GAFFI: Report on Global Fungal Infection Forum III

GAFFI: Report on Global Fungal Infection Forum IIITue, 07/10/2018 - 15:50News blog
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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CONCLUSION: We found that multiplex real-time PCR assay is more accurate than blood culture in detecting fungal species and the results are prepared sooner. Among all factors, only type of cancer (AML) and sever neutropenia, were found to be risk factors for development of fungal infections in all hematologic cancer patients and previous IFI was a risk factor only AML patients. PMID: 30747087 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Endocrinology Authors: Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
The risk of Pneumocystis pneumonia often warrants antifungal prophylaxis for bone marrow and solid organ transplantation patients. However, complications such as myelosuppression, nephrotoxicity, and intolerance with the existing standard, TMP/SMX, may hinder or interrupt prophylaxis.Rezafungin (RZF) is a novel echinocandin in development for prevention of invasive fungal infections caused by Candida, Aspergillus, and Pneumocystis species in patients at high risk of infection. RZF has a favorable safety and tolerability profile and a low risk of drug-drug interactions.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 549 Source Type: research
Rezafungin (RZF) is a novel echinocandin in development for prevention of invasive fungal infections caused by Candida, Aspergillus, and Pneumocystis spp. in patients at high risk of infection. RZF has demonstrated in vivo prophylaxis efficacy and low risk of drug-drug interactions. Furthermore, the stability and PK profile of RZF allow for once-weekly dosing.RZF is also in development for treatment of candidemia and invasive candidiasis using a dosing regimen of RZF 400 mg followed by 200 mg once-weekly, which achieved>90% target attainment against Candida.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 537 Source Type: research
Fungal diseases are significant causes of mortality and morbidity in both the developed and the developing world. The recent increases in the incidence and severity of invasive fungal infections are directly attributable to new susceptible patient populations. Examples of these large, at-risk populations include patients with AIDS; hospitalized patients being treated for cancer and autoimmune disorders; andthose receiving organ transplants.Courses&Workshops
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Publication date: Available online 4 December 2018Source: The Journal of Molecular DiagnosticsAuthor(s): Ling-Shan Yu, Jesus Rodriguez-Manzano, Kenny Malpartida-Cardenas, Thomas Sewell, Oliver Bader, Darius Armstrong-James, Matthew C. Fisher, Pantelis GeorgiouInvasive fungal infections caused by multiazole-resistant Aspergillus fumigatus are associated with increasing rates of mortality in susceptible patients. Current methods of diagnosing infections caused by multiazole-resistant A. fumigatus are, however, not well suited for use in clinical point-of-care testing or in the field. Loop-mediated isothermal amplification (L...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
Publication date: Available online 10 January 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Virginia Sara Grancieri do Amaral, Caroline Mota Fernandes, Mário R. Felício, Aline Sol Valle, Paula G. Quintana, Caroline Correa de Almeida, Eliana Barreto-Bergter, Sónia Gonçalves, Nuno C. Santos, Eleonora KurtenbachAbstractPsd2 is a pea defensin with 47 amino acid residues that inhibits the growth of fungal species by an uncharacterized mechanism. In this work, Psd2 interactions with model membranes mimicking the lipid compositions of different organisms were evaluated. Prote...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Authors: Kunitomi A, Hasegawa Y, Hashimoto H, Saito AM, Iida H Abstract Invasive fungal infections, especially those caused by Aspergillus, can be fatal in patients who have undergone allogeneic hematopoietic stem cell transplantation. Fluconazole, itraconazole and micafungin can be used to prevent fungal infections in patients undergoing allogeneic hematopoietic stem cell transplantation, but fluconazole is not effective against Aspergillus, and itraconazole has less tolerability from gastrointestinal toxicity. Micafungin is approved for prophylaxis at a dose of 50 mg/day, less than a therapeutic dose. Voriconazol...
Source: Nagoya Journal of Medical Science - Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research
In this study the localization and antifungal activity of the lung surfactant protein D (SP-D) was studied in an environment mimicking the lung lining. To this end Calu-3 cells were grown on an air-liquid interface allowing them to polarize and to produce mucus at their apical surface. Additionally, neutrophils were added to study their role in fungal clearance. Two fungal pathogens were used for these experiments: Candida albicans and Aspergillus fumigatus, both of clinical relevance. During fungal infection SP-D localized strongly to both fungal surfaces and stayed bound through the different stages of infection. Further...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Authors: Hagiwara D Abstract Aspergillus fumigatus is a saprophytic fungus that is a major causative pathogen for aspergillosis. Only a few classes of antifungals are used for treating this life-threatening fungal infection. Azoles are the first-line drugs and are widely used for the management and prophylaxis of aspergillosis. An emerging issue is the increasing incidence of resistant isolates worldwide. In particular, environmentally derived tandem-repeat-type azole-resistant mutations, such as Cyp51A TR34/L98H, and Cyp51A TR46/Y121F/T289A, have emerged over the last decade. In particular, azole-resistant isolate...
Source: Medical Mycology Journal - Category: Biology Tags: Med Mycol J Source Type: research
Publication date: Available online 4 December 2018Source: The Journal of Molecular DiagnosticsAuthor(s): Ling-Shan Yu, Jesus Rodriguez-Manzano, Kenny Malpartida-Cardenas, Thomas Sewell, Oliver Bader, Darius Armstrong-James, Matthew C. Fisher, Pantelis GeorgiouAbstractInvasive human fungal infections caused by multi-azole resistant Aspergillus fumigatus are associated with increasing rates of mortality in susceptible patients. Current methods of diagnosing infections caused by multi-azole resistant A. fumigatus are, however, not well suited for use in clinical point-of-care testing or in the field. Loop-mediated isothermal ...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
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