Hyaluronan magnetic nanoparticle for mitoxantrone delivery toward CD44-positive cancer cells

Publication date: Available online 11 July 2018Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Azam Sargazi, Fereshteh Shiri, Sheida Keikha, Mostafa Heidari MajdAbstractHyaluronic acid (HA) is increasingly investigated for biomedical applications such as regenerative medicine, aesthetic medicine, and drug delivery. Accordingly, conjugation of HA to PEGylated MNPs could increase the active targeting ability of nano-drug carriers toward CD44 receptors and be useful in a clinical setting such as drug delivery. So, we chemically conjugated mitoxantrone (MTX) to HA-PEGylated MNPs to use concurrent advantages such as prolong the circulation time, decrease the side effects and delivery toward special tumor cells. Size of the Fe3O4-DPA-PEG-HA-MTX NPs was determined ~200 nm utilizing FESEM and DLS. Stability analysis confirmed that prepared MNPs were stable in physiological conditions even after 8 days and only 47.3% of MTX was liberated from nanocarriers, in the event that, acidic condition and also presence of protease enzyme accelerated the amount of MTX release to 100% after 8 days of incubation. The in vitro cytotoxicity analysis by MTT assay revealed that viable cell numbers were reduced by 32% when MTX-HA-MNPs were applied against MDA-MB-231 cell lines, while they showed significant decreased cellular cytotoxic effects on cell viability in the MCF-7 cell lines which express lower levels of CD44 receptor at the cell surface. Also, results of flow cytometry analysis fo...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research

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Publication date: Available online 24 May 2019Source: Veterinary MicrobiologyAuthor(s): Sante Roperto, Valeria Russo, Francesca De Falco, Alessandra Rosati, Cornel Catoi, Franco RopertoAbstractE5 protein, the major oncoprotein of the bovine Deltapapillomavirus genus, has been detected in 17 of the 19 urothelial cancers by molecular and morphological procedures. In 10 urothelial cancers, the oxygen sensitive subunit HIF-1α, which is upregulated by hypoxia, was overexpressed. Mitophagy, the selective autophagic removal of dysfunctional mitochondria, was upregulated in hypoxic neoplastic cells infected by BPVs which was...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Conclusion: Formal consensus was achieved for the first time on a core list of knowledge items on how exercises and physical activities might stimulate anticancer immunity. This core list might be considered at the time of developing training/educational interventions and/or continuing education for primary healthcare providers and CAM practitioners. Future studies are still needed to investigate if such consensual lists might improve congruence in cancer care continuum and improve survival rates and wellbeing of cancer patients and survivors. PMID: 31118968 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Oei SL, Thronicke A, Schad F Abstract In early tumor development, cancer cells develop a plethora of strategies to escape surveillance from the adaptive and innate immune system. Cancer immunotherapies, in particular immune checkpoint inhibitors, are becoming a highly promising cancer therapeutic approach that has remarkable increased progress in combating various cancer types. Unfortunately, their mechanisms of action induce some complications, such as inflammatory reactions and immune-related adverse events. In the management of side effects during anticancer therapy, complementary and integrative therap...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 25 May 2019Source: Biosensors and BioelectronicsAuthor(s): Shao Su, Qian Sun, Ling Wan, Xiaodan Gu, Dan Zhu, Yi Zhou, Jie Chao, Lianhui WangAbstractUltrasensitive detection of cancer biomarkers has shown great promise for precision medicine. Here, a triple signal amplification strategy was developed for analysis of carcinoembryonic antigen (CEA) by using MoS2-based nanocomposites. Gold nanoparticles-decorated molybdenum disulfide nanocomposite (MoS2-AuNPs) was used to construct the modified electrode and nanoprobe, which could efficiently amplify electrochemical signal due to its large su...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 24 May 2019Source: Molecular Aspects of MedicineAuthor(s): Ester Saus, Susana Iraola-Guzmán, Jesse R. Willis, Anna Brunet-Vega, Toni GabaldónAbstractThe gastrointestinal tract harbors most of the microbiota associated with humans. In recent years, there has been a surge of interest in assessing the relationships between the gut microbiota and several gut alterations, including colorectal cancer. Changes in the gut microbiota in patients suffering colorectal cancer suggest a possible role of host-microbe interactions in the origin and development of this malignancy and, at th...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
Soft Matter, 2019, Accepted Manuscript DOI: 10.1039/C9SM00526A, PaperMatteo Campo, Simon Kaspar Schnyder, John Jairo Molina, Thomas Speck, Ryoichi Yamamoto The migration of cells is relevant for processes such as morphogenesis, wound healing, and invasion of cancer cells. In order to move, single cells deform cyclically. However, it is not... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - Category: Chemistry Authors: Source Type: research
Publication date: 25 May 2019Source: New Scientist, Volume 242, Issue 3231Author(s):
Source: New Scientist - Category: Science Source Type: research
Publication date: Available online 25 May 2019Source: Preventive MedicineAuthor(s): Abbey E. Poirier, Yibing Ruan, Lauren A. Hebert, Xin Greversa, Stephen D. Walter, Paul J. Villeneuve, Darren R. Brenner, Christine M. Friedenreich, ComPARe Study Team
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 25 May 2019Source: Preventive MedicineAuthor(s): Christine M. Friedenreich, Amanda M. Barberio, Joy Pader, Abbey E. Poirier, Yibing Ruan, Xin Grevers, Stephen D. Walter, Paul J. Villeneuve, Darren R. Brenner, ComPARe Study Team
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 25 May 2019Source: Preventive MedicineAuthor(s): Xin Grevers, Yibing Ruan, Abbey E. Poirier, Stephen D. Walter, Paul J. Villeneuve, Christine M. Friedenreich, Darren R. Brenner, ComPARe Study Team
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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