Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies: Associations with clinical severity, glucose metabolism and tau PET

Publication date: 2018Source: NeuroImage: Clinical, Volume 19Author(s): Zuzana Nedelska, Matthew L. Senjem, Scott A. Przybelski, Timothy G. Lesnick, Val J. Lowe, Bradley F. Boeve, Arvin Arani, Prashanthi Vemuri, Jonathan Graff-Radford, Tanis J. Ferman, David T. Jones, Rodolfo Savica, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Kejal KantarciAbstractVisually preserved metabolism in posterior cingulate cortex relative to hypometabolism in precuneus and cuneus, the cingulate island sign, is a feature of dementia with Lewy bodies (DLB) on FDG-PET. Lower cingulate island sign ratio (posterior cingulate cortex/cuneus+precuneus; FDG-CISr) values have been associated with a higher Braak neurofibrillary tangle stage in autopsied DLB. Using voxel-wise analysis, we assessed the patterns of regional cortical perfusion and metabolism, and using an atlas-based approach, we measured perfusion cingulate island sign ratio on arterial spin labeling MRI (ASL-CISr), and its associations with FDG-CISr, uptake on tau-PET and clinical severity in DLB. Our study sample (n = 114) included clinically probable DLB patients (n = 19), age-matched patients with probable Alzheimer's disease dementia (AD; n = 19) and matched controls (n = 76) who underwent MRI with 3-dimensional pseudo-continuous arterial spin labeling, 18F-FDG-PET and 18F-AV-1451 tau PET. Patterns of cortical perfusion and metabolism were derived from quantitative maps using Statistical Parametric Mapping. DLB p...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research