Acute Kidney Injury in Sugarcane Workers at Risk for Mesoamerican Nephropathy

Publication date: Available online 2 July 2018Source: American Journal of Kidney DiseasesAuthor(s): Joseph Kupferman, Oriana Ramírez-Rubio, Juan José Amador, Damaris López-Pilarte, Elissa H. Wilker, Rebecca L. Laws, Caryn Sennett, Ninoska Violeta Robles, Jorge Luis Lau, Alejandro José Salinas, James S. Kaufman, Daniel E. Weiner, Madeleine K. Scammell, Michael D. McClean, Daniel R. Brooks, David J. FriedmanRationale &ObjectiveMesoamerican nephropathy (MeN), a form of chronic kidney disease (CKD) of unknown cause in Central America, affects young individuals working in physically strenuous occupations. Repeated episodes of work-related kidney injury may lead to CKD in this setting. We aimed to better understand the burden and natural history of acute kidney injury (AKI) in workers at risk for MeN.Study DesignCross-sectional study of active sugarcane workers, followed by prospective follow-up of individuals with AKI.Setting &Participants326 sugarcane workers with normal preharvest serum creatinine (Scr) values and no history of CKD in an MeN hotspot in Nicaragua near the end of the harvest, and prospective follow-up of workers with AKI.PredictorAKI during the harvest, as defined by Scr level increase ≥ 0.3 mg/dL over baseline to a level ≥ 1.3 mg/dL.OutcomesKidney function trajectory and development of CKD over 12 months.Analytical ApproachLinear regression models were used to analyze the association between job catego...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research

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Publication date: Available online 17 July 2018Source: Pharmacological ResearchAuthor(s): Omar Emiliano Aparicio-Trejo, Edilia Tapia, Laura Gabriela Sánchez-Lozada, José Pedraza-ChaverriAbstractNowadays, chronic kidney disease (CKD) is considered a worldwide public health problem. CKD is a term used to describe a set of pathologies that structurally and functionally affect the kidney, it is mostly characterized by the progressive loss of kidney function. Current therapeutic approaches are insufficient to avoid the development of this disease, which highlights the necessity of developing new strategies to reve...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
ConclusionIn patients admitted for AHF without renal failure or CKD, WRF with HC is associated with a better prognosis, similar to that of patients without WRF, and should therefore be reclassified as ‘pseudo-WRF’.ResumoIntroduçãoAlterações na função renal com aumento da creatinina têm sido associadas a maior mortalidade em doentes com insuficiência cardíaca aguda (ICA). Já a hemoconcentração na ICA tem-se associado a redução da mortalidade, é também uma causa de elevação da creatinina. Av...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
This study investigated the association between systemic inflammation and chronic kidney disease (CKD), and whether this association changes with aging in adults, by using neutrophil-to-lymphocyte ratio (NLR) as an inflammation marker.Materials and methodsA total of 2954 adults (1815 men and 1139 women) who attended a health examination at a medical center in central Taiwan were included for the final cross-sectional analysis.ResultsCompared with participants aged
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Publication date: Available online 3 November 2017Source: Clinica Chimica ActaAuthor(s): Sahapab Anuwatmatee, Shudi Tang, Ben J. Wu, Kerry-Anne Rye, Kwok Leung OngAbstractThe association between fibroblast growth factor 21 (FGF21) and kidney function has been extensively studied in recent years in both animal and human studies. However, the exact functional role of FGF21 in the kidney remains unclear. Previous animal studies have shown that administration of FGF21 ameliorates kidney function, morphological glomerular abnormalities, dyslipidemia, hyperglycemia, insulin resistance, oxidative stress and obesity. In human stud...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Authors: Patel J, Bridgeman MB Abstract Etelcalcetide (Parsabiv) for hyperparathyroidism in adults with chronic kidney disease on hemodialysis. PMID: 30013296 [PubMed]
Source: P and T - Category: Drugs & Pharmacology Tags: P T Source Type: research
Conclusions: The results of our study point towards a link between CXCL12 and LVH as well as blood pressure control among patients with CKD, supporting the thesis that CXCL12 may be regarded as a new potential uremic toxin.Cardiorenal Med 2018;8:249 –258
Source: Cardiorenal Medicine - Category: Urology & Nephrology Source Type: research
Authors: Lu CC, Ma KL, Ruan XZ, Liu BC Abstract Considerable interest nowadays has focused on gut microbiota owing to their pleiotropic roles in human health and diseases. This intestinal community can arouse a variety of activities in the host and function as "a microbial organ" by generating bioactive metabolites and participating in a series of metabolism-dependent pathways. Alternations in the composition of gut microbiota, referred to as intestinal dysbiosis, are reportedly associated with several diseases, especially diabetes mellitus and its complications. Here we focus on the relationship between ...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Contributors : Victoria L Halperin Kuhns ; Jennifer L PluznickSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity is a significant risk factor for both chronic kidney disease and end-stage renal disease. To better understand disease development, we sought to identify novel genes differentially expressed early in disease progression. We first confirmed that mice fed a high-fat (HF) diet exhibit early signs of renal injury including hyperfiltration. We then performed RNA-Seq using renal cortex RNA from C57BL6/J male mice fed either HF or control (Ctrl) diet. We identified 1,134 gene...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
We report a case of a TAVI in an 80-year-old patient with severe AS and significant chronic kidney disease (CKD), which was carried out without the use of contrast and with minimal procedural hypotension.Pre-procedural imaging was carried out using 3D trans-esophageal echocardiography (TEE) rather than computed tomography (CT) to avoid contrast administration. The Lotus valve (Boston Scientific, Marlborough, MA, USA) was chosen due to a number of design features which minimize both the need for contrast injection and procedural hypotension during valve positioning and deployment. The procedure was carried out successfully ...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
AbstractManagement of hyperphosphatemia in patients with dialysis-dependent chronic kidney disease remains a major challenge, requiring a multifaceted approach that includes dietary phosphate restriction, dialysis, and phosphate binders. However, these treatments fail to meet serum phosphate targets in many patients, potentially further exacerbating the significant morbidity and mortality burden associated with the disease. Recent advances in our understanding of the mechanisms underlying phosphate homeostasis have shed new light on the issue and suggest that gastrointestinal transport proteins may be promising targets for...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
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