10. Comprehensive genomic characterization of pediatric B-ALL

B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. Genomic alterations in B-ALL are essential for disease diagnosis, prognosis, and treatment. We performed integrated genomic analysis on 136 pediatric B-ALL patients using the CHOP Comprehensive Hematological Cancer NGS Panel along with conventional cytogenetic studies. The panel interrogates 118 cancer genes for sequence and copy number variants (CNV) and 110 genes for known and novel fusions. Clinically significant genomic changes were identified in 89.7% of patients.

Source: Cancer Genetics and Cytogenetics - July 11, 2018 Category: Genetics & Stem Cells Authors: Minjie Luo, Fumin Lin, Xiaonan Zhao, Junxia Tang, Gozde T. Akgumus, Daniel J. Gallo, Edward Romasko, Adam G. Gleason, Lea F. Surrey, Gerald Wertheim, Marilyn M. Li Source Type: research