Beta-carotene-bound albumin nanoparticles modified with chlorin e6 for breast tumor ablation based on photodynamic therapy

Publication date: Available online 10 July 2018Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Pham Thi Thu Phuong, Sungin Lee, Changkyu Lee, Bohyung Seo, Sanghyun Park, Kyung Taek Oh, Eun Seong Lee, Han-Gon Choi, Beom Soo Shin, Yu Seok YounAbstractChlorin e6 (Ce6) has attracted considerable interest as a promising second-generation photosensitizer for photodynamic therapy (PDT). However, the in vivo availability of Ce6 is significantly restricted by its low water solubility and poor ability to target tumors. We sought to overcome the limitations of Ce6 by using albumin nanoparticles with nabTM (nanoparticle albumin-bound) technology. The fabricated albumin nanoparticles consisted of bovine serum albumin (BSA), Ce6-BSA, and beta-carotene as a carrier, photosensitizing agent, and cross-linker, respectively. These albumin nanoparticles (Ce6-BSA-BC-NPs) did not include any toxic chemotherapeutics but instead contained naturally safe beta-carotene and Ce6, which was activated only upon irradiation with 660-nm laser light. Ce6-BSA-BC-NPs were ~120 nm in size and spherical, similar to Abraxane®, and showed good physicochemical stability. The nanoparticles showed significant cytotoxicity toward 4T1 cells as evaluated by MTT, Live/Dead, and TUNEL assays. In particular, results of the TUNEL assay demonstrated that cell death induced by Ce6-BSA-BC-NPs and light irradiation (660 nm) occurred through the apoptotic pathway. Ce6-BSA-BC-NPs displayed a remarkably enhanced t...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research

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Publication date: Available online 23 May 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Andrei Sakai, Ana Paula de Sousa Mesquista, Erica Valadares de Castro Levatti, Anita Hilda Straus, Helena B. Nader, Carla Cristina Lopes, Luciano CaseliAbstractTrastuzumab (Tmab) is a monoclonal antibody administered as targeted therapy for HER2-positive breast cancer whose molecular interactions at the HER2 receptor microenvironment are not completely clarified yet. This paper describes the influence of Tmab in the molecular organization of films of biological-relevant molecules at the air water interface. Fo...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
Authors: Mayrovitz H Abstract Obesity is linked to the risk of breast cancer and treatment-related lymphedema (BCRL). Thus, knowledge of how obesity, or more specifically total body fat percentage (TBF) and body mass index (BMI), affect measurements that are used to detect or track lymphedema is clinically important. Tissue dielectric constant (TDC) is one measure used to help characterize lymphedema features, detect its presence, and assess treatment-related changes. The goal of this research was to determine the extent to which TDC values depend on TBF and BMI. TDC was measured on both forearms (2.5mm depth) in 2...
Source: Lymphology - Category: Internal Medicine Tags: Lymphology Source Type: research
This study aimed to establish diagnostic accuracy of interlimb differences of ultrasonographic subcutaneous tissue thickness measurements in breast cancer-related arm lymphedema. We compared the truncated cone method by using circumference measurements and interlimb differences of ultrasonographic subcutaneous tissue thickness measurements to evaluate the diagnostic accuracy of interlimb differences of ultrasonographic subcutaneous tissue thickness measurements. Sensitivity, specificity, receiver-operating characteristic (ROC) curve, and area under the curve (AUC) were used. Analysis of ROC curves yielded area under the cu...
Source: Lymphology - Category: Internal Medicine Tags: Lymphology Source Type: research
The FDA approved alpelisib (Piqray, Novartis) to be used with the FDA-approved fulvestrant in certain patients with breast cancer. A companion test was also approved.FDA Approvals
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news
ConclusionsThe investigative team developed a novel breast cancer treatment DA that is acceptable to women ≥70 years with a history of ER+, HER2-, early stage breast cancer. Next, the DA's efficacy needs to be tested with diverse older women newly diagnosed with breast cancer.
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
The U.S. Food and Drug Administration (FDA) said on Friday that it had approved Novartis AG's treatment in combination with a hormone therapy for postmenopausal women, as well as for men, with a form of advanced breast cancer.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Breast cancer detection is similar with digital breast tomosynthesis (DBT) or standard digital mammography, though DBT may reduce recall rates, researchers say.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
ConclusionThe results suggest that Ca3(PO4)2:Tb3+, Ce3+ phosphor may be useful for therapeutic application in clinical settings.Graphical abstract
Source: IRBM - Category: Biomedical Engineering Source Type: research
Condition:   Estrogen Receptor-positive Breast Cancer Interventions:   Dietary Supplement: 2-Week Ketogenic Diet;   Drug: Letrozole Sponsor:   Vanderbilt-Ingram Cancer Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Sun W, Shen NM, Fu SL Abstract Cervical cancer (CC) develops, after human papillomavirus (HPV), an infection transmitted through sexual contact. Worldwide estimates are around>500,000 CC diagnoses and>300,000 related deaths annually, and CC remains the second most devastating type of cancers in women after breast cancer. Although the vaccine against HPV has reduced the incidence of infection and the treatment efficacy of the early-stage diagnoses has improved, many challenges remain in terms of treatment efficacy, during the late-stage and prevention of chemotherapy resistance development. Thus, new ...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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