Revealing A-Raf functions through its interactome

Publication date: August 2018Source: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Volume 1866, Issue 8Author(s): Xin-Yu Zhang, Hui Guo, Bing Han, Xu-Min Zhang, Ying Huang, Yang Yang, Ying Liu, Xiao-Xi Guo, Qian Hao, Su An, Tian-Rui XuAbstractA-Raf is a member of the Raf kinase family. Unlike B-Raf and C-Raf, the functions of A-Raf remain obscure. To gain more insight into the biological functions of A-Raf, we investigated the A-Raf interactome using proteomics. We found 132 proteins that interact with A-Raf and confirmed the interaction of 12 of these proteins with A-Raf by western blotting. Our data suggested that A-Raf regulates apoptosis, RNA catabolism, GTPase activity, and cell adhesion by interacting with proteins located in different cellular compartments. We identified all ten hallmarks of cancer in these interacting proteins, suggesting that A-Raf is involved in carcinogenesis. Our results also indicated that A-Raf may play a role in different diseases and signaling pathways. These findings have identified potential regulators of A-Raf and provide a systemic insight into its biological functions.
Source: Biochimica et Biophysica Acta (BBA) Proteins and Proteomics - Category: Biochemistry Source Type: research

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CONCLUSIONS: This study demonstrated the increased risk of skin cancer in transplant patients during the first 7 years of follow-up and made the dermatologists aware about the need of a regular cutaneous follow up for this subset of patients. PMID: 30229636 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Authors: Day D, Burgess CM, Kircik LH Abstract BACKGROUND: Melatonin is an endogenous hormone commonly associated with regulation of sleep. However, over the last two decades, research has elucidated a range of effects associated with the compound, including anti-inflammatory, both direct and indirect antioxidant activity, tissue regenerative benefits, and preservation of mitochondrial function. Melatonin's anti-inflammatory and antioxidant support, coupled with its mitochondrial support, make it an intriguing target for use to support skin health. Human skin and hair follicles express functional melatonin receptor...
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Publication date: Available online 20 September 2018Source: Journal of Biomedical InformaticsAuthor(s): Alex Graudenzi, Davide Maspero, Marzia Di Filippo, Marco Gnugnolo, Claudio Isella, Giancarlo Mauri, Enzo Medico, Marco Antoniotti, Chiara DamaniAbstractEffective stratification of cancer patients on the basis of their molecular make-up is a key open challenge. Given the altered and heterogenous nature of cancer metabolism, we here propose to use the overall expression of central carbon metabolism as biomarker to characterize groups of patients with important characteristics, such as response to ad-hoc therapeutic strateg...
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
Publication date: Available online 21 September 2018Source: The Lancet HIVAuthor(s): Silvia Franceschi
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
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Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
Publication date: Available online 19 September 2018Source: Microbial PathogenesisAuthor(s): Govindan Rajivgandhi, Thillaichidambaram Muneeswaran, Muthuchamy Maruthupandy, Kandasamy Saravanan, Vilwanathan Ravikumar, Natesan ManoharanAbstractThe current study aimed to identify bioactive compound from marine endophytic actinomycetes isolated from Gulf of Mannar, southeast coast of India. Among the isolated actinomycetes, strain GRG 4 exhibited excellent ability to inhibit colistin resistant (CR) Pseudomonas aeruginosa and Klebsiella pneumonia, which emerging threat to the world. The strain was identified as Streptomyces coer...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionsThis study has elucidated the genome-wide effects of several adaptogenic herbal extracts in brain cells culture. These data highlight the consistent activation of ASRSPs by adaptogens in T98G neuroglia cells. The extracts affected many genes playing key roles in modulation of adaptive homeostasis, indicating their ability to modify gene expression to prevent stress-induced and aging-related disorders. Overall, this study provides a comprehensive look at the molecular mechanisms by which adaptogens exerts stress-protective effects.Graphycal abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
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Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
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