Acute Kidney Injury in Sugarcane Workers at Risk for Mesoamerican Nephropathy

Publication date: Available online 2 July 2018Source: American Journal of Kidney DiseasesAuthor(s): Joseph Kupferman, Oriana Ramírez-Rubio, Juan José Amador, Damaris López-Pilarte, Elissa H. Wilker, Rebecca L. Laws, Caryn Sennett, Ninoska Violeta Robles, Jorge Luis Lau, Alejandro José Salinas, James S. Kaufman, Daniel E. Weiner, Madeleine K. Scammell, Michael D. McClean, Daniel R. Brooks, David J. FriedmanRationale &ObjectiveMesoamerican nephropathy (MeN), a form of chronic kidney disease (CKD) of unknown cause in Central America, affects young individuals working in physically strenuous occupations. Repeated episodes of work-related kidney injury may lead to CKD in this setting. We aimed to better understand the burden and natural history of acute kidney injury (AKI) in workers at risk for MeN.Study DesignCross-sectional study of active sugarcane workers, followed by prospective follow-up of individuals with AKI.Setting &Participants326 sugarcane workers with normal preharvest serum creatinine (Scr) values and no history of CKD in an MeN hotspot in Nicaragua near the end of the harvest, and prospective follow-up of workers with AKI.PredictorAKI during the harvest, as defined by Scr level increase ≥ 0.3 mg/dL over baseline to a level ≥ 1.3 mg/dL.OutcomesKidney function trajectory and development of CKD over 12 months.Analytical ApproachLinear regression models were used to analyze the association between job catego...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research

Related Links:

Conclusions: Uremic patients show an enhanced expression of serum miR-421 as compared to healthy individuals. A strong association of circulating miR-421 with decreased transcripts of ACE2 may contribute to the low expression of the enzyme in leukocytes of CKD patients, further supporting the development of atherosclerotic events.Nephron
Source: Nephron - Category: Urology & Nephrology Source Type: research
Authors: Gutiérrez Sánchez D, Leiva-Santos JP, Macías López MJ, Cuesta-Vargas AI PMID: 30316480 [PubMed - in process]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
We describe a novel physiologically-relevant genomic mouse model of APOL1-associated renal disease that expresses human APOL1 from the endogenous human promoter, resulting in expression in similar tissues and at similar relative levels as humans. While naïve genomic APOL1 transgenic mice did not e xhibit a renal disease phenotype, a single administration of IFNγ was sufficient to robustly induce proteinuria only in APOL1 G1 transgenic mice, despite inducing kidney APOL1 expression in both G0 and G1 mice, serving as a clinically-relevant “second hit.” We also report on the discovery of th e first APOL...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
aoping Zhao Flower of Abelmoschus manihot (FAM) is clinically effective to treat chronic kidney disease (CKD) with a relatively high dosage. To improve the efficacy and the compliance of patients, macroporous resins were adopted to enrich and purify flavonoids from FAM, which are thought to be the major renal protective constituents in FAM. After screening six different kinds of macroporous resins, HPD-100 was selected for its great adsorption and desorption capacity. Then, orthogonal design tests were used to optimize parameters in the processes of impurity removal and flavonoids of FAM desorption on column chromatogr...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Abstract Urologic causes of end-stage renal disease are estimated between 25% and 40% of causes. The goal of renal transplantation in chronic kidney disease patients is to provide renal replacement therapy with less morbidity, better quality of life, and improved overall survival compared with dialysis. A patient's urologic history can be a significant source of problems related to infections, recurrence of disease, and surgical complications. Many of the urologic risks are modifiable. Proper evaluation and management can mitigate the potential problems after transplantation, and these patients with complex urolog...
Source: The Urologic Clinics of North America - Category: Urology & Nephrology Authors: Tags: Urol Clin North Am Source Type: research
Conditions:   Chronic Kidney Diseases;   Cardiomyopathies;   Cardiovascular Diseases;   Cardiac Disease Intervention:   Diagnostic Test: Cardiac MRI and contrast-enhanced cardiac CT Sponsor:   NHS Greater Glasgow and Clyde Not yet recruiting
Source: - Category: Research Source Type: clinical trials
AbstractPurposeElective hip or knee replacement is an optimal, standardised orthopaedic surgical procedure. The influence of chronic kidney disease, defined as an estimated glomerular filtration rate (eGFR) of 15 –45 ml/min/1.73 m2 body surface area (BSA) (KDIGO stage G3a-G4), on the duration of hospitalisation, perioperative decrease in haemoglobin (Hb) levels, and transfusion rates after orthopaedic procedures has not been fully clarified. Our study, therefore, aimed to evaluate the impact of chronic kidney disease on the previously mentioned variables.MethodsWe conducted a retrospective multicentre analy...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
AbstractPurposeThe aim of the current study was to evaluate the association between a decreased estimated glomerular filtration rate (eGFR) and accidental falling in elderly patients who visited the day clinic of the department of geriatric medicine of the University of Medical Center Utrecht (UMCU).Study designA cross-sectional analysis with people aged ≥ 65 years of the Utrecht Cardiovascular Cohort was performed. Patients were stratified into different stages of kidney disease (
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
In a case-control study of over 5600 adults from Taiwan published in this month's Journal of Cardiac Failure, Liu and colleagues observed that individuals diagnosed with HF within the past two years were at significantly elevated risk for suicide, even when accounting for physical problems, psychiatric illness, and other suicide risk factors.1 Furthermore, diabetes mellitus, chronic kidney disease, cerebrovascular disease, and cancer were associated with an increased risk of suicide in adjusted analyses.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
“Who in the world am I? Ah, that's the great puzzle”(Lewis Carroll)
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
More News: Chronic Kidney Disease | Legislation | Nicaragua Health | Study | Urology & Nephrology