Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma.

Efficacy of a new cancer treatment strategy based on eradication of tumor-initiating stem cells in a mouse model of Krebs-2 solid adenocarcinoma. Oncotarget. 2018 Jun 19;9(47):28486-28499 Authors: Potter EA, Proskurina AS, Ritter GS, Dolgova EV, Nikolin VP, Popova NA, Taranov OS, Efremov YR, Bayborodin SI, Ostanin AA, Chernykh ER, Kolchanov NA, Bogachev SS Abstract Krebs-2 solid carcinoma was cured using a new "3+1" strategy for eradication of Krebs-2 tumor-initiating stem cells. This strategy was based on synchronization of these cells in a treatment-sensitive phase of the cell cycle. The synchronization mechanism, subsequent destruction of Krebs-2 tumor-initiating stem cells, and cure of mice from a solid graft were found to depend on the temporal profile of the interstrand cross-link repair cycle. Also, the temporal profile of the Krebs-2 interstrand repair cycle was found to have a pronounced seasonal cyclicity at the place of experiments (Novosibirsk, Russia). As a result, the therapeutic effect that is based on application of the described strategy, originally developed for the "winter repair cycle" (November-April), is completely eliminated in the summer period (June-September). We conclude that оne of the possible and the likeliest reasons for our failure to observe the therapeutic effects was the seasonal cyclicity in the duration of the interstrand repair cycle, the parameter that is central to our strategy. PMID: 299838...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research

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Publication date: Available online 18 January 2019Source: Inorganic Chemistry CommunicationsAuthor(s): Yi-Dong Bin, Yan Yang, Xu-Jian Luo, Hua-Xin ZhangAbstractA novel Pt(II) complex of [PtII(MPP)(OPD)]Cl⋅H2O (MPP-Pt) (OPD = o-phenylenediamine) with 2-(2,5-methoxy-phenyl) imidazo [4,5-f]-[1, 10] phenanthrolin (H-MPP) was synthesized and fully characterized. In MPP-Pt complex, the Pt(II) ion adopts a four-coordinated square planar geometry. MPP-Pt exhibited selective cytotoxicity against human carcinoma (A549), hepatoblastoma (Hep-G2), ovarian (SK-OV-3), cervical (HeLa) and gastric adenocarcinoma (MGC80–3) ce...
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
Publication date: Available online 11 January 2019Source: European Journal of Surgical OncologyAuthor(s): Min Yang, Yi Zhang, Lin Zeng, Neng-wen Ke, Chun-lu Tan, Bo-le Tian, Bo Xiang, Xu-bao LiuAbstractBackground and objectiveWe aimed to compare the two new defined tumor-node-metastasis (TNM) systems in the American Joint Committee on Cancer (AJCC) 8th staging manual for overall survival (OS) analysis of G3 pancreatic neuroendocrine carcinomas (p-NECs) that are currently proposed for pancreatic exocrine adenocarcinomas (p-EACs) and G1/G2 pancreatic neuroendocrine tumors (p-NETs), respectively.MethodsThe data of patients wh...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
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Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
AbstractAcquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors remains the main hurdle in treating EGFR-mutated lung cancer. Besides, when leptomeningeal carcinomatosis occurs during treatment, it often leads to treatment failure. We herein report a case of lung adenocarcinoma involving a patient with an EGFR exon 19 deletion mutation who developed leptomeningeal carcinomatosis after afatinib treatment for post-operative recurrence. He received right lower lobectomy, followed by four cycles of cisplatin and pemetrexed treatment. Follow-up CT/MRI revealed multiple pulmonary metastases and brain m...
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
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Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
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Source: Gastric Cancer - Category: Gastroenterology Source Type: research
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Source: Journal of Cytology - Category: Cytology Authors: Source Type: research
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Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
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Source: Neurochirurgie - Category: Neurosurgery Tags: Neurochirurgie Source Type: research
Conditions:   Castration Levels of Testosterone;   Castration-Resistant Prostate Carcinoma;   Metastatic Prostate Carcinoma;   Prostate Adenocarcinoma;   Stage IV Prostate Cancer AJCC v8;   Stage IVA Prostate Cancer AJCC v8;   Stage IVB Prostate Cancer AJCC v8 Interventions:   Drug: Lutetium Lu 177-PSMA-617;   Biological: Pembrolizumab Sponsors:   University of California, San Francisco;   National Cancer I...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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