The Air Out There: Treatment Planning When Target Volumes Extend Beyond the Skin

A patient presented with squamous cell carcinoma of the vulva, pT2pN2c, stage IIIC status post radical vulvectomy and bilateral groin dissection. The pathology report revealed close and positive margins and lymphovascular space invasion at the primary site, as well as multiple positive lymph nodes with extracapsular extension. The patient was simulated head-first supine in the frog-legged position, with the assistance of a custom immobilization device. Simulation also included 5  mm of water-equivalent bolus applied to the right groin, corresponding to a region suspicious for positive nodes and extracapsular extension.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research

Related Links:

Publication date: Available online 20 October 2018Source: Urology Case ReportsAuthor(s): Y. Ayari
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: November 2018Source: Academic Radiology, Volume 25, Issue 11Author(s): Xiaoxia Li, Ying Yuan, Jiliang Ren, Yiqian Shi, Xiaofeng TaoRationale and ObjectivesWe aimed to investigate the incremental prognostic value of apparent diffusion coefficient (ADC) histogram analysis in patients with head and neck squamous cell carcinoma (HNSCC) and integrate it into a multivariate prognostic model.Materials and MethodsA retrospective review of magnetic resonance imaging findings was conducted in patients with pathologically confirmed HNSCC between June 2012 and December 2015. For each tumor, six histogram parameters w...
Source: Academic Radiology - Category: Radiology Source Type: research
We examined the programmed death-ligand 1 (PD-L1) expression in surgically resected pancreatic adenosquamous carcinoma (PASC) samples. Furthermore, the detection rate was also assessed using biopsy cases obtained from endoscopic ultrasound-guided fine needle aspiration (EUS-FNA).MethodsFifteen cases of PASC (six resected and nine EUS-FNA biopsied) from the Kurume University Hospital between 2009 and 2016 were used for the evaluation of PD-L1 expression. As a control group, 34 cases of pancreatic ductal adenocarcinomas (PDACs) were selected. To compare the positivity and intensity of PD-L1, two types of clones (SP263, E1L...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Authors: Yang H, Cao Y, Li ZM, Li YJ, Jiang WQ, Shi YX Abstract Cyclin-dependent kinase inhibitor 2A (p16INK4a) protein is a surrogate immunohistochemical marker of human papillomavirus infection in oropharynx squamous cell carcinoma (OPSCC). However, the effects of p16INK4a in non-OPSCC require additional analysis. In addition, major gaps remain in the literature, including small volumes of data for China. Therefore, the present study evaluated the frequency of p16INK4a positivity in patients with non-OPSCC in Southern China, and assessed its prognostic value. p16INK4a expression status in patients with non-OPSCC ...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Fujibayashi E, Yabuta N, Nishikawa Y, Uchihashi T, Miura D, Kurioka K, Tanaka S, Kogo M, Nojima H Abstract Three-dimensional (3D) cell culture systems have been used to obtain multicellular spheroidal cell aggregates, or spheroids, from cancer cells. However, it is difficult to efficiently prepare large tumor-derived spheroids from cancer cells. To circumvent this problem, we here used a tool equipped with removal membrane, called Spheroid Catch, for the selection and enrichment of large-sized and/or size-matched spheroids from human squamous cell carcinoma (SAS cells) without loss of recovery. After a fiv...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O Abstract The cystine-glutamate antiporter subunit xCT suppresses iron-dependent oxidative cell death (ferroptosis) and is therefore a promising target for cancer treatment. Given that cancer cells often show resistance to xCT inhibition resulting in glutathione (GSH) deficiency, however, we here performed a synthetic lethal screen of a drug library to identify agents that sensitize the GSH deficiency-resistant cancer cells to the xCT inhibitor sulfasalazine. This screen identified the oral anesthetic dyclon...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
In this study we showed a pivotal role of PKM2 acting as a non-metabolic function to promote cancer cell progression in human oral squamous cell carcinoma (OSCC) through the induction of epithelial-mesenchymal transition (EMT), which is crucial for the potential in cancer cell invasion, and post-translational TGIF2 degradation. PKM2 immunoreaction was strong in the cytoplasm of invasive cancer cells, and distinct in the nucleus of spindle-shaped cancer cells with EMT characteristics. TGIF2 nuclear immunoreaction was seen in dysplastic epithelial cells but was repressed in cancer cells. In vitro analyses, cytoplasmic expres...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
ConclusionHigher T stage and concurrent chemotherapy with radiotherapy showed significant association with chronic sinusitis. Concurrent chemotherapy also showed significant association with surgical treatment in head and neck cancer patients. Therefore, more careful surveillance and aggressive treatment of chronic sinusitis is needed in head and neck cancer patients who receive radiotherapy with concurrent chemotherapy or higher T stage.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
AbstractLocally advanced oral cancers extending to infratemporal fossa (ITF) are a challenge to head and neck surgeons. These tumors are classified as T4b whenever the masticator space (MS), pterygoid muscles (PM), and pterygoid plates (PP) are involved according to AJCC classification. Until recently, these tumors were considered inoperable and treated only with palliative intent. However, a few studies in the last decade showed that many of these tumors could be resected with a reasonably favorable prognosis by compartment resection of ITF, particularly when the tumor was below sigmoid notch of mandible. A few studies at...
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
The incidence of ocular metastasis from lung cancer is reported to be 0.1 –7%, with adenocarcinoma and small cell lung cancer accounting for the highest proportions of these cases. The majority of cases involve...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Case report Source Type: research
More News: Biology | Cancer & Oncology | Carcinoma | Pathology | Physics | Radiology | Skin | Skin Cancer | Squamous Cell Carcinoma