 isolated from China. Although nucleotide usage biases at different codon positions all work on synonymous codon usage bias, nucleotide usage biases at the 1st and 3rd positions play more important roles in codon usages. Mutation pressure caused by nucleotide composition constraint influences the formation of over-representative synonymous codons, but neighbor...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
CONCLUSIONS: This report describes an emergent case and the response to two consecutive outbreaks of occupational brucellosis among workers in a pharmaceutical manufacturing enterprise. The hierarchical control strategy used in this case may prevent new outbreaks, and several lessons can be learned from this event. PMID: 30068856 [PubMed - as supplied by publisher]
Source: Journal of Occupational Health - Category: Occupational Health Tags: J Occup Health Source Type: research
We report an unusual case of pacemaker-related endocarditis due to Brucella melitensis in a patient with previous history of neurobrucellosis. Our patient was admitted to a hospital with severe swelling of his pacemaker pocket implanted 8 years earlier for sick sinus syndrome. Although pocket site cultures were positive for Brucella but blood cultures were not and serologic titer by the Rose Bengal test was positive. Transesophageal echocardiography showed two vegetations on the pacemaker leads. The patient was treated with doxycycline, rifampin and gentamicin with full recovery and the entire pacemaker apparatus was surgi...
Source: IDCases - Category: Infectious Diseases Source Type: research
Brucella melitensis bacteria cause persistent, intracellular infections in small ruminants as well as in humans, leading to significant morbidity and economic loss worldwide. The majority of experiments on the tr...
Source: BMC Molecular Biology - Category: Molecular Biology Authors: Tags: Research article Source Type: research
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