The Air Out There: Treatment Planning When Target Volumes Extend Beyond the Skin

A patient presented with squamous cell carcinoma of the vulva, pT2pN2c, stage IIIC status post radical vulvectomy and bilateral groin dissection. The pathology report revealed close and positive margins and lymphovascular space invasion at the primary site, as well as multiple positive lymph nodes with extracapsular extension. The patient was simulated head-first supine in the frog-legged position, with the assistance of a custom immobilization device. Simulation also included 5  mm of water-equivalent bolus applied to the right groin, corresponding to a region suspicious for positive nodes and extracapsular extension.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research

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Authors: Capodiferro S, Calabrese L, Maffini F, Cascardi E, Favia G, Maiorano E Abstract Oral squamous cell carcinoma in patients under 20 years of age is extremely rare, the alveolar gingiva being the most frequently affected site. The metachronous occurrence (eight years later) of a dentinogenic ghost cell tumour of the anterior maxilla in the same patient has never been previously reported. The patient had been diagnosed with a poorly differentiated squamous cell carcinoma of the ventral tongue when 12 years of age and was treated by en-block resection with functional neck dissection. Eight years later, he showe...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
We thank Drs Yang, Ma, and Li for their insightful comments1 on our review article regarding screening advances in esophageal squamous cell carcinoma.2 We agree that minimally invasive methods currently in development for the detection and surveillance of Barrett ’s esophagus (BE)3 can likely improve the yield of screening and evaluating for squamous cell carcinoma.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
We read with great interest the article by Codipilly et  al,1 which reviewed recent advances in screening for esophageal squamous cell carcinoma (ESCC) and its precursor, including endoscopic and nonendoscopic modalities. Mass endoscopic screening would present a cost-effective challenge and is not tenable in most high-incidence regions except in a few ultra–high-prevalence areas.2,3 Esophageal balloon cytology screening was once widely used in China but is no longer recommended because of its low accuracy in asymptomatic individuals.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
AbstractPurpose of ReviewTo review the role of frailty and comorbidities in determining operability and associated outcomes in patients with oral and oropharyngeal squamous cell carcinoma.Recent FindingsFrailty and comorbidity have been linked to multiple adverse outcome measures including risk of mortality, surgical complications, length of stay, intensity of care needs, discharge disposition, risk of readmission, and cost of healthcare delivery. There are diverse objective and validated measures of comorbidity and frailty. Addition of comorbidity and objective frailty measurements has been demonstrated to improve predict...
Source: Current Otorhinolaryngology Reports - Category: ENT & OMF Source Type: research
AbstractIn vivo detection of oral precancer has been carried out by a fluorescence-based, in-house-developed handheld probe on three groups: oral squamous cell carcinoma (OSCC), dysplastic (precancer), and control (normal). Measurements have been performed on a total of 141 patients and volunteers of different age groups. Excitation wavelength of 405  nm was used and fluorescence emission spectra were recorded in the scan range of 450.14 to 763.41 nm at very low incident power (122 μW) from different oral sites buccal mucosa (BM), lateral boarder of tongue (LBT), and dorsal surface of tongue (DST). Spectr...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
Conditions:   Head Cancer;   Facial Cancer;   Neck Cancer;   Upper AerodigestiveTract Cancer;   Oral Cancer Interventions:   Drug: Birinapant;   Radiation: Intensity modulated re-irradiation therapy (IMMRT) Sponsor:   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, the expression levels of distinct miRNAs extracted from formalin-fixed, paraffin-embedded (FFPE) samples of oral squamous cell carcinoma were compared.ResultsStatistical analysis revealed significant correlations between distinct miRNAs and disease recurrence (miR-99*, miR-194*; p
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Authors: Chen ZQ, Huang LS, Zhu B Abstract Background: The correlation between tumor markers (TM) and TNM stage of non-small-cell lung cancer (NSCLC) has not been widely reported. Methods: TM levels (CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, and SCC-Ag) in 424 cases of lung adenocarcinoma (LAC), 166 cases of lung squamous cell carcinoma (LSCC), and 103 cases of benign chest disease (BCD) were analyzed before treatment. Results: By Kendall's tau-b correlation analysis, CEA, CA125, CA15-3, CA19-9, CA72-4, CYFRA21-1, and SCC-Ag were correlated with T stage of LAC (r = 0.235, p
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
These researchers from Rotterdam explain that despite the high and rising incidence rate of keratinocyte cancer (KC) and the importance of incorporating patient values into evidence-based care, few studies have focused on the perspectives of patients with KC. Their aim was to identify the needs and preferences of patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) regarding care. They carried out a qualitative study consisting of three focus groups with patients with BCC and three focus groups with patients with SCC.
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Editorial Source Type: research
A 25-year-old patient treated for relapsing remitting multiple sclerosis (RRMS) with natalizumab had a rapid progression of a low grade squamous intraepithelial lesion to a FIGO stage 1B1 squamous cell carcinoma of the uterine cervix within 2 years. She was treated with radical hysterectomy and pelvic lymphadenectomy and subsequently developed a vault recurrence within 2 years. The recurrence was treated with definitive synchronous chemo-radiotherapy and she has been disease free for 7 years. This case and existing evidence on increased risk of developing cervical dysplasia under natalizumab show that MS patients under imm...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
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