Methotrexate causes persistent deficits in memory and executive function in a juvenile animal model.
In conclusion, our study demonstrated that a clinically relevant regimen of systemic and intrathecal methotrexate induces persistent deficits in spatial pattern memory, visual recognition memory and executive function, lasting at least 8 weeks after the last injection. The mechanisms behind methotrexate-induced deficits are likely multifactorial and may relate to suppression of neurogenesis, alterations in neuroinflammation and microglial activation, and structural changes in the corpus callosum.
PMID: 29990472 [PubMed - as supplied by publisher]
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Wen J, Maxwell RR, Wolf AJ, Spira M, Gulinello ME, Cole PD Tags: Neuropharmacology Source Type: research
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