Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors

Publication date: Available online 11 July 2018Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Debangshu Samanta, Gregg L. SemenzaAbstractCancer cells are characterized by high metabolic demand. The substrates in demand include oxygen, glucose, glutamine and lipids. Oxygen serves as a key substrate in cellular metabolism and bioenergetics. Hypoxia or low oxygen abundance is a common feature of the tumor microenvironment that occurs due to an imbalance in supply and demand. The metabolic response to hypoxia in both cancer cells and stromal cells is orchestrated by hypoxia-inducible factors (HIFs). In this review we summarize our current understanding of how HIFs modulate the metabolism of hypoxic cancer cells and immune cells, and how altered metabolism plays a role in cancer progression.
Source: Biochimica et Biophysica Acta (BBA) Reviews on Cancer - Category: Cancer & Oncology Source Type: research