The Air Out There: Treatment Planning When Target Volumes Extend Beyond the Skin

A patient presented with squamous cell carcinoma of the vulva, pT2pN2c, stage IIIC status post radical vulvectomy and bilateral groin dissection. The pathology report revealed close and positive margins and lymphovascular space invasion at the primary site, as well as multiple positive lymph nodes with extracapsular extension. The patient was simulated head-first supine in the frog-legged position, with the assistance of a custom immobilization device. Simulation also included 5  mm of water-equivalent bolus applied to the right groin, corresponding to a region suspicious for positive nodes and extracapsular extension.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research

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Publication date: Available online 19 August 2018Source: Pathology - Research and PracticeAuthor(s): Parnian Ahmadi Moghaddam, Rajesh Singh, Mandana Mahmoodi, Meenakshi Mehrotra, Gustavo Benaim, Rajyalakshmi Luthra, Alberto Paniz-Mondolfi
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Authors: Silva VAO, Rosa MN, Tansini A, Oliveira RJS, Martinho O, Lima JP, Pianowski LF, Reis RM Abstract A large number of classic antineoplastic agents are derived from plants. Euphorbia tirucalli L. (Euphorbiaceae) is a subtropical and tropical plant, used in Brazilian folk medicine against many diseases, including cancer, yet little is known about its true anticancer properties. The present study evaluated the antitumor effect of the tetracyclic triterpene alcohol, euphol, the main constituent of E. tirucalli in a panel of 73 human cancer lines from 15 tumor types. The biological effect of euphol in pancreatic ...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Zhang S, Cai J, Xie W, Luo H, Yang F Abstract MicroRNA (miR)-202 has been reported to be involved in the regulation of human cancer progression including bladder cancer, non-small cell lung cancer, pancreatic cancer and esophageal squamous cell carcinoma. However, the function of miR-202 in prostate cancer remains largely unknown. The present study demonstrated that miR-202 was downregulated in human prostate cancer tissues and cell lines. And overexpression of miR-202 significantly inhibited the proliferation, migration and invasion of prostate cancer cells, but induced cell apoptosis. Moreover, miR-202 s...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Chen X, Cai S, Li B, Zhang X, Li W, Linag H, Cao X Abstract The aim of the present study was to identify the differentially expressed genes (DEGs) in esophageal squamous-cellcarcinoma (ESCC) and provide potential therapeutic targets. The microarray dataset GSE20347 was downloaded from the Gene Expression Omnibus (GEO) database, and included 17 tissue samples and 13 normal adjacent tissue samples from patients with ESCC. A total of 22,277 DEGs were identified. A heat map for the DEGs was constructed with the Morpheus online tool and the top 200 genes (100 upregulated and 100 downregulated) were selected for...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
In this study we evaluate the 8th edition of American Joint Committee on Cancer (AJCC) staging criteria and lymph node ratio (LNR) to identify patients affected by squamous cell carcinoma of the tongue (SCCT) with worse prognosis.Study Design. 73 patients with SCCT were analyzed retrospectively. Tumors staging was revised according to 7th and 8th editions of AJCC. Depth of invasion (DOI), extranodal extension (ENE), and LNR were evaluated.Results. 25 patients were reclassified: 17 received an upstage in staging score, 8 changed pT or pN remaining in the same stage group. In pT upstaged group, 7 patients experienced recurre...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Voriconazole exposure and longer duration of voriconazole were found to be significantly associated with increased risk of squamous cell carcinoma. Regular dermatologic surveillance should be considered for the patients taking voriconazole, especially those at high risk of developing squamous cell carcinoma.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
Condition:   Squamous Cell Carcinoma of the Head and Neck Interventions:   Drug: Durvalumab;   Radiation: Stereotactic Body Radiation Therapy (SBRT);   Procedure: Standard of Care Therapy Sponsors:   University of Colorado, Denver;   AstraZeneca Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Amôr NG, de Oliveira CE, Gasparoto TH, Vilas Boas VG, Perri G, Kaneno R, Lara VS, Garlet GP, da Silva JS, Martins GA, Hogaboam C, Cavassani KA, Campanelli AP Abstract Squamous cell carcinoma (SCC) is the second most common form of skin cancer and the mechanism(s) involved in the progression of this tumor are unknown. Increases in the expression of IL-33/ST2 axis components have been demonstrated to contribute to neoplastic transformation in several tumor models and interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue. Based on these observations, we ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusion: The infiltration of thyroid cartilage occurred in 8.3% of tumors and did not change the outcome in patients submitted to frontolateral laryngectomy. The morphological characteristics did not present any statistical significance.ORL
Source: ORL - Category: ENT & OMF Source Type: research
Contributors : Himiko Kodaira ; Hiroshi YokozakiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTumor-associated macrophages (TAMs) have important roles in the progression, angiogenesis and motility of various cancers. To study the effects of TAMs on the tumor microenvironment of ESCCs, we constructed an in vitro system for the differentiation of peripheral blood monocyte (PBMo)-derived macrophages into TAM-like PBMo-derived macrophages.We established a co-culture assay using a human ESCC cell line and TAM-like PBMo-derived macrophages and we performed a cDNA microarray analysis between monocultured and c...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
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