Mangiferin inhibits High-Fat Diet induced vascular injury via regulation of PTEN/AKT/eNOS pathway

Publication date: Available online 10 July 2018Source: Journal of Pharmacological SciencesAuthor(s): Jiang Fang, Zhang De-long, Jia Min, Hao Wei-hua, Li Yong-junAbstractMangiferin (MAN), a naturally occurring polyphenol commonly found in mango and papaya. However, little is known its anti-vascular injury effects and the underlying mechanisms. This paper investigated the anti-vascular injury effect of MAN and the mechanisms in high-fat diet (HFD)-induced C57BL/6J mice and oxidized low-density lipoprotein (ox-LDL) induced human umbilical vein endothelial cells (HUVECs). The levels of plasma lipid, inflammatory factors and nitric oxide (NO) in mice were evaluated. The expression levels of PI3K, AKT, eNOS, PTEN and their phosphorylated proteins were measured by western blots. In addition, the PTEN-siRNA HUVECs were also used. The result showed that MAN markedly decreased the plasma lipid, inflammatory level in HFD-induced vascular injury mice respectively. Furthermore, MAN alleviate ox-LDL-stimulated dysfunction of HUVECs, restored the diminished NO release, decreased the ROS generation, significantly increased the expression of p-Akt, p-eNOS, and decreased the expression of PTEN, but have no effect on PI3K. However, the protective effects of MAN were significantly reduced by co-treatment with PI3K inhibitor or abolished by eNOS inhibitor. In addition, MAN has no protective effect on ox-LDL induced PTEN-siRNA HUVECs injury. Collectively, MAN appeared to alleviate ox-LDL-stimulate...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research

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Authors: Błaszczyk B, Miziak B, Czuczwar P, Wierzchowska-Cioch E, Pluta R, Czuczwar SJ Abstract INTRODUCTION: Considering that there are around 30% of patients with epilepsy resistant to monotherapy, the use of synergistic combinations of antiepileptic drugs is of particular importance. This review shows most beneficial as well as irrational combined treatments both from an experimental and clinical point of view. Areas covered: Preferably, experimental data derived from studies evaluating synergy, additivity or antagonism by relevant methods, in terms of anticonvulsant or neurotoxic effects and pharmacokinetic da...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
STOMACH bloating causes can include allergy to a particular food, eating too quickly or consuming a product which leads to gas release and causes a bloated stomach. Eating products containing this sweetener could cause stomach bloating.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ConclusionThe study is a prospective observational cohort study specifically designed to assess the impact of EEG-fMRI on the clinical decision making process, suggesting a significant influence of EEG-fMRI on epilepsy surgery planning.
Source: Seizure - Category: Neurology Source Type: research
This report describes three cases of acute liver injury following pulse corticosteroid therapy with reference to other possible causative factors. Caution should be exercised when applying high-dose methylprednisolone given the potential liver related adverse events it may cause.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: October 2018Source: Multiple Sclerosis and Related Disorders, Volume 25Author(s): Mark Cascione, Nadia Tenenbaum, Jeanette Wendt, Xiangyi Meng, Lesley Schofield, Bruce A.C. Cree, PREFERMS investigatorsAbstractBackgroundSuboptimal persistence with injectable disease-modifying therapies (iDMTs; interferon beta-1a/b, glatiramer acetate) is common in patients with relapsing forms of multiple sclerosis (MS), reducing the effectiveness of these agents. Adherence to, and persistence with, an effective therapy is important for patient populations at increased risk of rapid disease progression. African-American in...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionsRecurrent vaginitis should be taken into account as a possible adverse effect causing discomfort during long-term natalizumab treatment. Simple measures, such as probiotic administration and meticulous local hygiene, can provide adequate relief for such patients.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 20 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Gareth Pryce, David BakerAbstractSince their discovery, the existence of secreted oligoclonal immunoglobulin in the central nervous system in people with multiple sclerosis has been the subject of scientific investigation and debate over several decades. Although autoantibodies can be detected in some individuals, probably secondary to release of neo-antigens after damage, evidence for a major, primary involvement of damaging antibodies is still relatively lacking. However it is possible to construct a working hypothes...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionThis case suggests a manifestation of the proximal PNS in NMOSD. Thus, NMOSD should be considered as a differential diagnosis for patients presenting with signs of spinal cord disease and additional radicular involvement.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 20 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Mario Habek, Tin Pavičić, Berislav Ruška, Ivan Pavlović, Tereza Gabelić, Barbara Barun, Ivan Adamec, Luka Crnošija, Magdalena Krbot SkorićAbstractAimTo compare the sensitivity, specificity and accuracy of the 2010 and 2017 revisions of the McDonald criteria in a Croatian cohort of patients with a clinically isolated syndrome (CIS).MethodsProspectively collected data from 113 patients were retrospectively analyzed. Sensitivity, specificity and accuracy for both criteria were calculated regarding conve...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionsPediatric demyelinating diseases in Brazil are similar to the diseases described abroad. In patients with pMS, the EDSS score at the first appointment and the total number of relapses were associated with poor prognosis. NMOSD is more severe than MS in pediatric patients. Treatment with DMD and azathioprine was well tolerated and effective in reducing relapse rate and disability.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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