Pulmonary Hypertension, Mortality, and Cardiovascular Disease in CKD and ESRD Patients: A Systematic Review and Meta-analysis

ConclusionsPulmonary hypertension is associated with a substantially increased risk for death and cardiovascular events in patients with CKD and ESRD. Risk is higher in patients with ESRD receiving dialysis compared with patients with CKD stages 1 to 5. Understanding the effect of interventions to lower pulmonary artery pressure on the survival of these patents awaits their evaluation in randomized controlled trials.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research

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Authors: Moreno JA, Gomez-Guerrero C, Mas S, Sanz AB, Lorenzo O, Ruiz-Ortega M, Opazo L, Mezzano S, Egido J Abstract INTRODUCTION: Diabetic nephropathy (DN) is the leading cause of chronic kidney disease (CKD) and end stage renal disease (ESRD). Beyond the new anti-diabetic drugs that possess markedly cardiovascular and renal protective effects, no novel direct therapies for DN have become available on the market in the last twenty years. Recently well-designed clinical trials for the treatment of DN, with attractive pathogenetic rationale, e.g. bardoxolone and atrasentan, were cancelled or stopped because of safet...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Conclusions: NVI following KD is more common after lower energy-level mechanisms. Obesity is associated with NVI in lower energy-level mechanisms. Physicians should be vigilant in screening for NVI in the setting of KD even with seemingly benign mechanisms of injury, especially in patients with obesity. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
Biolife4D has achieved a milestone in its ultimate quest to develop human organs for transplant. The company recently announced that it has developed a cardiac patch using a highly specialized 3D printer designed to protect living cells during the printing process. The patch is designed to help patients recover heart function after an acute myocardial infarction, said Ravi Birla, PhD, the company’s chief science officer, in an interview with MD+DI. “Over several weeks, acute myocardial infarction results in scar formation and progresses to chronic heart failure, severely damp...
Source: MDDI - Category: Medical Devices Authors: Tags: 3-D Printing Source Type: news
Publication date: Available online 18 October 2018Source: Journal of Membrane ScienceAuthor(s): Jun Feng, Jianchao Chen, Biaowen Wei, Shijun Liao, Yigang Yu, Xiuhua LiAbstractA series-connected tetracation cross-linker, DB, was synthesized successfully from 1,4-diazabicyclo[2.2.2]octane (DABCO) and dibromomethane. Which had two terminal tertiary amine groups and reacted with the bromomethylated poly(aromatic ether sulfone) (BPAES) based on 9,9-bis(4-hydroxyphenyl)fluorene and the other copolycondensation monomers giving a series of series-connected hexacations cross-linked anion exchange membranes, QPAES-DBs, for acid reco...
Source: Journal of Membrane Science - Category: Materials Science Source Type: research
Conclusion The intrarenal RAS is activated in kidney transplant donors immediately after kidney donation, independent of the systemic BP and filtration of increased plasma AGT, due to augmented inflammation. PMID: 30333423 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Sachiyo O, Masahiro T, Tsutomu T, Makoto I, Yutaka H, Nobumasa M, Takamichi K, Nozomi O, Shinpei M, Kazuhiro T, Yusuke K, Masanori O, Yusuke K, Yasuhisa H, Kazuo H, Yasumasa N Abstract Fanconi anemia (FA) is a disorder of chromosomal fragility characterized by progression to aplastic anemia, myelodysplastic syndrome, and leukemia. FA patients are also predisposed to solid cancers. A case of FA in an adult patient who developed tongue and superficial esophageal cancers following hematopoietic stem cell transplantation is reported. This case was considered significant because it is the first reported case of...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Source: Nephrology Dialysis Transplantation - Category: Urology & Nephrology Authors: Tags: HYPERTENSION. CLINICAL Source Type: research
Source: Nephrology Dialysis Transplantation - Category: Urology & Nephrology Authors: Tags: CHRONIC KIDNEY DISEASE. PATHOPHYSIOLOGY, PROGRESSION & amp; RISK FACTORS - 2 Source Type: research
Source: Nephrology Dialysis Transplantation - Category: Urology & Nephrology Authors: Tags: CHRONIC KIDNEY DISEASE. CLINICAL EPIDEMIOLOGY - 2 Source Type: research
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