Cancer-specific pro-oxidant therapy using low-toxic polypeptide micelles encapsulating piperlongumine

This study demonstrates that PL-PEG-poly(His) micelles are efficient and low-toxic carriers for PL delivery, thus leading to effective and cancer-targeted pro-oxidant therapy.Graphical abstractPEG-poly(His) micelles encapsulating pro-oxidant piperlongumine were prepared and exhibited cancer-specific cytotoxicity via elevated ROS accumulation in cancer cells.
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research