Metastatic Squamous Cell Carcinoma of Known and Unknown Primary Origin Treated with Axillary or Inguinal Lymphadenectomy

ConclusionsNearly two-thirds of patients undergoing axillary or inguinal lymphadenectomy for metastatic SCC of unknown primary were alive five years following the procedure.
Source: The American Journal of Surgery - Category: Surgery Source Type: research

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ConclusionsWith no emergence of putative primaries and no isolated contralateral neck failures, this single‐institution experience in p16/HPV‐positive SCCUP patients suggests that unilateral radiotherapy may be an underutilized management strategy. Levels of Evidence4 Laryngoscope, 2018
Source: The Laryngoscope - Category: ENT & OMF Authors: Tags: Head and Neck Source Type: research
Abstract BackgroundTreatment for squamous cell carcinoma (SCC) of unknown primary consists of radiotherapy (RT) +/‐ chemotherapy or neck dissection +/‐ adjuvant RT/chemoradiotherapy (CRT). We compared these strategies and identified prognostic factors. MethodsFrom 1993 to 2015, 75 patients with SCC of unknown primary had RT‐based or surgery‐based treatment. Primary endpoints were overall survival (OS) and disease‐free survival (DFS). Event‐time distributions were estimated using the Kaplan‐Meier method. ResultsFive‐year OS and DFS for RT‐based and surgery‐based treatments were similar (OS 73% vs 68%, re...
Source: Head and Neck - Category: ENT & OMF Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionOropharynx‐directed, ipsilateral radiation results in disease control that compares favorably with historical controls treated by comprehensive mucosal and bilateral neck radiation.
Source: Head and Neck - Category: ENT & OMF Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionsOccult head and neck primaries present a diagnostic challenge that is not adequately overcome using traditional detection protocols. The current study presents our unique protocol at Dalhousie University, which demonstrates the efficacy of the PET‐CT TLM protocol from both a detection and therapeutic perspective. Level of Evidence4. Laryngoscope, 2017
Source: The Laryngoscope - Category: ENT & OMF Authors: Tags: Head and Neck Source Type: research
Combined 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography (PET)/computed tomography (CT) has an established role in the staging of difficult cases of head and neck (HN) squamous cell carcinoma (SCC), looking for an unknown primary, assessing response post-chemotherapy at 3 –6 months, and differentiating relapse from treatment effects in patients suspected to have tumour recurrence. The PET NECK trial, comparing PET/CT surveillance versus neck dissection in advanced head and neck cancer showed survival was similar among patients who underwent PET/CT-guided surveillan ce and those who underwent plann...
Source: Clinical Radiology - Category: Radiology Authors: Tags: Review Source Type: research
AbstractThe treatment of patients with cervical lymph node metastases without detectable primary tumor remains an important challenge, until today, no standard therapy is available. The present study investigated the multimodal treatment of patients with head and neck CUP syndrome (HNCUP) and their follow-up retrospectively. 81 patients with cervical lymph node metastases without a primary tumor were treated at the Departments of Otorhinolaryngology as well as Radiotherapy and Radiation Oncology at the University of Saarland in Homburg, Germany in the period between 1991 and 2013. All patients received routine work-up cons...
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
Treatment for squamous cell carcinoma of unknown primary (SCCUP) of the head and neck consists of radiation (RT) +/- chemotherapy (C) or surgery +/- adjuvant RT/CRT. We compared these strategies and identified prognostic factors for disease control and survival.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Poster Source Type: research
CONCLUSION: Unknown primary carcinoma tended to show a poor prognosis. However, when treatment modality of unknown primary carcinoma is to be determined through the prognostic factors, the patients quality of life can be improved through reducing the treatment side effects and economic burden on the patients.
Source: Cancer Research and Treatment - Category: Cancer & Oncology Tags: Original Article Source Type: research
Authors: Mackenzie K, Watson M, Jankowska P, Bhide S, Simo R Abstract This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. It discusses the evidence base pertaining to the management of metastatic neck disease in the setting of an unknown primary and provides recommendations on the work up and management for this group of patients receiving cancer care. Recommendations • All patients presenting with confirmed cervical lymph node metastatic squamous cell carcinoma and no apparent primary site should undergo: ○ Positron emission ...
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research
This cohort study examines the effect of intensity-modulated radiotherapy and chemotherapy in patients with of base-of-tongue squamous cell carcinoma or head and neck carcinoma of unknown primary site.
Source: JAMA Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Source Type: research
More News: Cancer & Oncology | Carcinoma | Carcinoma of Unknown Primary | Chemotherapy | Skin | Skin Cancer | Squamous Cell Carcinoma