DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer.

Conclusion: Our data demonstrate that both DNA and histone modifications are involved in upregulation of PD-1, CTLA-4, TIM-3, and LAG-3 in breast tumor tissue and these epigenetic modifications could be useful as diagnostic/prognostic biomarkers and/or therapeutic targets in breast cancer.
PMID: 29983831 [PubMed - in process]

Source: Clinical Breast Cancer - July 11, 2018 Category: Cancer & Oncology Authors: Sasidharan Nair V, El Salhat H, Taha RZ, John A, Ali BR, Elkord E Tags: Clin Epigenetics Source Type: research